Note: Front cover -- Half title -- Full title -- Copyright -- Dedication -- Contents -- Preface -- References -- Acknowledgements -- Introduction -- Reference -- 1 - The origins of mouse genetics and the discovery of the T -locus -- Introduction -- France -- United Kingdom -- Germany -- The United States -- The discovery of the T- locus -- Notes -- References -- 2 - The evolutionary modern synthesis, t -haplotypes in the wild, and reproductive isolation -- Genetics and natural selection-the search for mutants in the wild -- The Re-discovery of t alleles in wild mice -- Leslie Clarence Dunn, 1893-1974 -- Studies on prezygotic species isolation in Mus musculus and domesticus -- Update -- T/t complex effects on odorant discrimination -- Update on other odorant systems and subspecies isolation -- Haldane's rule, sex-chromosomal hybrid sterility genes -- Update on sex chromosomes and hybrid sterility -- The T/t complex and hybrid sterility -- Notes -- References -- 3 - Linkage studies, cytogenetics, and the discovery that t -haplotypes consist of a series of inversions-an over-the-Cen ... -- General linkage studies in mice -- The Haldane-Mitchison Scientific Clan -- John Scott Haldane, 1860-1936 -- John Burdon Sanderson Haldane, 1892-1964 -- Naomi Mitchison, nee Haldane, 1897-1999 -- Denis Mitchison, 1919- -- John Murdoch Mitchison, 1922-2011 -- Nicholas Avrion Mitchison, 1928- -- Timothy John Mitchison, 1961- -- General cytogenetic studies in mice -- t -allele linkage and cytogenetic studies -- Notes -- References -- 4 - Developmental genetics and recessive t -lethals -- Early studies of the developmental genetics of the T/t complex -- Other early developmental genetic models -- New tools for mouse developmental genetics -- Studies of T/t complex developmental genes, continued -- Pre-implantation lethals -- Post-implantation lethals. , T/T Homozygous lethality -- Notes -- References -- 5 - More population genetics with particular attention to the effects of t -allele mediated transmission ratio distortion -- Population genetics of t-alleles -- Notes -- References -- 6 - Mutation studies including those targeting the T/t -complex-a century long project -- Mutagenesis by ionizing radiation -- Chemical mutagenesis -- Insertional mutagenesis -- Mutagenic studies of the T/t complex -- Notes -- References -- 7 - Immunogenetics and the failed search for t -antigens-from mid-century and continuing to it's end -- Blood groups and the major histocompatability complex -- Tolerance -- A well-studied minor histocompatibility antigen: H-Y -- Association of the T/t -complex with histocompatibility antigens -- The failed search for t -complex antigens -- Ernst Caspari, 1909-1988 -- Notes -- References -- 8 - Gametogenesis and the genetics of gametes, including t -haplotype segregation distortion -- Oogenesis -- Spermatogenesis -- Spermatozoal RNA -- The genetics of spermatozoa -- X-inactivation during spermatogenesis and sex chromosome transmission ratio distortion -- Separation of X- and Y-bearing spermatozoa -- t- allele transmission ratio distortion -- Notes -- References -- 9 - The cloning era and the cloning of Brachury and other T/t complex genes -- Introduction -- The cloning of Brachury and other T/t complex genes -- Notes -- References -- 10 - X-inactivation, epigenetics, and imprinting, including of the T/t complex -- X-inactivation -- Mary F. Lyon, 1925-2014 -- Imprinting -- Maternal effects found at the T/t complex -- Mouse genetics and rare human diseases lead to the notion of gametic imprinting -- Epigenetics -- Chromosomal 17 imprinting and the T/t complex -- Notes -- References. , 11 - Sex determination, sex differentiation, and the Y chromosome-a mostly last quarter of the century effort -- Sex determination -- Anne McLaren (Anne Laura Dorinthea McLaren), 1927-2007 -- Sexual differentiation -- The mouse Y chromosome -- T/t complex-associated sex reversal and sex effects on elements of the complex -- Notes -- References -- 12 - Pharmacogenetics-a mostly last half of the century effort -- Introduction -- Xenobiotic detoxification -- CytochromeP450s -- N-acetyltransferase -- Glucuronosyl transferase -- Glutathione S-transferases -- Other enzymes involved in metabolic degradations -- Alcohol and aldehyde dehydrogenases -- Thiopurine methyltransferase -- Membrane transporters -- Receptor variation -- Note -- References -- Book Bibliography -- -- Index -- Back cover.