Keywords:
Phosphodiesterases.
;
Drugs--Analysis.
;
Phosphoric Diester Hydrolases--therapeutic use.
;
Drug Discovery.
;
Phosphodiesterase Inhibitors--pharmacology.
;
Phosphodiesterase Inhibitors--therapeutic use.
;
Phosphoric Diester Hydrolases--pharmacology.
;
Electronic books.
Description / Table of Contents:
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Along with its coverage of fresh and emerging ideas in this key field, the book examines all the major concepts related to the design and use of PDE inhibitors.
Type of Medium:
Online Resource
Pages:
1 online resource (531 pages)
Edition:
1st ed.
ISBN:
9783642179693
Series Statement:
Handbook of Experimental Pharmacology Series ; v.204
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=763214
DDC:
572.757
Language:
English
Note:
Intro -- Phosphodiesterases as Drug Targets -- Preface -- Contents -- Contributors -- Phosphodiesterase Inhibitors: History of Pharmacology -- Phosphodiesterase Inhibitors: Factors That Influence Potency, Selectivity, and Action -- Pharmacology, Clinical Efficacy, and Tolerability of Phosphodiesterase-4 Inhibitors: Impact of Human Pharmacokinetics -- Structural Insight into the Substrate Specificity of Phosphodiesterases -- A Fission Yeast-Based Platform for Phosphodiesterase Inhibitor HTSs and Analyses of Phosphodiesterase Activity -- The GAF-Tandem Domain of Phosphodiesterase 5 as a Potential Drug Target -- Small Molecule Allosteric Modulators of Phosphodiesterase 4 -- Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases -- Phosphodiesterases as Targets for Intermittent Claudication -- Phosphodiesterase Inhibition in Heart Failure -- Phosphodiesterases: Emerging Therapeutic Targets for Neonatal Pulmonary Hypertension -- Role of Phosphodiesterases in Adult-Onset Pulmonary Arterial Hypertension -- Treatment of Erectile Dysfunction and Lower Urinary Tract Symptoms by Phosphodiesterase Inhibitors -- Evaluation of the Therapeutic Utility of Phosphodiesterase 5A Inhibition in the mdx Mouse Model of Duchenne Muscular Dystrophy -- Phosphodiesterases as Targets for Modulating T-Cell Responses -- Cyclic Nucleotides and Phosphodiesterases in Monocytic Differentiation -- Phosphodiesterase Inhibitors in the Treatment of Inflammatory Diseases -- Harnessing the Clinical Efficacy of Phosphodiesterase 4 Inhibitors in Inflammatory Lung Diseases: Dual-Selective Phosphodiesterase Inhibitors and Novel Combination Therapies -- Phosphodiesterases in the Central Nervous System: Implications in Mood and Cognitive Disorders -- Therapeutic Potential of Phosphodiesterase Inhibitors in Parasitic Diseases -- Index.
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