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  • 1
    Electronic Resource
    Electronic Resource
    Early Indicators of Male Reproductive Toxicity (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 8 (1988), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Longitudinal data were analyzed for seminal characteristics of rhesus monkeys and beagles. The monkeys were exposed to DBCP; the beagles were exposed to acute or chronic whole body gamma irradiation. The semen was analyzed for volume and sperm concentration. Sperm were measured for percent motility, swimming speed, and head dimensions. Abnormalities of the sperm tail were also noted. All treatments resulted in measurable effects on the semen parameters. Sperm production, as evaluated by seminal sperm concentration or total sperm numbers in the ejaculate, was as informative of testicular toxicity as any other parameter or combination of parameters. A consistent finding was that changes in sperm output occurred concomitantly with changes in sperm motility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1539-6924.1988.tb01150.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Hypothalamic-pituitary thyroid abnormalities in children after renal transplantation (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 621-624 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Thyroid function ; Endocrine function ; Renal disease ; Renal transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Patients with a successful renal transplant may have abnormalities in thyroid function. We evaluated serum thyroid hormone levels, serum thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH), and the circadian pattern of serum TSH in 18 children aged 6.6 – 19.4 years (median 12.6 years), 4.0 ± 2.9 years after renal transplantation. In 14 children, immunosuppressive therapy included methylprednisone [mean (± SD) 0.17 ± 0.05 mg/kg per day], while in 11 it included deflazacort (0.32 ± 0.1 mg/kg per day). Seven children were studied twice, under methylprednisone and again while on deflazacort therapy. Mean total and free thyroxine (T4) values were significantly below the mean control levels (total T4 108.5 ± 21.5 vs. 118.7 ± 22.1 nmol/l, P 〈0.05 and free T4 14.4 ± 4.0 vs. 18 ± 4.9 pmol/l, P 〈0.001). Morning basal TSH levels were within the normal range. The mean TSH increment after TRH was 4.4 ± 3.5 mU/l, significantly lower than that of controls (10.8 ± 4.26, P 〈0.001). Of 7 patients on methylprednisone, 4 had nocturnal TSH surges below the normal range (95% confidence limits 47% – 300%); this occurred in 3 of 8 patients on deflazacort therapy. The TSH response to TRH was correlated with deflazacort dose. Patients on methylprednisone and deflazacort therapy had similar thyroid alterations. Our findings support the hypothesis that after renal transplantation some children have hypothalamic-pituitary thyroid abnormalities in which glucocorticoids may play a significant role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050174
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  • 3
    Electronic Resource
    Electronic Resource
    The Hypolipidemic Effects of l-Acetyl-4-phenyl-l,2,4-triazolidine-3,5-dione in Rodents (1993)
    Springer
    Pharmaceutical research 10 (1993), S. 1206-1211 
    Details
    ISSN: 1573-904X
    Keywords: triazolidine-3,5-dione ; hyperlipidemic ; high-density lipoprotein C (HDL-C) ; atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract l-Acetyl-4-phenyl-l ,2,4-triazolidine,5-dione (APTD), a potent hypolipidemic agent, lowered both serum cholesterol and triglyceride levels in normo- and hyperlipidemic rats at 10 or 20 mg/kg/day. The agent effectively lowered VLDL-cholesterol (VLDL-C) and LDL-C content and raised HDL-C content in normal and hyperlipidemic rats treated from 4 to 8 weeks. Similar effects on the incorporation of cholesterol into the lipoprotein fractions were observed after drug treatment. Tissue lipids, e.g. cholesterol, were lowered, whereas fecal cholesterol levels were increased. APTD's primary targets were acyl CoA cholesterol acyl transferase (ACAT) for cholesterol ester synthesis and sn-glycerol-3-phosphate acyl transferase (GPAT) and phosphatidylate phosphohydrolase (PPH) for triglyceride synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018980621299
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    Paper (German National Licenses)
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