Note: Front Cover -- The Alkaloids: Chemistry and Biology -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Clinical Studies of Camptothecin and Derivatives -- I. Introduction -- II. Mechanisms of Action -- III. Mutagenicity and Resistance Mechanisms -- IV. Irinotecan -- V. Topotecan -- VI. Considerations of Route of Administration -- VII. Investigational Derivatives -- VIII. Conclusions -- References. -- Chapter 2. Tremorgenic and Nontremorgenic 2,3-Fused Indole Diterpenoids -- I. Introduction -- II. Isolation -- III. Synthesis -- IV. Biosynthesis -- V. Structure and Tremorgenicity -- References -- Chapter 3. The Daphniphyllum Alkaloids -- I. Introduction -- II. Structures of Representative Alkaloids -- III. Biosynthesis and Biogenesis -- IV. Synthesis -- V. Conclusions -- References -- Chapter 4. The Manzamine Alkaloids -- I. Introduction -- II. Isolation and Structure Elucidation from Marine Sponges -- III. Biogenesis and Biosynthesis -- IV. Synthesis -- V. Pharmacology -- VI. Conclusions -- References -- Chapter 5. Sesquiterpene Pyridine Alkaloids -- I. Introduction -- II. Evoninate Sesquiterpene Pyridine Alkaloids and Derivatives -- III. Wilfordate Sesquiterpene Pyridine Alkaloids and Derivatives -- IV. Edulinate Sesquiterpene Pyridine Alkaloids -- V. Cassinate Sesquiterpene Pyridine Alkaloids -- VI. Lower Molecular Weight Sesquiterpene Pyridine Alkaloids. -- VII. Non-Celastraceous Sesquiterpene Pyridine Alkaloids -- VIII. Biosynthesis and Biogenesis -- IX. Biological Activity -- X. Taxonomic Considerations -- XI. Synthesis -- References -- Chapter 6. Chemical and Biological Aspects of Melanin -- I. Introduction -- II. Biogenesis of Melanin -- III. Natural Melanins -- IV. Investigations of Melanins by Physical Methods -- V. Synthetic Melanins -- VI. Physicochemical Properties and Biological Functions of Melanins -- References. , Index.

Note: Front Cover -- The Alkaloids: Chemistry and Pharmacology, Volume 44 -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. The Tropane Alkaloids -- I. Introduction -- II. Occurrence -- III. Synthesis -- IV. Reactions -- V. Biosynthesis -- VI. Spectroscopy -- VII. Pharmacology -- VIII. Perspectives -- References -- Chapter 2. The Biosynthesis of Tropane Alkaloids -- I. Introduction -- II. Organ Tissue Cultures for Biosynthetic Studies -- III. Formation of Putrescine -- IV. FormationofTropinone -- V. Formation of Tropine and Pseudotropine -- VI. Formation of Acidic Moieties of Tropeines -- VII. Formation of Tropeines -- VIII. Metabolism of Tropeines -- IX. Degradation and Oxidation of Tropeines -- X. Overall Regulation of Pathway -- XI. Future Prospects -- References -- Chapter 3. Simple Indolizidine Alkaloids -- I. Introduction -- II. Indolizidines with Alkyl and Functionalized Alkyl Appendages -- III. Elaeocarpus Alkaloids -- IV. Slaframine -- V. Hydroxylated lndolizidines -- VI. Summary -- References -- Chapter 4. Chemistry and Biology of Carbazole Alkaloids -- I. Introduction -- II. Occurrence -- III. Chemistry of Carbazole Alkaloids -- IV. Physical Properties of Carbazole Alkaloids -- V. Biogenesis of Carbazole Alkaloids -- VI. Biochemical and Medicinal Properties of Carbazole Alkaloids and Related Compounds -- References -- Cumulative Index of Titles -- Index.

Note: Front cover -- The Alkaloids: Chemistry and Biology -- Copyright page -- Contents -- Contributors -- Preface -- Chapter 1. The C18-Diterpenoid Alkaloids -- I. Introduction -- II. Classification, distribution, and occurrence -- III. NMR spectroscopy -- IV. Chemical reactions -- V. Pharmacological activity -- Acknowledgments -- References -- Chapter 2. Cyclopeptide Alkaloids from Higher Plants -- I. Introduction -- II. Classification -- III. Occurrence in Nature -- IV. New Cyclopeptide Alkaloids (2006-2008) -- V. Structure Elucidation and Stereochemistry -- VI. Synthesis -- VII. Biosynthesis -- VIII. Biological Activity -- IX. Conclusions -- Acknowledgments -- References -- Chapter 3. Alkaloids Toxic to Livestock -- I. Introduction -- II. Pyrrolidine Alkaloids -- III. Piperidine Alkaloids -- IV. Bipiperidine Alkaloids -- V. Pyridine Alkaloids -- VI. Polyhydroxy Indolizidine Alkaloids and Related Pyrrolizidine and Nortropane Alkaloids -- VII. Quinolizidine Alkaloids -- VIII. Tropane Alkaloids -- IX. Pyrrolizidine Alkaloids -- X. Isoquinoline Alkaloids -- XI. Diterpene (Larkspur) Alkaloids -- XII. Diterpene (Yew) Alkaloids -- XIII. Steroidal (Veratrum) Alkaloids -- XIV. Steroidal (Zigadenus) Alkaloids -- XV. Conclusions and Outlook -- References -- Chapter 4. Determination of Alkaloids through Infrared and Raman Spectroscopy -- I. Introduction -- II. General Overview of the IR Spectrum of Nitrogen Bridgehead Compounds: Bohlmann Bands -- III. Purine Alkaloids -- IV. Opioid Isoquinoline Alkaloids -- V. Natural Isoquinoline Alkaloid Dyes -- VI. Antimalarial Isoquinoline and Naphthyisoquinoline Alkaloids -- VII. Benzylisoquinoline Alkaloids -- VIII. Tropane Alkaloids -- IX. Pyrrolidine Alkaloids -- X. Piperidine Alkaloids -- XI. Quinolizidine Alkaloids -- XII. Monoterpenoid Indole Alkaloids -- XIII. Protoalkaloids -- XIV. Conclusions -- References. , Cumulative index of titles -- Subject Index.

Note: Front Cover -- The Alkaloids: Chemistry and Pharmacology, Volume 43 -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Allelochemical Properties or the Raison d'Être of Alkaloids -- I. Introduction -- II. Allelochemical Properties of Alkaloids -- III. Raison d'Être of Alkaloids -- IV. Conclusions -- References -- Chapter 2. Mammalian Alkaloids II -- I. Introduction -- II. Mammalian Indole Alkaloids -- III. Mammalian Isoquinoline Alkaloids -- IV. Mammalian Morphine -- V. Alkaloid Formation in Mammals as a Therapeutic Concept -- VI. Addendum -- VII. Conclusions -- References -- Chapter 3. Amphibian Alkaloids -- I. Introduction -- II. Steroidal Alkaloids -- III. Bicyclic Alkaloids -- IV. Tricyclic Alkaloids -- V. Monocyclic Alkaloids -- VI. Pyridine Alkaloids -- VII. Indole Alkaloids -- VIII. Imidazole Alkaloids -- IX. Morphine -- X. Guanidinium Alkaloids -- XI. Other Alkaloids -- XII. Summary -- Appendix -- References -- Cumulative Index of Titles -- Index.

Note: Cover -- The Alkaloids, Volume 52 -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Alkaloids from Sri Lankan Flora -- I. Introduction -- II. Surveys for Alkaloids -- III. Quinoline Alkaloids -- IV. Acridone Alkaloids -- V. Isoquinoline Alkaloids -- VI. Carbazole Alkaloids -- VII. Monoterpene Indole Alkaloids -- VIII. Steroidal Alkaloids -- IX. Phenanthroindolizidine Alkaloids -- X. Ancistrocladus Alkaloids -- XI. Colchicine and Related Alkaloids -- XII. Quinazoline and Quinazolone Alkaloids -- XIII. Miscellaneous Alkaloids -- XIV. Biological Activity -- XV. Summary and Conclusions -- References -- Chapter 2. The Sarpagine Group of Indole Alkaloids -- I. Introduction -- II. Occurrence -- III. Syntheses -- IV. Reactions -- V. Biosynthesis and Biogenesis -- VI. Spectroscopy -- VII. Pharmacology -- VIII. Perspectives -- References -- Chapter 3. Pharmacology of Ibogaine and Ibogaine-Related Alkaloids -- I. Introduction -- II. Historical Overview -- III. Chemical Structure and Properties -- IV. Pharmacokinetics -- V. General Pharmacological Actions -- VI. Lethality and Neurotoxic Effects -- VII. Effects on Specific Neurotransmitter Systems -- VIII. Conclusions -- References -- Chapter 4. Chemistry and Biology of Steroidal Alkaloids from Marine Organisms -- I. Introduction -- II. Monomeric Steroidal Alkaloids -- III. Dimeric Steroidal Alkaloids -- IV. Steroidal Amines from Marine Organisms -- V. Synthetic Studies -- VI. Biogenesis -- VII. Pharmacology -- VIII. Spectroscopy -- References -- Chapter 5. The Monoterpene Alkaloids -- I. Introduction -- II. Isolation and Structure Elucidation -- III. Synthesis and Semisynthesis -- IV. Physical and Spectral Properties -- V. Biosynthesis and Biogenesis -- VI. Pharmacology -- References -- Cumulative Index of Titles -- Index.

Note: Front Cover -- The Alkaloids: Chemistry and Biology, Volume 50 -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Fifty Years of Alkaloid Chemistry -- I. Introduction -- II. Childhood and Formative Years -- III. Higher Education and Early Employment -- IV. Scientific Career and Research -- V. Editorship -- VI. The Scientist and Society -- VII. Naturalist, Orchidist, Musician, and cuisiner -- VIII. Concluding Remarks -- Publications of R.H.F. Manske -- Chapter 2. Chemistry and Biology of Steroidal Alkaloids -- I. Introduction -- II. Isolation and Structure Elucidation -- III. Physical Properties -- IV. Biogenesis -- V. Some Synthetic Studies and Chemical Transformations -- VI. Pharmacology -- References -- Chapter 3. Biological Activity of Unnatural Alkaloid Enantiomers -- I. Introduction -- II. Analytical Criteria -- III. Unnatural Alkaloid Enantiomers -- IV. (+)-Morphine -- V. (+)-Physostigmine -- VI. (+)-Colchicine -- VII. (+)-Nicotine -- VIII. Conclusions -- References -- Chapter 4. The Nature and Origin of Amphibian Alkaloids -- I. Introduction -- II. Sarnandarines -- III. Batrachotoxins -- IV. The Purniliotoxin Class -- V. Histrionicotoxins -- VI. Gephyrotoxins -- VII. Decahydroquinolines -- VIII. Cyclopenta[b]quinolizidines -- IX. Epibatidine -- X. Pseudophrynamines -- XI. Pyrrolizidine Oximes -- XII. Coccinellines -- XIII. Bicyclic "Izidine" Alkaloids -- XIV. Monocyclic Alkaloids -- XV. Summary and Prospects -- References -- Chapter 5. Biochemistry of Ergot Alkaloids-Achievements and Challenges -- I. Introduction -- II. Historical Background -- III. The Natural Ergot Alkaloids -- IV. Producing Organisms -- V. Biosynthesis -- VI. Biotechnological Production -- VII. Pharmacological Properties of Ergolines -- VIII. Future Challenges -- References. , Chapter 6. Natural Polyamine Derivatives-New Aspects of Their Isolation, Structure Elucidation, and Synthesis -- I. Introduction -- II. Alkaloids with the Spermidine Skeleton -- III. Spermine Alkaloids -- IV. 3-Phenylpropenoyl Derivatives of Sperrnine and Spermidine -- V. Polyamines from Spiders, Wasps, and Marine Sponges -- References -- Chapter 7. Molecular Genetics of Plant Alkaloid Biosynthesis -- I. Introduction -- II. Monoterpenoid Indole Alkaloids -- III. Tetrahydrobcnzylisoquinoline Alkaloids -- IV. Bisbenzylisoquinoline Alkaloids -- V. Tropane and Nicotine Alkaloids -- VI. Acridone Alkaloids -- VII. Conclusions and Future Prospects -- References -- Chapter 8. Pseudodistomins: Structure, Synthesis, and Pharmacology -- I. Introduction -- II. Isolation and Structure -- III. Synthesis -- IV. Biogenesis -- V. Pharmacology -- References -- Chapter 9. Synthesis of the Aspidosperma Alkaloids -- I. Introduction -- II. The Aspidospermine Group -- III. Vindorosine and Vindoline -- IV. The Vincadifformine Group -- V. The Vindolinine Group -- VI. The Meloscine Group -- VII. The Aspidofractinine Group -- VIII. The Kopsine Group -- References -- Chapter 10. Synthetic Studies in Alkaloid Chemistry -- I. Introduction. -- II. Synthesis of Ipecacuanha Alkaloids -- III. Synthesis of Yohimbine Alkaloids -- IV. Synthesis of Corynantheidine Alkaloids -- V. Synthesis of Rauwolfia Alkaloids -- VI. Synthesis of Berbanes -- VII. Synthesis of Vincamine and Structurally Related Alkaloids -- VIII. Synthesis of Aspidosperma Alkaloids -- IX. Synthesis of Alkaloids from Catharanthus roseus -- X. Synthesis of Morphine -- XI. Synthesis of Epibatidine -- References -- Chapter 11. Monoterpenoid Indole Alkaloid Syntheses Utilizing Biomimetic Reactions -- I. Introduction. , II. Biomimetic Syntheses of Corynanthe-Releated Alkaloids from Secologanin, Strictosidine, and Their Analogs -- III. Biomimetic Syntheses of Aspidosperma and Iboga Alkaloids -- IV. Biomimetic Skeletal Rearrangements and Fragmentations -- V. Biomimetic Synthesis in the Sarpagine Family -- VI. Biomimetic Bisindole Alkaloid Syntheses -- VII. Conclusions -- References -- Chapter 12. Plant Biotechnology and the Production of Alkaloids: Prospects of Metabolic Engineering -- I. Introduction -- II. Plant Cell Cultures for the Production of Alkaloids -- III. Metabolic Engineering -- IV. Transcriptional Regulation and Signal Transduction Pathways -- V. Conclusions -- VI. Future Prospects -- References -- Chapter 13. History and Future Prospects of Camptothecin and Taxol -- I. Camptothecin -- II. Taxol -- References -- Chapter 14. Alkaloid Chemosystematics -- I. Introduction -- II. Alkaloids in Chemical Systematics: Laying Down the Rules -- III. The Evolution of Alkaloids -- IV. Handling Alkaloid Data in Systematic Studies -- V. Systematically Significant Distributions of Alkaloids in Higher Plant Taxa -- VI. Concluding Comments -- References -- Cumulative Index of Titles -- Index.

Note: Front Cover -- The Alkaloids: Chemistry and Pharmacology -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Gelsemium Alkaloids -- I. Introduction -- II. Sarpagine-Type Alkaloids -- III. Koumine-Type Alkaloids -- IV. Humantenine-Type Alkaloids -- V. Gelsedine-Type Alkaloids -- VI. Gelsemine-Type Alkaloids -- References -- Chapter 2. Alkaloids Containing Quinolinequinone and Quinolinequinoneimine Units -- I. Introduction -- II. Alkaloids Containing a Quinolinequinone Unit -- III. Alkaloids Containing a Quinolinequinoneimine Unit -- IV. Summary -- References -- Chapter 3. Biosynthesis of Terpenoid Indole Alkaloids in Catharanthus roseus Cells -- I. Introduction -- II. Biological Function of Alkaloids -- III. Pathway Leading to Terpenoid Indole Alkaloids: Intermediates and Enzymes -- IV. Genes Encoding Enzymes Involved in Terpenoid Indole Alkaloid Biosynthesis -- V. Metabolic Engineering -- VI. Regulation of Alkaloid Biosynthesis -- VII. Conclusions -- References -- Chapter 4. Macrocyclic Peptide Alkaloids from Plants -- I. Introduction -- II. Peptide Alkaloids from Higher Plants -- III. Cyclic Oligopeptides from Higher Plants -- References -- Cumulative Index of Titles -- Index.

Note: Cover -- The Alkaloids: Chemistry and Pharmacology -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Eburnamine-Vincamine Alkaloids -- I. Introduction -- II. Occurrence -- III. Syntheses -- IV. Reactions -- V. Biosynthesis -- VI. Spectroscopy -- VII. Pharmacology -- VIII. Perspectives -- IX. Addendum -- References -- Chapter 2. Antifungal Alkaloids -- I. Introduction -- II. Antifungal Alkaloids from Higher Plants -- III. Antifungal Alkaloids from Microorganisms -- IV. Antifungal Alkaloids from Marine Organisms -- V. Summary -- References -- Chapter 3. Chemistry of the Diterpenoid Alkaloids -- I. Introduction -- II. Norditerpenoid Alkaloids -- III. Diterpenoid Alkaloids -- IV. Skeletal Conversions of Diterpenoid Alkaloids -- References -- Chapter 4. Sulfur-Containing Alkaloids -- I. Introduction -- II. Alkaloids with One Sulfuer Atom in the Side Chain -- III. Alkaloids with One Sulfur Atom in the Ring -- IV. Alkaloids with More Than One Sulfur Atom -- V. Sulfur-Containing Alkaloids with a Peptide Structure -- VI. Pharmacology -- References -- Cumulative Index of Titles -- Index.

Note: Cover -- The Alkaloids: Chemistry and Pharmacology, Volume 45 -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Polyamine Toxins from Spiders and Wasps -- I. Introduction -- II. Structure and Nomenclature -- III. Syntheses of Polyamine Toxins and Related Analogs -- IV. Isolation and Purification of Spider and Wasp Toxins -- V. Characterization of Spider and Wasp Venoms -- VI. Final Remarks -- References -- Chapter 2. The Morphine Alkaloids -- I. Introduction -- II. Occurrence and Structure Elucidation -- III. Synthesis -- IV. Transformations -- V. Reactions -- VI. Opiate-Mediated Analgesia -- VII. Biogenesis -- References -- Chapter 3. Lycopodium Alkaloids -- I. Introduction -- II. Lycopodine Group -- III. Lycodine Group -- IV. Fawcettimine Group -- V. Miscellaneous -- VI . Biosynthesis and Biogenesis -- References -- Cumulative Index of Title -- Index.

Note: Front Cover -- The Alkaloids: Chemistry and Biology, Volume 53 -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Alkaloids as Chirality Transmitters in Asymmetric Catalysis -- I. Introduction -- II. Enantioselective Carbon-Hydrogen Bond Formation -- III. Asymmetric Oxidation -- IV. Enantioselective Carbon-Carbon Bond Formation -- V. Enantioselective Carbon-Heteroatom Bond Formation -- VI. Conclusion -- References -- Chapter 2. Biological Aspects of Aporphinoid Alkaloids -- I. Introduction -- II. Chemistry -- III. Pharmacology -- IV. Conclusion -- References -- Chapter 3. Alkaloids Containing an Isoquinolinequinone Unit -- I. Introduction -- II. Aza-anthraquinone Type Alkaloids -- III. Saframycin Type Alkaloids -- IV. Isoquinolinequinone Type Alkaloids -- V. Naphthyridinomycin Type Alkaloids -- VI. Summary -- References -- Chapter 4. Nitrogen-Containing Metabolites from Marine Bacteria -- I. Introduction -- II. Alkaloidal Chemistry of the Eubacteria -- Ill. Conclusions -- References -- Chapter 5. The Pharmacology and Therapeutic Aspects of Colchicine -- I. History of Colchicine -- II. Chemistry -- Ill. Pharmacokinetics -- IV. Mechanisms of Action -- V. Side Effects and Toxicity -- VI. Intoxication -- VII. Indications of Colchicine in Internal Medicine -- VIII. Colchicine Indications in Other Specialties -- IX. Conclusion -- Acknowledgment -- References -- Cumulative Index of Titles -- Index.