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  • 1
    Electronic Resource
    Electronic Resource
    Vitamin E concentration in breast adipose tissue of breast cancer patients (Kuopio, Finland) (1996)
    Springer
    Cancer causes & control 7 (1996), S. 591-595 
    Details
    ISSN: 1573-7225
    Keywords: α-tocopherol ; breast adipose tissue ; breast cancer ; Finland ; vitamin E
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Previous data on animals and humans suggest that vitamin E may be a protective factor against cancer. A low dietary vitamin E intake has been suggested to increase the risk of breast cancer. We examined the dietary intake and the concentration of vitamin E in breast adipose tissue of women in Kuopio, Finland, diagnosed between 1990 and 1992 with benign breast disease (n=34) and with breast cancer (n=32). In postmenopausal women, lower dietary intake (P=0.006) and a smaller concentration of vitamin E in breast adipose tissue (P=0.024) were observed in breast cancer patients than in subjects with benign breast disease. Partial correlation showed that the vitamin E concentration in the breast adipose tissue correlated positively with the dietary intake of vitamin E (r=0.25, P=0.023), indicating that the vitamin E concentration in breast adipose tissue reflects the dietary intake of vitamin E.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00051701
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  • 2
    Electronic Resource
    Electronic Resource
    Nuclear magnetic resonance spectroscopy of plasma to distinguish between malignant and benign diseases causing jaundice and cholestasis (1993)
    Springer
    Journal of cancer research and clinical oncology 119 (1993), S. 622-626 
    Details
    ISSN: 1432-1335
    Keywords: Cancer ; Jaundice ; Magnetic resonance spectroscopy ; NMR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The sera of 51 patients with malignant (n=25) and benign (n=26) hepatopancreatobiliary disorders were analysed by1H magnetic resonance spectroscopy (NMR) in order to distinguish between malignant and benign diseases causing jaundice and/or cholestasis. Macromolecular linewidths were determined both manually and automatically with a computed analysis, and both methylene (CH2) and methyl (CH3) resonances were evaluated. The mean linewidth of the CH3 peak was significantly narrower in the patients with malignant disease than in the patients with benign disease both in the manual and computed analyses, but no significant differences in the CH2 peak were detected. Diagnostic sensitivity and specificity of the CH3 peak determined in the computed analysis were 92% and 27% respectively. In the light of the current study, it seems obvious that because overlap between benign and malignant groups was too great,1H NMR spectroscopy of plasma is not of practical value in distinguishing between benign and malignant causes of jaundice and/or cholestasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01372726
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  • 3
    Electronic Resource
    Electronic Resource
    Tumour-associated trypsin inhibitor in the diagnosis of pancreatic carcinoma (1994)
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. 494-497 
    Details
    ISSN: 1432-1335
    Keywords: Diagnosis ; Pancreatic cancer ; Tumour markers ; TATI ; TPA ; TPS ; CEA ; CA 50 ; CA 242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The serum values of tumour-associated trypsin inhibitor (TATI) were measured in a prospective series of 97 patients with jaundice, 36 patients with unjaundiced cholestasis and 21 patients with suspicion of chronic pancreatitis or a pancreatic tumour, to assess its value in diagnosing pancreatic cancer. There were altogether 15 patients with cancer of the pancreas and 2 patients with cancer of the papilla of Vater. The highest serum TATI values were noticed in patients with choledocholithiasis, and raised values were also seen in patients with malignant disease of the liver or bile ducts. In the patients with pancreatic cancer, chronic pancreatitis or benign liver disease, the serum TATI values showed lower levels. The sensitivity of TATI in diagnosing pancreatic cancer was 41.1% with a specificity of 63.5% and an efficiency of 61.0%. In comparison to carcinoembryonic antigen (CEA), carbohydrate antigens CA 50, CA 242, tissue polypeptide antigen and tissue polypeptide-specific antigen, TATI showed a lower diagnostic value. When TATI was analysed in combination with the other markers (two tests positive), the combination of CEA with TATI reached the highest specificity (95.6%), efficiency (89.6%) and positive likelihood ratio (9.3). The results suggest that the diagnostic value of TATI is inferior to that of the established markers, but because of its different nature, it may be of help when used in combination as a complementary serum tumour marker in the diagnosis of pancreatic cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01191804
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  • 4
    Electronic Resource
    Electronic Resource
    Clinical relevance of p53 index and expression of proliferating cell nuclear antigen and Ki-67 in gastric cancer (1998)
    Springer
    Journal of cancer research and clinical oncology 124 (1998), S. 497-502 
    Details
    ISSN: 1432-1335
    Keywords: Key words Gastric cancer ; Prognosis ; p53 ; PCNA ; Ki-67
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The prognostic value of the immunohistochemical expression of p53 protein, proliferating-cell nuclear antigen (PCNA) and Ki-67 antigen was evaluated in a series of 116 stage I–II gastric cancer patients. The staining for p53 protein (staining frequency and intensity) in malignant cells was expressed as a p53 index. Similarly, the staining frequency and intensity for PCNA and Ki-67 were evaluated. The p53 index was independent of the stage and differentiation grade, but significantly related to DNA ploidy, S-phase fraction and mitotic activity. A high p53 index was a sign of inferior survival, compared to a low or intermediate index. p53-negative tumours were also associated with poor survival. In a multivariate analysis, only the depth of tumour infiltration and the presence of nodal metastases were independent prognostic factors in stage I–II gastric cancer. PCNA expression and Ki-67 antigen expression were not related to the stage, ploidy, proliferative activity or p53 expression, and they had no impact on survival. The results indicate that p53 protein expression may be of prognostic significance in gastric cancer, while PCNA and Ki-67 antigen expression have no predictive value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050205
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    Paper (German National Licenses)
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