Note: Contract no. BM DO9KIE; 03-DO9KIE-5 , Differences between the printed and electronic version of the document are possible. - Immages not includes

Note: Intro -- Preface -- References -- The Fifth Weissenburg Symposium Biriciana -- Epigenetics-A Different Way of Looking at Genetics (September 15-17, 2014) -- Venue: Kulturzentrum Karmeliterkirche Weißenburg in Bayern -- Program -- Monday, 15 September -- Session I: Mechanisms -- Session II: Development -- Tuesday, 16 September -- Session III: Complex Diseases -- Session IV: Tumor Biology -- Wednesday, 17 September -- Session V: Immunology, Virology -- Session VI: Regulation -- Contents -- Chapter 1: Formation of Bacterial Lineages in Salmonella enterica by Epigenetic Mechanisms -- 1.1 Epigenetic Regulation Involving Heritable DNA Modification -- 1.1.1 O-Antigen Glycosylation (gtr) -- 1.1.2 O-Antigen Chain Length (opvAB) -- 1.1.3 Plasmid-Encoded Fimbriae (pef) -- 1.1.4 Std Fimbriae (std) -- 1.2 Epigenetic Regulation Sensu Lato -- 1.2.1 Virulence (SPI-1) -- 1.2.2 Biofilm Formation (csgD) -- 1.2.3 Intracellular Replication and Persistence -- 1.2.4 Adhesive Phenotype -- 1.2.5 Motility (fliC) -- 1.2.6 myo-Inositol Utilization -- 1.2.7 Type 1 Fimbriae (fim) -- 1.2.8 Long Polar Fimbriae (lpf) -- 1.2.9 Antibiotic Resistance -- 1.2.10 Bile Resistance -- 1.3 Concluding Remarks -- References -- Chapter 2: Noncoding RNAs and Chromatin Modifications in the Developmental Control of Imprinted Genes -- 2.1 Genomic Imprinting: An Epigenetic Phenomenon -- 2.2 Chromatin Features that Control Germ Line-Derived DNA Methylation -- 2.2.1 Acquisition of Imprinted DNA Methylation -- 2.2.2 Somatic Maintenance of the Methylated Alleles of ICRs -- 2.2.3 Somatic Maintenance of the Unmethylated Alleles of ICRs -- 2.3 Higher-Order Structuration of Chromatin at Imprinted Gene Loci -- 2.4 Long Noncoding RNAs that Mediate Imprinted Gene Silencing -- 2.4.1 LncRNA-Mediated Gene Repression in Cis -- 2.4.2 Histone Methylation Controls Placenta-Specific Imprinting. , 2.4.3 Imprinted LncRNAs with Effects in Trans on Other Imprinted Gene Loci -- 2.5 Long Noncoding RNAs Involved in Imprinted Gene Activation -- 2.6 Conclusions and Future Directions -- References -- Chapter 3: Lymphocyte Identity and Genomic Switches -- 3.1 How Is the Genome Being Used to Code and Regulate Genes? -- 3.2 How Are Enhancers Defined? -- 3.3 Locating Enhancers by Histone Marks -- 3.4 Locating Enhancers by Histone-Modifying Enzymes -- 3.5 T-Cell Enhancers and Their Diversity -- 3.6 Chromatin States -- 3.7 Chromatin Conformation -- 3.8 Defining Super-Enhancers -- 3.9 Super-Enhancers Associate with Cell Identity Genes -- 3.10 Super-Enhancer Regions Are Enriched for Trait-Linked SNPs -- 3.11 Transcription Factor Binding to Enhancers -- 3.12 Super-Enhancer Genes Show High Sensitivity to Perturbation -- 3.13 Conclusions -- References -- Chapter 4: Epigenetic Imprinting of Immunological Memory -- 4.1 Introduction -- 4.2 IFN-gamma and Th1 Memory -- 4.2.1 Lineage-Specifying Transcription Factors -- 4.2.2 Sequential Induction of Cytokine Signaling-Transcription Factor Pathways -- 4.2.3 Imprinting of IFNG/Ifng for Reexpression -- 4.3 IL-4 and Th2 Memory -- 4.3.1 Lineage-Specifying Transcription Factors -- 4.3.2 The First Intron of Il4 Controls IL-4 Memory -- 4.3.3 NFATc2 Regulates the Probability of IL-4 Reexpression in an All-or-None Fashion -- 4.4 IL-10 Is Excluded from Functional Cytokine Memory of Th Cells -- 4.4.1 The Observations -- 4.4.2 How Is IL-10 Expression Induced in Th Cells? -- 4.5 Concluding Remarks -- References -- Chapter 5: Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity -- 5.1 Introduction -- 5.2 Penetration of Short Peptides in the Cell Nucleus -- 5.3 The In Vitro Interaction of Peptides with Oligonucleotides and DNA -- 5.4 The In Vitro Interaction of Short Peptides with Histones. , 5.5 Short Peptides Affect Gene Expression and the Gene Epigenetic Status -- 5.5.1 Bronchogen -- 5.5.2 Pancragen -- 5.6 Conclusions -- References -- Chapter 6: Epigenetic Alterations of Viral and Cellular Genomes in EBV-Infected Cells -- 6.1 Epstein-Barr Virus Infection -- 6.2 EBV Epigenomics -- 6.3 Epigenetic Profiles of Cellular Genomes in EBV-Associated Neoplasms -- 6.4 The Role of EBV-Induced Histone Modifications and Polycomb Group Complexes in Oncogenesis -- 6.5 Three-Dimensional (3D) Regulation of Gene Transcription in EBV-Infected Cells: Modulation of Enhancer-Promoter Loop Format... -- References -- Chapter 7: Epigenetic Alterations upon the Insertion of Foreign DNA into Mammalian Genomes: Oncogenesis and Evolution -- 7.1 Background Information on Earlier Work -- 7.1.1 Foreign DNA in the Environment -- 7.1.2 Chromosomally Integrated Adenovirus DNA -- 7.1.3 Hypermethylation of Integrated Ad12 DNA -- 7.1.3.1 Cell Line TR12, a Revertant of the Ad12-Transformed Cell Line T637 -- 7.1.4 Promoter CpG Methylation and Promoter Silencing -- 7.1.5 Patterns of DNA Methylation in Different Parts of the Human Genome -- 7.2 Foreign DNA Integration into Mammalian Genomes Leads to Alterations in Methylation and Transcription Patterns -- 7.2.1 Alterations of DNA Methylation at the Site of Foreign DNA Insertion -- 7.2.2 Genome-Wide Increase in DNA Methylation in Ad12-Transformed Cells: Stability of Changes Even After the Loss of All Viral... -- 7.2.3 Alterations of Cellular DNA Methylation Patterns Are Also Elicited in Cells Transgenomic for Bacteriophage Lambda DNA or... -- 7.2.4 Alterations of Cellular Gene Activities in Hamster Cells Transgenomic for Ad12 or Bacteriophage Lambda DNA -- 7.2.5 Alterations of CpG Methylation Patterns Way Upstream of the FMR1 Boundary in Human Cells Immortalized by Epstein-Barr Vi. , 7.2.6 A Model System to Study the Epigenomic Destabilization in Human Cells Transgenomic for a 5.6kbp Bacterial Plasmid -- 7.3 Frequent Sources of Foreign DNA Invasion -- 7.3.1 Intestinal Tract -- 7.3.2 Vaginal Tract -- 7.4 Résumé and Outlook -- 7.4.1 Résumé -- 7.4.2 Outlook -- References -- Chapter 8: What Mechanisms Induce Methylation of FMR1 Gene Full Mutation? A Still Unanswered Question -- 8.1 Fragile X Syndrome and FMR1-Related Disorders -- 8.2 Clinical Findings -- 8.3 The FMR1 Gene -- 8.4 FMRP Protein Structure -- 8.5 FMRP Protein Function -- 8.6 Transcription of the FMR1 Locus -- 8.7 Epigenetic Modifications of the FMR1 Locus and the Enigma of Unmethylated Full Mutation Alleles -- 8.8 Animal Models -- 8.9 Therapeutic Strategies -- References -- Chapter 9: Silencing of Human Cytomegalovirus Gene Expression Mediated by Components of PML Nuclear Bodies -- 9.1 Human Cytomegalovirus: A Herpesvirus of Clinical Importance -- 9.2 Regulation of HCMV Gene Expression -- 9.3 PML Nuclear Bodies: General Features -- 9.4 PML-NB Proteins and HCMV Lytic Replication -- 9.5 Antagonistic Mechanisms of HCMV to Counteract PML-NB-Mediated Silencing -- 9.6 Enhanced HCMV IE Gene Expression in Primary Human Fibroblasts with a Stable Knockdown of PML, hDaxx, and Sp100 -- 9.7 HDaxx-Induced Changes of the Viral Chromatin Structure -- 9.8 PML-Induced Changes of the Viral Chromatin Structure -- 9.9 PML-NBs and HCMV Latency -- 9.10 Conclusions -- References -- Chapter 10: Azanucleoside DNA Methyltransferase Inhibitor Drugs: Update on Clinical Applications in Myelodysplastic Syndromes ... -- 10.1 5-Azacytidine -- 10.1.1 Clinical Studies of 5-Azacytidine Before the Discovery of Its Hypomethylating Activity -- 10.1.2 Clinical Studies of Low-Dose 5-Azacytidine in MDS -- 10.1.2.1 Development of 5-Azacytidine to First Approved MDS Therapy: CALGB Studies, AZA001 Trial. , 10.1.2.2 Combination Treatment of 5-Azacytidine with Histone Deacetylase Inhibitors and Other Drugs -- 10.2 5-Aza-2-Deoxycytidine (Decitabine) -- 10.2.1 Clinical Studies of Decitabine -- 10.2.1.1 Studies in Previously Untreated MDS and Chronic Myelomonocytic Leukemia -- 10.2.2 Clinical Studies of Decitabine in AML -- 10.2.2.1 Single-Agent and Combination Treatment Regimens in MDS and AML -- 10.3 Demethylating Agents in Older AML Patients -- 10.4 Comparison of 5-Aza and Decitabine -- 10.5 Conclusion and Future Perspectives -- References -- Chapter 11: Oxidative Stress and Cancer Epigenomics -- 11.1 Oxidative Stress and Carcinogenesis -- 11.2 Oxidative Stress and Epigenetic Modifications -- 11.3 Epigenetics and Cancer -- 11.4 Methods for the Detection of 5-mC, 5-OHmC, 5-fC, and 5-caC -- References -- Glossary of Terms.

Note: 273 Current Topics in Microbiology and Immunology -- Adenoviruses: Model and Vectors in Virus-Host Interactions -- Copyright -- Preface -- List of Contents -- List of Contributors -- 1 Immune System -- Evasion of the Immune System by Adenoviruses -- Immune Evasion by Adenovirus E3 Proteins: Exploitation of Intracellular Trafficking Pathways -- The Coxsackie-Adenovirus Receptor-A New Receptor in the Immunoglobulin Family Involved in Cell Adhesion -- Mechanisms of E3 Modulation of Immune and Inflammatory Responses -- 2 Oncogenesis -- Modulation of Oncogenic Transformation by the Human Adenovirus E1A C-Terminal Region -- Cell Transformation by Human Adenoviruses -- Tumorigenesis by Adenovirus Type 12 in Newborn Syrian Hamsters -- E1A-Based Determinants of Oncogenicity in Human Adenovirus Groups A and C -- 3 Gene Therapy -- Replicating Adenoviruses in Cancer Therapy -- Adenovirus Vectors: Biology, Design, and Production -- Subject Index.

Note: 272 Current Topics in Microbiology and Immunology -- Adenoviruses: Model and Vectors in Virus-Host Interactions -- Copyright -- Preface -- List of Contents -- List of Contributors -- 1 Virion and Structure -- Chapter 1 Molecular Evolution of Adenoviruses -- Chapter 2 Novel Partner Proteins of Adenovirus Penton -- Chapter 3 Structural Studies on Adenoviruses -- 2 Viral Replication -- Chapter 4 The Multifunctional Role of E1A in the Transcriptional Regulation of CREB/CBP-Dependent Target Genes -- Chapter 5 Adenovirus DNA Replication -- Chapter 6 Regulation of Adenovirus Packaging -- Chapter 7 Adenovirus DNA Replication: Protein Priming, Jumping Back and the Role of the DNA Binding Protein DBP -- Chapter 8 The Structure and Function of the Adenovirus Major Late Promoter -- 3 Host Cell Interactions -- Chapter 9 Remodelling of the Host Cell RNA Splicing Machinery During an Adenovirus Infection -- Chapter 10 Regulation of mRNA Production by the Adenoviral EIB 55-kDa and E4 Orf6 Proteins -- Chapter 11 Adenovirus Interaction with Its Cellular Receptor CAR -- Chapter 12 Transactivation of Human cdc2 Promoter by Adenovirus E1A -- Chapter 13 Nuclear Perturbations Following Adenovirus Infection -- Chapter 14 The Abortive Infection of Syrian Hamster Cells with Human Adenovirus Type 12 -- Subject Index.