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  • 1
    Book
    Book
    Development of porphyroclast geometrics during non-coaxial flow : an experiment and analytical investigation = Ontwikkeling van porfieroklasten in niet-coaxiale vloeivelden (1996)
    Utrecht : Univ.
    Details Availability
    Keywords: Dissertation ; Report ; Hochschulschrift
    Type of Medium: Book
    Pages: VIII, 163 S , Ill., graph. Darst
    ISBN: 907157797X
    Series Statement: Geologica Ultraiectina 142
    DDC: 552/.4
    Language: English
    Note: Zugl.: Utrecht, Rijksuniv., Diss., 1996
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  • 2
    Electronic Resource
    Electronic Resource
    The Role of Homeotic Genes in Flower Development and Evolution (1991)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Plant Physiology and Plant Molecular Biology 42 (1991), S. 241-279 
    Details
    ISSN: 1040-2519
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pp.42.060191.001325
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of the responsiveness of isolated arteries and veins taken from the same dogs 17 days apart (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 590-591 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The present experiments demonstrate that isolated arteries and veins taken from the same dogs before and after an interval of 17 days show comparable responses to adrenergic nerve stimulation, exogenous norepinephrine and depolarizing solution. They provide an acceptable model for the in vitro study of chronic influences on canine vascular responsiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990067
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  • 4
    Electronic Resource
    Electronic Resource
    Early postnatal chlordiazepoxide administration: Permanent behavioural effects in the mature rat and possible involvement of the GABA-benzodiazepine system (1983)
    Springer
    Psychopharmacology 81 (1983), S. 261-266 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Postnatal treatment ; Long term behavioural and biochemical effects ; GABA-benzodiazepine receptors ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The long term behavioural and biochemical effects of chronic chlordiazepoxide treatment during the period of neuronal maturation in the rat have been investigated. The administration to lactating mothers of chlordiazepoxide at very low doses (0.22 and 2.6 mg/kg) in their drinking water affects both behavioural and biochemical parameters in offspring at 60 days of age and undrugged since weaning. A deficit in the acquisition of the conditioned avoidance response in treated rats was observed, although no significant difference in spontaneous locomotor activity between control and treated rats was found. 3H-Flunitrazepam binding sites in cerebral cortex and hippocampus were decreased by the treatment, whereas no change was detected in cerebellum. Moreover, 3H-muscimol binding sites increased in hippocampus with no changes in cerebral cortex and cerebellum. According to the different regional distribution of benzodiazepine type 1 and type 2 receptors, we suggest that type 2 receptors are selectively affected by the treatment, and that the GABA ergic receptor system is also permanently altered by administration of chlordiazepoxide during early postnatal life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427275
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  • 5
    Electronic Resource
    Electronic Resource
    Enduring behavioural and biochemical effects in the adult rat after prolonged postnatal administration of haloperidol (1981)
    Springer
    Psychopharmacology 74 (1981), S. 166-169 
    Details
    ISSN: 1432-2072
    Keywords: Postnatal treatment ; Haloperidol ; Apomorphine ; Stereotyped behaviour ; Locomotion ; Learning ; DOPAC ; HVA ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were administered 0.5 mg/kg SC of haloperidol (H) or saline (S) daily from day 1 after birth until 20 days of age. At 60 days of age (40 days after the postnatal treatment with H or S was interrupted) the stereotyped behaviour and the effects on locomotor activity elicited by apomorphine in S- and H-pretreated rats were investigated. The intensity of apomorphine (0.5–1 mg/kg, SC)-induced stereotyped behaviour was significantly greater in the H-pretreated group than in S-pretreated animals and this was accompanied by a much more marked reduction of locomotor activity in H-pretreated than in S-pretreated rats. Finally, at 80 days of age (60 days after the postnatal treatment with H or S was interrupted) rats were subjected to a Differential Reinforcement of Low Rates schedule (DRL 15-s). The results indicate that the acquisition of the DRL task performance criterion (Rs/Rf≤2.5) was significantly more rapid in S-pretreated rats than in H-pretreated ones. In parallel biochemical experiments, acute H produced smaller increases in dopamine turnover in chronic H-treated rats compared with S-treated controls. These data indicate that H treatment in neonatal rats induces behavioural and biochemical changes which can be observed up to 60 days after H withdrawal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432686
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  • 6
    Electronic Resource
    Electronic Resource
    Behavioural and biochemical effects in the adult rat after prolonged postnatal administration of clozapine (1983)
    Springer
    Psychopharmacology 81 (1983), S. 239-243 
    Details
    ISSN: 1432-2072
    Keywords: Postnatal treatment ; Clozapine ; Apomorphine ; Stereotyped behaviour ; Locomotion ; Learning ; HVA ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were administered 10 mg/kg SC of clozapine (C) or vehicle solution (S) daily from day 1 after birth until 20 days of age. At 60 days of age (40 days after the postnatal treatment with C or S was interrupted) the stereotyped behaviour and the effects on locomotor activity elicited by apomorphine in S-and C-pretreated rats were investigated. The intensity of stereotyped behaviour as well as the decrement in locomotion induced by apomorphine (0.5–1 mg/kg SC) were not influenced by chronic C administration during development. Finally, at 80 days of age (60 days after the postnatal treatment with C or S was interrupted) rats were subjected to a differential reinforcement of low rates schedule (DRL15s). The results indicate that the acquisition of the DRL task performance criterion (Rs/Rf≤2.5) was significantly more rapid in S-pretreated rats than in C-pretreated ones. In parallel biochemical experiments, homovanillic acid (HVA) content was measured in striatum in rats at 60 days of age (40 days after the postnatal treatment with C or S was interrupted). The results indicate that even if an acute challenge dose of 10 mg/kg C shows a certain degree of tolerance a single dose of 20 mg/kg C is still able to increase striatal HVA concentration in chronic C-pretreated animals. These data indicate that early postnatal administration of a non-cataleptogenic neuroleptic, like C, induces, in the adult rat, behavioural and biochemical changes which significantly differ from those elicited by a cataleptogenic neuroleptic, like haloperidol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427270
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  • 7
    Electronic Resource
    Electronic Resource
    DNA variation and evolution (reply) (1984)
    [s.l.] : Nature Publishing Group
    Nature 309 (1984), S. 286-286 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] COEN ET AL. REPLY—Genetic turnover by unequal exchange and its evolutionary consequence of molecular drive is well established in the rDNA multigene family of diverse species, since the classic studies of Don F. Brown and colleagues in 1972 (for recent reviews see refs 1–3). To measure ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/309286a0
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  • 8
    Electronic Resource
    Electronic Resource
    Presynaptic serotonin receptors regulate the release of 3H-serotonin in hypothalamic slices of the rabbit (1984)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 327 (1984), S. 102-106 
    Details
    ISSN: 1432-1912
    Keywords: 3H-5-hydroxytryptamine ; Rabbit hypothalamic slices ; Electrical stimulation ; High potassium stimulation ; Presynaptic serotonin receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hypothalamic slices of the rabbit brain were incubated with 10−7 M of 3H-serotonin (3H-5HT). After the incubation and an initial washout period, a nearly constant basal efflux of tritium was detected. This basal efflux was not significantly altered by Ca2+-free solution or by the 5HT-antagonist metitepin (10−5 M), but was augmented by chlorimipramine (10−5 M) and by unlabelled 5HT (10−6 M); the acceleration caused by unlabelled 5HT was absent in presence of chlorimipramine (10−5 M). Both electrical stimulation (4 Hz, 50 mA, 2 min) and high K+ (50 mM) induced an overflow of 3H. This overflow was nearly abolished in Ca2+-free solution. In presence of chlorimipramine (10−5 M) both the tritium overflow evoked by electrical stimulation and that evoked by high K+ were augmented by metitepin (10−5 M) and decreased in a concentration dependent manner by unlabelled serotonin (10−8–10−6 M); the latter effect was antagonized by metitepin (10−6 M and 10−5 M). These experiments suggest that in rabbit hypothalamic slices, the release of 3H-5HT is controlled by a negative feedback mechanism acting via presynaptic serotonin receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500902
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  • 9
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    An intracellular partitioning-based framework for tissue cell polarity in plants and animals [HYPOTHESIS] (2013)
    The Company of Biologists
    Details
    Publication Date: 2013-05-01
    Description: Katie Abley, Pierre Barbier De Reuille, David Strutt, Andrew Bangham, Przemyslaw Prusinkiewicz, Athanasius F. M. Maree, Veronica A. Grieneisen, and Enrico Coen Tissue cell polarity plays a major role in plant and animal development. We propose that a fundamental building block for tissue cell polarity is the process of intracellular partitioning, which can establish individual cell polarity in the absence of asymmetric cues. Coordination of polarities may then arise through cell-cell coupling, which can operate directly, through membrane-spanning complexes, or indirectly, through diffusible molecules. Polarity is anchored to tissues through organisers located at boundaries. We show how this intracellular partitioning-based framework can be applied to both plant and animal systems, allowing different processes to be placed in a common evolutionary and mechanistic context.
    Print ISSN: 0950-1991
    Electronic ISSN: 1477-9129
    Topics: Biology
    Published by The Company of Biologists
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  • 10
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    On genes and form [REVIEW] (2017)
    The Company of Biologists
    Details
    Publication Date: 2017-11-29
    Description: Enrico Coen, Richard Kennaway, and Christopher Whitewoods The mechanisms by which organisms acquire their sizes and shapes through growth was a major focus of D'Arcy Thompson's book On Growth and Form. By applying mathematical and physical principles to a range of biological forms, Thompson achieved fresh insights, such as the notion that diverse biological shapes could be related through simple deformations of a coordinate system. However, Thompson considered genetics to lie outside the scope of his work, even though genetics was a growing discipline at the time the book was published. Here, we review how recent advances in cell, developmental, evolutionary and computational biology allow Thompson's ideas to be integrated with genes and the processes they influence to provide a deeper understanding of growth and morphogenesis. We consider how genes interact with subcellular-, cellular- and tissue-level processes in plants to yield patterns of growth that underlie the developmental and evolutionary shape transformations Thompson so eloquently described.
    Keywords: Plant development
    Print ISSN: 0950-1991
    Electronic ISSN: 1477-9129
    Topics: Biology
    Published by The Company of Biologists
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