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  • 1
    Keywords: Chemistry, Organic-Periodicals. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (431 pages)
    Edition: 1st ed.
    ISBN: 9783709132654
    Series Statement: Fortschritte der Chemie Organischer Naturstoffe Progress in the Chemistry of Organic Natural Products Series ; v.36
    Language: English
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  • 2
    Keywords: Chemistry, Organic. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (261 pages)
    Edition: 1st ed.
    ISBN: 9783709163313
    Series Statement: Fortschritte der Chemie Organischer Naturstoffe Progress in the Chemistry of Organic Natural Products Series ; v.80
    Language: English
    Note: Intro -- 80 Fortschritte der Chemie organischer Naturstoffe -- Copyright -- Contents -- List of Contributors -- Naturally Occurring Isocyano/Isothiocyanato and Related Compounds * -- 1. Introduction -- 2. Monoterpenoid Indole Alkaloids from Blue-Green Algae -- 3. Marine Diterpenes from Sponges -- 4. Marine Sesquiterpenes from Sponges -- 5. Uncommon Marine Analogs -- 6. Other Terrestrial Compounds -- 7. Biogenesis and Biosynthesis -- 8. Discussion and Summary -- Addendum -- Acknowledgment -- References -- Sulfur-Containing Amides from Glycosmis Species (Rutaceae) -- 1. Introduction -- 2. Isolation and Structure Elucidation -- 3. Methylthiopropenoic Acid Amides -- 4. Methylsulfinylpropenoic Acid Amides -- 5. Methylsulfonylpropenoic Acid Amides -- 6. Methylthiocarbonic Acid Amides -- 7. Synthesis of Biogenic Sulfur-Containing Amides -- 8. Biological Activity -- 9. Biosynthesis -- 10. Chemotaxonomy -- Appendix: Sulfur-Containing Bisamides from Aglaia Species (Meliaceae) -- References -- Author Index -- Subject Index.
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 35 (1970), S. 3535-3538 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 38 (1966), S. 1247-1248 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1972), S. 863-872 
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The molecular ion of benzyl benzoate undergoes several decompositions, two of which are the loss of H2O and COOH·. To study these processes, the mass and IKE spectra of benzyl benzoate together with various deuterated benzyl benzoates and some of its isomers were studied. Evidence is presented to support the rearrangement processes of the molecular ion. A decomposition scheme is proposed to explain the observed transitions.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 6
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    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Publication Date: 2013-01-05
    Description: During hemodynamic stress, catecholamines and neurohumoral stimuli may induce co-activation of Gq-coupled receptors and β-adrenergic receptors (β-AR), leading to cardiac remodeling. Dynamic regulation of histone deacetylase 5 (HDAC5), a transcriptional repressor, is crucial during stress signaling due to its role in epigenetic control of fetal gene markers. Little is known about its regulation during acute and chronic β-AR stimulation and its cross-interaction with Gq signaling in adult cardiac myocytes. Here, we evaluate the potential cross-talk between Gq-driven and β-AR mediated signaling at the level of nucleocytoplasmic shuttling of HDAC5. We show the translocation of GFP-tagged wild type HDAC5 or mutants (S279A and S279D) in response to β-AR or Gq agonists. Isoproterenol (ISO) or PKA activation results in strong nuclear accumulation of HDAC5 in contrast to nuclear export driven by Ca2+-calmodulin protein kinase II and protein kinase D. Moreover, nuclear accumulation of HDAC5 under acute ISO/PKA signaling is dependent on phosphorylation of Ser-279 and can block subsequent Gq-mediated nuclear HDAC5 export. Intriguingly, the attenuation of Gq-induced export is abolished after chronic PKA activation, yet nuclear HDAC5 remains elevated. Last, the effect of chronic β-AR signaling on HDAC5 translocation was examined in adult myocytes from a rabbit model of heart failure, where ISO-induced nuclear import is ablated, but Gq-agonist mediated export is preserved. Acute β-AR/PKA activation protects against hypertrophic signaling by delaying Gq-mediated transcriptional activation. This serves as a key physiological control switch before allowing genetic reprogramming via HDAC5 nuclear export during more severe stress, such as heart failure.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
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  • 7
    Publication Date: 2013-10-22
    Description: Background and Purpose— Studies show that women are more likely to receive do-not-resuscitate (DNR) orders after acute medical illnesses than men. However, the sex differences in the use of DNR orders after acute intracerebral hemorrhage (ICH) have not been described. Methods— We conducted a retrospective study of consecutive patients hospitalized for acute ICH at a tertiary stroke center between 2006 and 2010. Unadjusted and multivariable logistic regression analyses were performed to test for associations between female sex and early (〈24 hours of presentation) DNR orders. Results— A total of 372 consecutive ICH patients without preexisting DNR orders were studied. Overall, 82 (22%) patients had early DNR orders after being hospitalized with ICH. In the fully adjusted model, early DNR orders were more likely in women (odds ratio, 3.18; 95% confidence interval, 1.51–6.70), higher age (odds ratio, 1.09 per year; 95% confidence interval, 1.05–1.12), larger ICH volume (odds ratio, 1.01 per cm 3 ; 95% confidence interval, 1.01–1.02), and lower initial GCS score (odds ratio, 0.76 per point; 95% confidence interval, 0.69–0.84). Early DNR orders were less likely when the patients were transferred from another hospital (odds ratio, 0.28, 95% confidence interval, 0.11–0.76). Conclusions— Women are more likely to receive early DNR orders after ICH than men. Further prospective studies are needed to determine factors contributing to the sex variation in the use of early DNR order after ICH.
    Keywords: Behavioral/psychosocial - stroke, Acute Cerebral Hemorrhage
    Print ISSN: 0039-2499
    Electronic ISSN: 1524-4628
    Topics: Medicine
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