GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 315 (1994), S. 279-284 
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annals of surgical oncology 3 (1996), S. 393-399 
    ISSN: 1534-4681
    Keywords: Ureter ; Obstruction ; Cancer ; Stent ; Decompression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The purpose of this study was to assess the morbidity and determine survival after ureteral decompression in patients with advanced nonurologic malignancies. Methods: Between June 1988 and June 1993 78 patients were referred to a single surgeon for ureteral decompression. Records were analyzed in relation to primary diagnosis, early and late complications, number of hospitalizations, and survival after decompression. Results: Seventy-two percent of patients initially underwent decompression endoscopically, and 28% required percutaneous nephrostomy placement at initial decompression. Complications occurred in 50% of patients and most commonly included infection (29%), stent obstruction and encrustation (28%), and gross hematuria (9%). The median survival for all patients after the first decompression procedure was 6.8 months (range 0.5–46.1), with an actuarial survival rate at 1 year of 55% and at 3 years of 30%. The eight patients with gastric/pancreatic cancer survived a median of just 1.4 months after decompression (range 0.77–11.8), with a 1-year actuarial survival rate of 12.5% and 3-year actuarial survival of 0%, which was significantly worse when compared with all other groups taken together or individually (p〈0.03). Conclusions: Ureteral decompression procedures in patients with advanced cancer can be an important component of palliative care but are associated with significant morbidity (50%) in patients whose median survival is 〈7 months. The role of ureteral decompression in patients with advanced gastric and pancreatic cancer is limited.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1432-0738
    Keywords: Key words NQO1 polymorphism ; Real-time PCR ; Colorectal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study used a rapid and single-step method for genotyping of NAD(P)H quinone oxidoreductase (NQO1) codon 609 polymorphism using real-time polymerase chain reaction (PCR)-analysis and subsequent melting curve analysis for the analysis of allelic distribution of NQO1. The design was a case control study of 323 Caucasians with colorectal cancer and 205 healthy controls. There was no difference in the frequencies of the mutated NQO1 allele (NQO1*2): 0.190 for control individuals and 0.195 for cancer patients, respectively (P=0.947). When this allelic distribution was further compared between non-smoking and smoking colorectal cancer patients, it appeared that the frequency of the wild-type allele NQO1*1 was higher in the smoking than in the non-smoking group [Odds ratio (OR), 0.434; 95% confidence interval (CI), 0.13–1.42]. This observation may suggest a protective role of the NQO1 wild-type allele in colon cancer susceptibility of individuals exposed to NQO1-inducing chemicals.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1432-0738
    Keywords: Key words CYP1B1 ; Light-Cycler
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to develop and validate a rapid assay for genotyping of CYP1B1 codon 432-polymorphism. The described method is a single tube assay and combines both rapid-cycle polymerase chain reaction (PCR) with real-time monitoring by amplification and generation of the melting profiles of an allele-specific fluorescent probe. With this method 300 samples were analysed from healthy, unrelated Germans. Genotype frequency determined for the mutated allele CYP1B1*2 was 0.40. The results show that genotyping of CYP1B1 codon 432-polymorphism with a real-time fluorescence PCR method is a rapid and reliable assay for the analysis of large numbers of samples.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2012-11-17
    Description: Rhabdomyosarcoma is the most common soft tissue sarcoma in the pediatric population, accounting for 5-8% of all childhood cancers. 1 There are two major histological subtypes: alveolar (ARMS) and embryonal (ERMS). The ARMS is genetically characterized by the reciprocal translocation t(2;13)(q35;q14) and its variant t(1;13)(p36;q14) resulting in PAX3/FOXO1 and PAX7/FOXO1 fusion genes, respectively. The embryonal subtype has a relatively better prognosis and different genetic features, generally gain of whole chromosomes 2, 7, 8, 11, 12, 13, and 20, 2,3 not associated with any consistent structural anomaly. Although ERMS is the most frequent subtype, accounting for 68% of RMS, 4 its genetic characterization remains incomplete and the clinicopathologic implications are not well established. We report here the histopathological and genetic findings in six ERMS (primary tumors and its recurrences) derived from three patients. © 2012 Blackwell Publishing Ltd
    Print ISSN: 0309-0167
    Electronic ISSN: 1365-2559
    Topics: Medicine
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2015-12-02
    Description: Despite the availability of several observationally constrained datasets of daily precipitation based on rain-gauge measurements, remote-sensing and/or reanalyses, we demonstrate a large disparity in the quasi-global land mean of daily precipitation intensity. Surprisingly, the magnitude of this spread is similar to that found in CMIP5 models. A weakness of reanalyses and CMIP5 models is their tendency to over simulate wet days, consistent with previous studies. However, there is no clear agreement within and between rain-gauge and remotely sensed datasets either. This large discrepancy highlights a shortcoming in our ability to characterise not only modelled daily precipitation intensities but even observed precipitation intensities. This shortcoming is partially reconciled by an appreciation of the different spatial scales represented in gridded datasets of in situ precipitation intensities and intensities calculated from gridded precipitation. Unfortunately, the spread in intensities remains large enough to prevent us from satisfactorily determining how much it rains over land.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...