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  • 1
    Electronic Resource
    Electronic Resource
    Cup–plate Assay of Serum Fibrinolysin (1955)
    [s.l.] : Nature Publishing Group
    Nature 175 (1955), S. 728-729 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A 0 -5 per cent solution of fibrinogen in sodium barb-itone- hydrochloric acid buffer pH. 8-0 was prepared and kept in a water-bath at 43. A 4-0 per cent solution, of agar in buffer was prepared and cooled to 53. Equal quantities of these two solutions were mixed with gentle stirring and poured ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/175728b0
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  • 2
    Electronic Resource
    Electronic Resource
    Metalloproteinase production by rabbit articular cartilage: comparison of the effects of interleukin-1α in vitro and in vivo (1994)
    Springer
    Virchows Archiv 425 (1994), S. 413-424 
    Details
    ISSN: 1432-2307
    Keywords: Interleukin-1 ; Metalloproteinase Collagenase ; Cartilage ; Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the effects of interleukin-1 on intact articular cartilage in vitro, explants from young and adult rabbits were cultured with interleukin-1 and the distributions of the matrix metalloproteinases and tissue inhibitor of metalloproteinases (TIMP-1) were investigated by indirect immunofluorescence microscopy. One to 2-week-old cartilage chondrocytes synthesized collagenase in response to pure or crude interleukin-1 (monocyte conditioned medium), with subarticular cells most responsive. Collagenase synthesis was not stimulated in adult articular chondrocytes when explants were treated with either pure or crude interleukin-1. Stromelysin, gelatinase and TIMP-1 could not be demonstrated within any zone of the cartilage, indicating that their synthesis was not stimulated by either pure or crude interleukin-1. The addition of fibroblast growth factors, either alone or in combination with interleukin-1, did not modify these responses. These results contrast markedly with observations on cultured chondrocyte monolayers, where interleukin-1 treatment induces near co-ordinate expression of metalloproteinases. To assess the effects of interleukin-1 in vivo, it was injected into adult rabbit knee joint spaces and the articular cartilage subsequently analysed for evidence of altered metalloproteinase production by immunocytochemistry. No significant increase in metalloproteinase or TIMP-1 synthesis by chondrocytes was detected, although the cartilage matrix showed a marked loss of toluidine blue metachromasia. We conclude that metalloproteinases are not involved in the rapid loss of proteoglycan from cartilage matrix in these situations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00189580
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  • 3
    Electronic Resource
    Electronic Resource
    Synovial Proliferation induced by Polysaccharides (1960)
    [s.l.] : Nature Publishing Group
    Nature 186 (1960), S. 251-252 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Jones and Carter1,2 have shown that a proliferative synovitis can be induced in guinea pigs by the subcutaneous or intravenous injection of bacterial polysaccharide complexes. These findings raised the possibility of inducing a similar effect by the intra-articular injection of other ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/186251a0
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  • 4
    Electronic Resource
    Electronic Resource
    Novel treatment for joint inflammation (1978)
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 372-373 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Old English rabbits (body weight 1.5-2.0 kg) were used throughout the study. A bilateral inflammation of the knee joints was induced by the intra-articular injection of a complex formed from 7.5 mg poly-D-lysine (molecular weight 150,000) and 7.5 mg hyaluronic acid7 (both Miles). The initial ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/271372a0
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  • 5
    Electronic Resource
    Electronic Resource
    Extracellular localization of cathepsin D in ossifying cartilage (1973)
    Springer
    Calcified tissue international 12 (1973), S. 313-321 
    Details
    ISSN: 1432-0827
    Keywords: Cathepsin D ; Extracellular ; Ossification ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé De la cathepsine D extracellulaire d'origine principalement ostéoblastique a été démontrée par immunohistochimie dans le cartilage en voide de calcification de cultures d'os des membres d'embryons de poulet. L'intérêt de ce fait pour l'ossification est discuté.
    Abstract: Zusammenfassung Es wurde mit einer immunohistochemischen Methode gezeigt, daß extrazelluläres Kathepsin D, welches hauptsächlich aus Osteoblasten gewonnen wurde, Knorpel von kultivierten Knochen von Kükenembryonen mineralisiert. Die Bedeutung dieser Feststellung für den Mechanismus der Knochenbildung wird diskutiert.
    Notes: Abstract Extracellular cathepsin D derived mainly from osteoblasts has been demonstrated immunohistochemically in ossifying cartilage of cultured embryonic chick limb bones. The relevance of this observation to the mechanism of ossification is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013744
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  • 6
    Electronic Resource
    Electronic Resource
    Time Course of Action of Calcitonin on Resorbing Mouse Bones in vitro (1968)
    [s.l.] : Nature Publishing Group
    Nature 218 (1968), S. 1178-1179 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Our previous in vitro experiments6'7 showed that calcitonin prevents the formation of multinucleate osteo-clasts and their ability to mobilize bone mineral. To investigate further the mode of action of calcitonin we have developed a system for bone culture in which the hormone rapidly inhibits bone ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2181178a0
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  • 7
    Electronic Resource
    Electronic Resource
    Role of Lysosomes in Adrenal Necrosis caused by Dimethylbenzanthracene (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 303-304 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In order to ascertain whether there is any relationship between in vivo damage and release of lysosomal enzymes, particulate fractions of organelles from rat adrenals, kidneys and livers were prepared. In the case of the adrenal and kidney, the whole mitochondrial fraction, prepared by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/209303b0
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  • 8
    Electronic Resource
    Electronic Resource
    Specific Inhibition of Cartilage Breakdown (1969)
    [s.l.] : Nature Publishing Group
    Nature 222 (1969), S. 285-286 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A specific precipitating antiserum to chicken cathepsin D has recently been raised in rabbits (unpublished work of P. D. W.). The antiserum strongly inhibits the action of pure cathepsin D on haemoglobin, and on chondromuco-protein in the viscometer, during incubation in the range pH 4-7; it has no ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/222285b0
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  • 9
    Electronic Resource
    Electronic Resource
    Activation of Lysosomes by Oxygen: Oxygen-induced Resorption of Cartilage in Organ Culture (1965)
    [s.l.] : Nature Publishing Group
    Nature 205 (1965), S. 140-141 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] FOLLOWING the in vivo observations of Johnson on the distribution of tissue types in bone tumours and the correlation between this distribution and the blood supply1, it has been demonstrated that exposure of skeletal tissues in culture to elevated partial pressures of oxygen causes resorption and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/205140a0
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  • 10
    Electronic Resource
    Electronic Resource
    Fat-Soluble Vitamins and Biological Membranes (1964)
    [s.l.] : Nature Publishing Group
    Nature 204 (1964), S. 156-160 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] PAUL KARRER, who elucidated the chemical structure JL of vitamin A more than thirty years ago, remarked in 1960 (ref. 1): "We are fairly well informed about the physiological functions of the water-soluble vitamins because they are parts of enzymes, the reactions of which are pretty well known. On ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/204156a0
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