Keywords:
RNA.
;
Electronic books.
Description / Table of Contents:
This book details the scope of RNA-based biology and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways. Featuring high quality illustrations, it presents a range of RNA-based mechanisms that connect in the RNA infrastructure.
Type of Medium:
Online Resource
Pages:
1 online resource (296 pages)
Edition:
1st ed.
ISBN:
9781461403326
Series Statement:
Advances in Experimental Medicine and Biology Series ; v.722
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=884053
DDC:
579.25
Language:
English
Note:
Intro -- Title Page -- Copyright Page -- Dedication Page -- PREFACE -- ABOUT THE EDITOR -- PARTICIPANTS -- Table of Contents -- ACKNOWLEDGEMENTS -- CHAPTER 1 THE RNA INFRASTRUCTURE: An Introduction to ncRNA Networks -- Abstract -- INTRODUCTION -- RNAs PROCESSING OTHER RNAs -- SPATIAL REGULATION OF EUKARYOTIC RNA PROCESSING -- RNA REGULATION, CONNECTING COMPONENTS OF THE RNA-INFRASTRUCTURE -- RNAi Networks -- RNA Networks and Epigenetics -- RNA Regulation in Prokaryotes -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 2 RNA INTERACTIONS -- Abstract -- INTRODUCTION -- ncRNA-DNA INTERACTIONS -- RNA-RNA INTERACTIONS -- General Properties -- MicroRNAs and RNA Interference -- Small Bacterial RNAs and Translational Control -- Small Nucleolar RNAs and Chemical Modifications -- RNAs in RNA End-Processing -- Guide RNAs and RNA Editing -- CRISPRs -- Ribozymes -- ncRNA-PROTEIN INTERACTIONS -- Ribonucleoparticles -- Long ncRNA as Coat-Hangers? -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 3 PLANT RNA SILENCING IN VIRAL DEFENCE -- Abstract -- INTRODUCTION -- GENERATION OF VIRAL SMALL INTERFERING RNAs: VIRUSES, vsiRNAs AND DICERS -- POST-DICING MODIFICATION OF vsiRNAs -- ANTIVIRAL EFFECTOR COMPLEXES -- AMPLIFICATION AND SPREAD OF ANTIVIRAL DEFENCE -- MOVEMENT OF ANTIVIRAL SILENCING -- VIRAL SUPPRESSORS OF RNA SILENCING -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 4 MicroRNAs AS POST-TRANSCRIPTIONAL MACHINES AND THEIR INTERPLAY WITH CELLULAR NETWORKS -- Abstract -- INTRODUCTION -- BIOGENESIS, GENOMIC ORGANIZATION AND EVOLUTION OF miRNAs -- METHODS TO IDENTIFY miRNAs AND THEIR TARGETS -- MicroRNA INTERPLAY WITH OTHER CELLULAR NETWORKS -- EXPRESSION DYNAMICS AND CROSSTALK OF miRNAs WITH OTHER REGULATORY FACTORS -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES.
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CHAPTER 5 SPATIOTEMPORAL ASPECTS OF MicroRNA-MEDIATED GENE REGULATION -- Abstract -- INTRODUCTION -- DNA DAMAGE RESPONSE AS AN EXAMPLE OF MULTILAYERED REGULATION -- MicroRNA-MEDIATED GENE SILENCING IN THE DDR -- MECHANISM OF FAST MicroRNA REGULATION -- LOCALIZATION OF THE MicroRNA-MEDIATED GENE SILENCING MACHINERY -- CONCLUSION -- REFERENCES -- CHAPTER 6 SPLICEOSOMAL RNA INFRASTRUCTURE: The Network of Splicing Components and Their Regulation by miRNAs -- Abstract -- INTRODUCTION -- THE SPLICEOSOME AS AN EXAMPLE OF THE RNA-INFRASTRUCTURE -- RNA-PROTEIN INTERACTION NETWORKS -- REGULATORY (EXPRESSION MODULATED) NETWORKS -- SPATIOTEMPORAL DYNAMIC RNA NETWORKS -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 7 CONSTRUCTION, STRUCTURE AND DYNAMICS OF POST-TRANSCRIPTIONAL REGULATORY NETWORK DIRECTED BY RNA-BINDING PROTEINS -- Abstract -- INTRODUCTION -- RNA BINDING PROTEINS AND POST-TRANSCRIPTIONAL REGULATION -- METHODS TO IDENTIFY RBPs AND THEIR TARGETS -- RBPs AND POST-TRANSCRIPTIONAL OPERONS -- POST-TRANSCRIPTIONAL NETWORK FORMED BY RBPs -- EXPRESSION DYNAMICS OF RBPs IN POST-TRANSCRIPTIONAL NETWORKS -- CONCLUSION -- ACKNOWLEDGEMENTS -- SUPPLEMENTARY MATERIAL -- REFERENCES -- CHAPTER 8 SAFE KEEPING THE MESSAGE: mRNP Complexes Tweaking after Transcription -- Abstract -- INTRODUCTION -- RNP-INFRASTRUCTURE -- POSTTRANSCRIPTIONAL MODULATOR OF GENE EXPRESSION -- PRE-mRNA PROCESSING AND THE INITIATION OF mRNP FORMATION -- MOBILIZATION TO THE SITE OF STORAGE AND mRNA LOCALIZATION -- CYTOSKELETON: ACTIN AND MICROTUBULE DYNAMICS AS A FLOATING RAFT FOR mRNPs SUBCELLULAR LOCALIZATION -- INTRA- AND INTERCELLULAR TRANSLOCATION OF mRNPs -- STORAGE OF mRNPs AND mRNA TURNOVER -- SYSTEMATIC TRANSLATION REPRESSION BY SMALL RNAs -- REINITIATING TRANSLATION OF THE LOCALIZED, TRANSLATIONALLY SEQUESTERED mRNAs -- CONCLUSION -- ACKNOWLEDGEMENT -- REFERENCES.
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CHAPTER 9 UNEXPECTED FUNCTIONS OF tRNA AND tRNA PROCESSING ENZYMES -- Abstract -- INTRODUCTION -- tRNAS AND TRANSCRIPTION -- tRNA FRAGMENTS -- Fragments Vary in Source, Size, Abundance and Composition -- Fragments and Development -- Stress-Induced Fragments in Fungi and Plants -- Fragments in Mammalian Cells -- Dicer Cleaves Mature tRNAs in Human Cells -- tRNase Z is Involved in Pre-tRNA Fragment Production -- Fragment Guided tRNase Z Cleaves mRNA -- Angiogenin Cleaves Mature tRNAs -- tRNA Halves Can Inhibit Translation -- AMINOACYL-tRNA FUNCTIONS BEYOND TRANSLATION -- tRNA PROCESSING ENZYMES AFFECT MORE THAN tRNA -- AMINOACYL-tRNA SYNTHETASES, tRNA AND DISEASE -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 10 PROGRAMMED DNA ELIMINATION IN TETRAHYMENA: A Small RNA-Mediated Genome Surveillance Mechanism -- Abstract -- INTRODUCTION -- NUCLEAR DIMORPHISM IN TETRAHYMENA -- EPIGENETIC REGULATION OF DNA ELIMINATION BY SMALL RNAS -- BIOGENESIS OF scnRNA -- scnRNA SELECTION -- scnRNA-INDUCED HETEROCHROMATIN FORMATION AND DNAE LIMINATION -- EVOLUTIONARY CONSIDERATIONS -- FUTURE PROSPECTS -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 11 LONG NONCODING RNA AND EPIGENOMICS -- Abstract -- INTRODUCTION -- LONG ncRNAs AND TUMOR SUPPRESSOR GENES -- LONG ncRNAs AND HOMEOBOX GENES -- LONG ncRNAs AND DOSAGE COMPENSATION -- LONG ncRNAs AND PLURIPOTENCY -- LONG ncRNAs AND GENOMIC IMPRINTING -- LONG ncRNAs AND CENTROMERIC HETEROCHROMATIN -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 12 PROMOTER-ASSOCIATED LONG NONCODING RNAs REPRESS TRANSCRIPTION THROUGH A RNA BINDING PROTEIN TLS -- Abstract -- INTRODUCTION -- THE TARGET RNA SEQUENCES RECOGNIZED BY TLS -- DOMAIN STRUCTURE OF TLS -- TRANSCRIPTION-REGULATORY LONG ncRNA, CYCLIN D1 pncRNA -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES.
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CHAPTER 13 RNA NETWORKS IN PROKARYOTES I: CRISPRs and Riboswitches -- Abstract -- INTRODUCTION -- RIBOSWITCHES CONTROL GENE AND OPERON EXPRESSION VIA METABOLITE BINDING -- THE CRISPR/Cas SYSTEM IS ANALOGOUS, BUT NOT HOMOLOGOUS, TO EUKARYOTIC RNAi -- CONCLUSION -- ACKNOWLEGEMENTS -- REFERENCES -- CHAPTER 14 RNA NETWORKS IN PROKARYOTES II: tRNA Processing and Small RNAs -- Abstract -- INTRODUCTION -- RNase P AND tRNA PROCESSING IN BACTERIA AND ARCHAEA -- BACTERIAL SMALL RNAs AND SIGMA FACTORS -- TRANSFER MESSENGER RNA -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 15 LOCALIZATION OF THE BACTERIAL RNA INFRASTRUCTURE -- Abstract -- INTRODUCTION -- LOCALIZED TRANSCRIPTION AND mRNA -- SPATIAL CONTROL OF RNA DEGRADATION AND PROCESSING -- EF-Tu IS A COMPONENT OF THE CYTOSKELETON -- LOCALIZATION OF TRANS-TRANSLATION COMPONENTS -- SPATIAL CONTROL OF GENE EXPRESSION -- CONCLUSION -- REFERENCES -- CHAPTER 16 SMALL RNA DISCOVERY AND CHARACTERISATION IN EUKARYOTES USING HIGH-THROUGHPUT APPROACHES -- Abstract -- INTRODUCTION -- THE MECHANISMS OF RNA SILENCING -- USING MICROARRAYS AND DNA SEQUENCING TO MEASURE RNA -- HIGH-THROUGHPUT APPROACHES FOR THE DISCOVERY AND FUNCTIONAL CLASSIFICATION OF sRNAs -- sRNA Discovery -- Target Identification -- Further sRNA Characterisation -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- CHAPTER 17 HOW OLD ARE RNA NETWORKS? -- Abstract -- INTRODUCTION -- REGULATORY NETWORKS OF SMALL RNAs -- RNA REGULATION AND DEFENCE AGAINST THE DARK ARTS -- OTHER REGULATORY RNAs -- HOW OLD ARE THE DIFFERENT INTERACTIONS OF RNA? -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- INDEX.
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