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  • 1
    Publication Date: 2020-12-11
    Description: Das Statuspapier fasst die Inhalte der Verbundprojekt-übergreifenden Diskussionen und Abstimmungen innerhalb des Querschnittsthemas (QST) „Analytik und Referenzmaterialien“ des Forschungsschwerpunkts zusammen. Die vorliegende Fassung wurde aus dem Diskussionspapier (Link Dokument Stand Oktober 2018) entwickelt. Dieser kontinuierliche Entwicklungs- oder Erarbeitungsprozess wurde durch eine Reihe von Veranstaltungen organisatorisch untermauert: • 1. Workshop (21. März 2018, Karlsruhe) • 2. Workshop (4. Juli 2018, Augsburg) • Statuskonferenz (9.-10. April 2019, Berlin) • 3. Workshop (27. November 2019, Berlin). Folgende Verbundprojekte haben sich aktiv bei den Veranstaltungen eingebracht: EmiStop, ENSURE, MicBin, MicroCatch_Balt, MikroPlaTaS, PLASTRAT, PLAWES, RAU, REPLAWA, RUSEKU, SubµTrack und TextileMission, sowie Vorläuferprojekte (MiWa, BASEMAN). Die einzelnen Textbeiträge im vorliegenden Statuspapier wurden durch ein Kommentierungsverfahren innerhalb des QST „Analytik und Referenzmaterialien“ abgestimmt. Motivation dieses Statuspapiers ist es, die im Forschungsschwerpunkt „Plastik in der Umwelt“ verwendeten physikochemischen Untersuchungsverfahren zur Analytik von Mikroplastik (MP) zusammenzuführen. Dadurch sollen möglichst validierte Methoden und vergleichbare Ergebnisse in den verschiedenen Projekten für die jeweils spezifische Fragestellung erreicht werden – insbesondere für zukünftige Projekte. Am Ende soll ein möglichst einheitlicher Methodenpool für die relevanten Fragestellungen in Wissenschaft, Wirtschaft und Verwaltung zur Verfügung stehen. Die vorliegenden Verfahrensempfehlungen beruhen auf dem aktuellen Wissensstand zur Analytik von MP und richtet sich an Akteure in der Wissenschaft als auch Anwender in der Praxis. BMBF Forschungsschwerpunkt „Plastik in der Umwelt“ November 2020 Statuspapier Mikroplastikanalytik 7 Es werden keine Verfahrensempfehlungen zu Untersuchungen von Wirkungen von MP auf Umweltmedien, Pflanzen oder Tiere gegeben (Siehe QST „Ökotoxikologie“). Es stellt nicht einzelne Ergebnisse oder Daten dar, die im Rahmen des Forschungsschwerpunktes entstanden sind.
    Language: German
    Type: info:eu-repo/semantics/report
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 62 (1996), S. 511-513 
    ISSN: 1432-0649
    Keywords: 32.80.Pj ; 07.65.Eh ; 07.75.h
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Deviations from the ideal quadrupole potential in a Paul ion trap create nonlinear resonances at certain operating points inside the stability diagram, where in the absence of potential pertubations storing times are very long. In the presence of those pertubations, however, the ions are lost from the trap. Since these resonances are mass dependent and the mass resolution is of the order of 100 it can be used to separate isotopes of a given element by choosing suitable trap operating conditions. Experiments on a natural mixture of Eu+ ions of mass 151 and 153 show that in a simple way, by proper choice of the operating point, the ions can be completely separated and laser-induced optical spectra of a single isotope can be received. This is the first time that mass separation in a Paul trap is performed by nonlinear effects in contrast to the usual way of using the mass dependent boundaries of the stability diagram
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-2568
    Keywords: H. PYLORI ; ULCER BLEEDING ; ACID SUPPRESSION
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bleeding peptic ulcer is the most importantcause of upper gastrointestinal bleeding. Our aim was tocompare the effect of anti-Helicobacter therapy withmaintenance treatment of H2-receptorantagonist in the prevention of relapses of ulcer andbleeding. Patients with bleeding duodenal or gastriculcers and H. pylori infection were randomized toreceive either a one-week course of triple therapy with bismuth subcitrate, metronidazole, andtetracycline plus ranitidine or a six-week course ofranitidine 300 mg/day. After the ulcers healed, theantibiotic-treated patients were not given anymedication, whereas the ranitidine-treated patientscontinued to receive a maintenance dose of 150 mg/day.One hundred twenty-six patients were randomized toreceive anti- Helicobacter therapy and 124 patients toreceive long-term ranitidine. H. pylori eradication wasachieved in 98.2% in those who received triple therapyand 6.1% in those who received ranitidine (P 〈0.0001). At the six-week follow-up, ulcer healing was documented in 88.2% in those who receivedtriple therapy and 86.1% in those who receivedranitidine (P = 0.639). Recurrent ulcer developed innine of the ranitidine-treated patients and three ofthem presented with recurrent upper gastrointestinal bleeding.One patient in the antibiotic group developed recurrentulcer without rebleeding (P = 0.01). It is concludedthat eradication of H. pylori is sufficient for the prevention of recurrent bleedingulcers.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of hepato-biliary-pancreatic surgery 4 (1997), S. 20-23 
    ISSN: 1436-0691
    Keywords: Endoscopic ; sphincterotomy ; pancreas ; biliary ; emergencies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the past two decades, the development of endoscopic sphincterotomy marked a major advancement in the treatment of pancreatobiliary disorders. Conditions which required traditional surgery in the past can now be effectively managed with therapeutic endoscopies. The application of endoscopy in emergencies was soon established worldwide. Critically ill patients who may not have withstood general anaesthesia can now be treated with much lower rates of morbidity and mortality. We review the role of endoscopic sphincterotomy in the treatment of various pancreatobiliary emergencies.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2013-10-03
    Description: BACKGROUND Estrogen receptor (ER) and peroxisome proliferator-activated receptor gamma (PPARγ) are associated with thyroid tumorigenesis and treatment. However, the interaction between them has not been studied. METHODS The impact of ER over-expression or down-expression by DNA/small interfering RNA (siRNA) transfection, ERα agonists, and the ERβ agonist diarylpropiolnitrile (DPN) on PPARγ expression/activity was examined in papillary thyroid carcinoma (PTC) and anaplastic thyroid carcinoma (ATC) cells. The effects of PPARγ modulation by rosiglitazone (RTZ), a PPARγ ligand, and of PPARγ siRNA on ER expression were determined. Cellular functions reflected by cell proliferation and migration were assayed. Apoptosis was analyzed by terminal deoxynucleotidyl transferase dUTP nick-end labeling, and apoptotic-related proteins were evaluated by Western blot analysis. RESULTS PPARγ protein and activity were reduced by the over-expression of either ERα or ERβ, whereas repression of ERα or ERβ increased PPARγ expression. The administration of RTZ counteracted the effects of ER and also reduced their expression, particularly in PTC cells. Moreover, knockdown of PPARγ increased ER expression and activity. Functionally, ERα activation offset the inhibitory effect of PPARγ on cellular functions, but ERβ activation aggregated it and induced apoptosis, particularly in PTC cells. Finally, the interaction between ERβ and PPARγ enhanced the expression of proapoptotic molecules, such as caspase-3 and apoptosis-inducing factor. CONCLUSIONS This study provides evidence supporting a cross-talk between ER and PPARγ. The reciprocal interaction between PPARγ and ERβ significantly inhibits the proliferation and migration of thyroid cancer cells, providing a new therapeutic strategy against thyroid cancer. Cancer 2013. © 2013 American Cancer Society.
    Print ISSN: 0008-543X
    Electronic ISSN: 1097-0142
    Topics: Biology , Medicine
    Published by Wiley-Blackwell on behalf of The American Cancer Society.
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  • 6
    Publication Date: 2016-07-21
    Description: To understand the impact of microplastic (MP) pollution to aquatic ecosystems, it is important to identify the mechanisms of interaction with organisms. Exposure experiments, like the study of Sussarellu et al. (1) recently published in PNAS, may provide such insights. However, the results of dose–response experiments must always be interpreted...
    Keywords: Letters
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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