Note: Front Cover -- Small Peptides Chemistry, Biology and Clinical Studies -- Copyright Page -- Table of Contents -- Acknowledgements -- Introduction -- CHAPTER 1. ANGIOTENSIN II -- 1. INTRODUCTION -- 2. RECEPTOR SUBTYPES OF ANGIOTENSIN II -- 3. AGONIST ANALOGUES OF ANGIOTENSIN II -- 4. PEPTIDE ANTAGONISTS OF ANGIOTENSIN II -- 5. NON-PEPTIDE ANTAGONISTS OF ANGIOTENSIN II -- 6. NON-PEPTIDE ANTAGONISTS OF ANGIOTENSIN II ACTING AT THE AT2 RECEPTOR -- 7. SUMMARY -- 8. REFERENCES -- CHAPTER 2. BOMBESIN/GASTRIN-RELEASING PEPTIDE -- 1. INTRODUCTION -- 2. ANTAGONISTS OF BOMBESIN/GRP -- 3. CONFORMATIONALLY RESTRICTED ANALOGUES OF BOMBESIN -- 4. BOMBESIN/GRP ANTAGONISTS AND CANCER -- 5. SUMMARY -- 6. REFERENCES -- CHAPTER 3. BRADYKININ ANALOGUES -- 1. INTRODUCTION -- 2. RECEPTOR SUBTYPES OF BRADYKININ -- 3. AGONIST ANALOGUES OF BRADYKININ -- 4. ANTAGONISTS OF BRADYKININ -- 5. BIOLOGICAL PROFILE OF HOE 140 AND RELATED ANTAGONISTS -- 6. SIDE EFFECTS ASSOCIATED WITH BRADYKININ ANTAGONISTS -- 7. SUMMARY -- 8. REFERENCES -- CHAPTER 4. CHOLECYSTOKININ ANALOGUES -- 1. INTRODUCTION -- 2. DISTRIBUTION AND BIOLOGICAL FUNCTIONS OF CHOLECYSTOKININ -- 3. CHOLECYSTOKININ RECEPTOR SUBTYPES AND RECEPTOR-SELECTIVE LIGANDS -- 4. PEPTIDE ANTAGONISTS OF CHOLECYSTOKININ AND GASTRIN -- 5. NON-PEPTIDE ANTAGONISTS OF CCK AND GASTRIN -- 6. SUMMARY -- 7. REFERENCES -- CHAPTER 5. ENKEPHALIN ANALOGUES -- 1. INTRODUCTION -- 2. ENZYMIC INACTIVATION OF ENKEPHALINS -- 3. EARLY STRUCTURE ACTIVITY RELATIONSHIP STUDIES -- 4. AGONIST ANALOGUES DISPLAYING ANALGESIC ACTIVITY -- 5. ANALOGUES WITH IMPROVED SELECTIVITY FOR THE μ and δ RECEPTORS -- 6. ANTAGONISTS OF ENKEPHALINS -- 7. SUMMARY -- 8 REFERENCES -- CHAPTER 6. LUTEINISING HORMONE RELEASING HORMONE -- 1. INTRODUCTION -- 2. ENZYMIC DEGRADATION OF LHRH -- 3. SAR OF LHRH AGONISTS -- 4. SAR OF LHRH ANTAGONISTS. , 5. LHRH ANTAGONISTS AND HISTAMINE RELEASE -- 6. HEXAPEPTIDE DERIVATIVES AS LHRH ANTAGONISTS -- 7. KETACONAZOLE DERIVATIVES AS LHRH ANTAGONISTS -- 8. FORMULATIONS OF LHRH AND THE ANALOGUES -- 9. PHARMACOLOGICAL AND CLINICAL STUDIES WITH LHRH AGONISTS AND ANTAGONISTS -- 10. SUMMARY -- 11. REFERENCES -- CHAPTER 7. SOMATOSTATIN -- 1. INTRODUCTION -- 2. ENZYMIC DEGRADATION OF SOMATOSTATIN AND ANALOGUES -- 3. AGONIST ANALOGUES OF SOMATOSTATIN. SAR STUDIES -- 4. CLINICAL APPLICATIONS OF SOMATOSTATIN ANALOGUES -- 5. SUMMARY -- 6. REFERENCES -- CHAPTER 8. TACHYKININS SUBSTANCE P, NEUROKININ A AND NEUROKININ B -- 1. INTRODUCTION -- 2. RECEPTOR SUBTYPES OF TACHYKININS -- 3. SAR OF THE MAMMALIAN TACHYKININS -- 4. ANTAGONISTS OF SUBSTANCE P -- 5. ANTAGONISTS OF NEUROKININ A AND NEUROKININ B -- 6. NON-PEPTIDE ANTAGONISTS OF THE TACHYKININS -- 7. BIOLOGICAL STUDIES USING SP ANALOGUES -- 8. SUMMARY -- 9. REFERENCES -- CHAPTER 9. INHIBITORS OF ASPARTYL PROTEASES. 1. RENIN -- 1. INTRODUCTION -- 2. INHIBITORS OF RENIN -- 3. SUMMARY -- 4. REFERENCES -- CHAPTER 10. INHIBITORS OF ASPARTYL PROTEASES. 2. HIV PROTEASE -- 1. INTRODUCTION -- 2. NATURE OF THE ENZYME -- 3. CHEMICAL APPROACHES USED IN THE DESIGN OF INHIBITORS -- 4. NON-PEPTIDE INHIBITORS OF HIV PROTEASE -- 5. SUMMARY -- 6. REFERENCES -- CHAPTER 11. METALLOPEPTIDASE (ACE, ENKEPHALINASE AND ATRIOPEPTIDASE) INHIBITORS -- 1. INTRODUCTION -- 2. INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME -- 3. INHIBITORS OF THE ENKEPHALIN DEGRADING DIPEPTIDYL- CARBOXYPEPTIDASE (ENKEPHALINASE) -- 4. INHIBITORS OF ATRIAL NATRIURETIC FACTOR (ANF) DEGRADING ENZYME -- 5. SUMMARY -- 6. REFERENCES -- CHAPTER 12. FORMULATION OF PEPTIDES -- 1. INTRODUCTION -- 2. POLYMERIC CONTROLLED DRUG DELIVERY SYSTEMS (DEPOT FORMULATIONS) -- 3. IMPROVEMENTS IN THE ORAL DELIVERY OF PEPTIDES -- 4. INTRANASAL ADMINISTRATION OF PEPTIDES. , 5. TRANSDERMAL lONTOPHORETIC DRUG DELIVERY OF PEPTIDES -- 6. ADMINISTRATION OF PEPTIDES BY OCULAR, VAGINAL AND RECTAL ROUTES -- 7. REFERENCES -- SUBJECT INDEX.

Note: Intro -- Title -- Preface -- Contents -- CH-1 -- CH-2 -- CH-3 -- CH-4 -- CH-5 -- CH-6 -- CH-7 -- CH-8 -- CH-9 -- CH-10 -- CH-11 -- CH-12 -- CH-13 -- CH-14 -- CH-15 -- CH-16 -- CH-17 -- CH-18 -- CH-19 -- CH-20 -- CH- 21 -- CH-22 -- CH-23 -- CH-24 -- CH-25 -- CH-26 -- CH-27 -- CH-28 -- CH-29 -- CH-30 -- CH-31 -- CH-32 -- CH-33 -- CH-34 -- CH-35 -- CH-36 -- CH-37 -- CH-38 -- CH-39 -- CH-40 -- CH-41 -- CH-42 -- CH-43 -- CH-44 -- CH-45 -- CH-46 -- CH-47 -- CH-48 -- CH-49 -- CH-50 -- CH-51 -- CH-52 -- CH-53 -- CH-54 -- CH-55 -- CH-56 -- CH-57 -- CH-58 -- CH-59 -- CH-60 -- CH-61 -- CH-62 -- CH-63 -- CH-64 -- CH-65 -- CH-66 -- CH-67 -- CH-68 -- Appendices.