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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 12 (1982), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cortical thickness of the second metacarpal bone and lumbar spine fractures were determined radiographically in twenty-one Caucasian corticosteroid-dependent asthmatics (mean age, 61-2 years; range 47-73 years). The mean number of prednisone years per patient of continuous corticosteroid treatment averages 9.7 (range 5.0-21.5 years), and the mean accumulated dose of prednisone was 46.7 g (range 10.7-160 g). Thirteen of twenty-one (61.9%) patients had cortical thickness between 1 and 2 standard deviations (s.d.) below the age- and sex-specific mean for normals, but only four (19%) patients fell below 2 s.d. Although the study indicated decreased cortical thickness in the prednisone-treated group, in only one (4.8%) patient were vertebral fractures present, an incidence not unexpected in this age group. In serious chronic asthma, concern for bone structure should not prohibit the cautious use of appropriate corticosteroid regimens at the lowest possible maintenance dose.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The histological diagnosis of early lesions of mycosis fungoides (MF) is often difficult for dermatopathologists and prior studies have shown a low agreement rate among pathologists. An important reason for such difficulty may be the lack of specific histological criteria.Methods: We tested a new method to interpret and report biopsies suspicious for MF. The method is based on a grading system reflecting the pathologist’s degree of diagnostic certainty. A panel of four pathologists independently assessed a set of 50 biopsies suspicious for MF first without (Phase I) and subsequently with specific histological criteria (Phase II). A third Phase was carried out after a training session, using a new set of cases with corresponding immunophenotyping and gene rearrangement analysis. Weighted and unweighted kappa statistics were used to assess inter- and intra-pathologist variation.Results: The consensus rate among pathologists improved from 48% in Phase I to 76% in Phase III. Overall precision weighted kappas increased from 0.630 in Phase I to 0.854 in Phase III, indicating excellent inter-pathologist agreement by Phase III. There was a significant association between the presence of an abnormal phenotype and/or T-cell clonality and a higher diagnostic score.Conclusions: The use of uniform criteria and training sessions can substantially improve the consensus rate among pathologists in the diagnosis of MF.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1534-4681
    Keywords: Breast cancer ; Insurance ; Stage ; Treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Trends in the care of patients with cancer are monitored annually by the Commission on Cancer of the American College of Surgeons. In 1991 a patient care evaluation study of breast cancer was conducted, which among other questions examined the correlation of health insurance with type or quality of care delivered for breast cancer on a national basis. Methods: The tumor registry system of the American College of Surgeons was used to obtain data on patients with breast cancer diagnosed in 1983 and 1990. Trends in diagnosis and treatment were correlated with the type of insurance or lack of insurance. Results: Data were obtained from hospitals in 50 states on a total of 41,651 patients. The largest number of patients were covered by Medicare. Fewer than 5% were considered medically indigent. Medically indigent patients presented with higher stage disease and did not participate in a trend toward downstaging, which occurred between the two study years. The treatment of medically indigent patients appeared to be appropriate and comparable with better insured patients. Insurance type (health maintenance organization vs. private) did not affect stage, treatment, or outcome. Decisions to use controversial therapies, such as chemotherapy for stage I disease, did not appear to be financially driven. Conclusion: A nationwide pattern of care study for breast cancer indicates that medically indigent patients present with more advanced disease compared with better insured patients, but once the diagnosis is made, treatment and outcome have little to do with insurance type.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-3254
    Keywords: HIV/AIDS ; sexual behavior change ; maintenance ; lapse/relapse ; MSM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Understanding the antecedents of long-term patterns of sexual risk behavior is important for HIV/AIDS prevention research. This study assessed various psychosocial and demographic predictors of safer anal intercourse maintenance and of lapses to unsafe sex between 1984 and 1993 among 906 homosexually active men from the Chicago Coping & Change Study/MACS cohort. Semiannual self-reports of sexual activities were used to classify anal intercourse behavior patterns over a series of 2-year intervals. Two sorts of safer sex were evaluated: (1) definite safety, consistent condom use with all partners or abstinence and (2) modified safety, a broader standard that also included unprotected anal intercourse limited to a monogamous relationship. Results showed that the percentage of men who maintained definitely safe behavior increased from 16% of participants after the first 2 years of study to almost 63% during the 8th and 9th years (38% to 82% rates for modified safety). Lapses from definite safety peaked at 22% during the 3rd and 4th years, and 41% of the men lapsed from unfailing condom use at least once during the study (29% lapsed or relapsed by modified-safety criteria). Key predictors of long-term propensities (9-year rates)—both maintaining safer sex and lapse/relapse—included consistency of participation (a possible marker for behavior change intentions), predisposition toward risk taking, and age. Thus, personality traits that determine a person's level of commitment to behavior change, tendencies for risk taking, and age need to be considered when designing effective long-term HIV prevention interventions.
    Type of Medium: Electronic Resource
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