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  • 1
    Online Resource
    Online Resource
    Berlin/Boston :Walter de Gruyter GmbH,
    Keywords: Biomathematics. ; Life sciences -- Mathematics. ; Electronic books.
    Description / Table of Contents: The De Gruyter Series in Mathematics and Life Sciences is devoted to the publication of monographs in the field. They cover topics and methods in fields of current interest that use mathematical approaches to understand and explain, model and influence phenomena in all areas of life sciences. This includes, among others, theory and application of biological mathematical modeling, complex systems biology, bioinformatics, computational biomodeling stochastic modeling, biostatistics, computational evolutionary biology, comparative genomics, or structural bioinformatics. Also, new types of mathematical problems that arise from biological knowledge shall be covered.
    Type of Medium: Online Resource
    Pages: 1 online resource (328 pages)
    Edition: 1st ed.
    ISBN: 9783110288537
    Series Statement: De Gruyter Series in Mathematics and Life Sciences Series ; v.1
    Language: English
    Note: Intro -- 1 Introduction -- 1.1 Scientific Frontiers at the Interface of Mathematics and Life Sciences -- 1.1.1 Developing the Language of Science and Its Interdisciplinary Character -- 1.1.2 Challenges at the Interface: Mathematics and Life Sciences -- 1.1.3 What This Book Is About -- 1.1.4 Concluding Remarks -- 2 Mathematical and Statistical Modeling of Biological Systems -- 2.1 Ensemble Modeling of Biological Systems -- 2.1.1 Introduction -- 2.1.2 Background -- 2.1.3 Ensemble Model -- 2.1.4 Computational Techniques -- 2.1.5 Application to Viral Infection Dynamics -- 2.1.6 Ensemble Models in Biology -- 2.1.7 Conclusions -- 3 Probabilistic Models for Nonlinear Processes and Biological Dynamics -- 3.1 Nonlinear Lévy and Nonlinear Feller Processes: an Analytic Introduction -- 3.1.1 Introduction -- 3.1.2 Dual Propagators -- 3.1.3 Perturbation Theory for Weak Propagators -- 3.1.4 T-Products -- 3.1.5 Nonlinear Propagators -- 3.1.6 Linearized Evolution Around a Path of a Nonlinear Semigroup -- 3.1.7 Sensitivity Analysis for Nonlinear Propagators -- 3.1.8 Back to Nonlinear Markov Semigroups -- 3.1.9 Concluding Remarks -- 4 New Results in Mathematical Epidemiology and Modeling Dynamics of Infectious Diseases -- 4.1 Formal Solutions of Epidemic Equation -- 4.1.1 Introduction -- 4.1.2 Epidemic Models -- 4.1.3 Formal Solutions -- 4.1.4 Separation of Variables -- 4.1.5 Solvability of General Equations -- 4.1.6 Concluding Remarks -- 5 Mathematical Analysis of PDE-based Models and Applications in Cell Biology -- 5.1 Asymptotic Analysis of the Dirichlet Spectral Problems in Thin Perforated Domains with Rapidly Varying Thickness and Different Limit Dimensions -- 5.1.1 Introduction -- 5.1.2 Description of a Thin Perforated Domain with Quickly Oscillating Thickness and Statement of the Problem -- 5.1.3 Equivalent Problem -- 5.1.4 The Homogenized Theorem. , 5.1.5 Asymptotic Expansions for the Eigenvalues and Eigenfunctions -- 5.1.6 Conclusions -- 6 Axiomatic Modeling in Life Sciences with Case Studies for Virus-immune System and Oncolytic Virus Dynamics -- 6.1 Axiomatic Modeling in Life Sciences -- 6.1.1 Introduction -- 6.1.2 Boosting Immunity by Anti-viral Drug Therapy: Timing, Efficacy and Success -- 6.1.3 Predictive Modeling of Oncolytic Virus Dynamics -- 6.1.4 Conclusions -- 7 Theory, Applications, and Control of Nonlinear PDEs in Life Sciences -- 7.1 On One Semilinear Parabolic Equation of Normal Type -- 7.1.1 Introduction -- 7.1.2 Semilinear Parabolic Equation of Normal Type -- 7.1.3 The Structure of NPE Dynamics -- 7.1.4 Stabilization of Solution for NPE by Start Control -- 7.1.5 Concluding Remarks -- 7.2 On some Classes of Nonlinear Equations with L1 -Data -- 7.2.1 Nonlinear Elliptic Second-order Equations with L1-data -- 7.2.2 Nonlinear Fourth-order Equations with Strengthened Coercivity and L1-Data -- 7.2.3 Concluding Remarks -- 8 Mathematical Models of Pattern Formation and Their Applications in Developmental Biology -- 8.1 Reaction-Diffusion Models of Pattern Formation in Developmental Biology -- 8.1.1 Introduction -- 8.1.2 Mechanisms of Developmental Pattern Formation -- 8.1.3 Motivating Application: Pattern Control in Hydra -- 8.1.4 Diffusive Morphogens and Turing Patterns -- 8.1.5 Receptor-based Models -- 8.1.6 Multistability -- 8.1.7 Discussion -- 9 Modeling the Dynamics of Genetic Mechanism, Pattern Formation, and the Genetics of "Geometry" -- 9.1 Modeling the Positioning of Trichomes on the Leaves of Plants -- 9.1.1 Introduction -- 9.1.2 Activator-inhibitor Reaction-diffusion Modeling of the Trichome Positioning -- 9.1.3 Hexagonal Recursion -- 9.1.4 Conclusions -- 10 Statistical Modeling in Life Sciences and Direct Measurements. , 10.1 Error Estimation for Direct Measurements in May-June 1986 of 131I Radioactivity in Thyroid Gland of Children and Adolescents and Their Registration in Risk Analysis -- 10.1.1 Introduction -- 10.1.2 Materials and Methods -- 10.1.3 Conclusion and Discussion -- 10.1.4 Appendix. Approximation of Conditional Expectations -- 11 Design and Development of Experiments for Life Science Applications -- 11.1 Physiological Effects of Static Magnetic Field Exposure in an in vivo Acute Visceral Pain Model in Mice -- 11.1.1 Introduction -- 11.1.2 Methods -- 11.1.3 Results -- 11.1.4 Discussion -- 11.1.5 Conclusions -- 12 Mathematical Biomedicine and Modeling Avascular Tumor Growth -- 12.1 Continuum Models of Avascular Tumor Growth -- 12.1.1 Introduction -- 12.1.2 Diffusion-limited Models of Avascular Tumor Growth -- 12.1.3 Tumor Invasion -- 12.1.4 Multiphase Models of Avascular Tumor Growth -- 12.1.5 Conclusions -- Index.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mathematical biology 39 (1999), S. 59-89 
    ISSN: 1432-1416
    Keywords: Key words: Tumour growth ; Stability analysis ; Weakly nonlinear analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract.  In this paper we study a mathematical model that describes the growth of an avascular solid tumour. Our analysis concentrates on the stability of steady, radially-symmetric model solutions with respect to perturbations taken from the class of spherical harmonics. Using weakly nonlinear analysis, previous results are extended to show how the amplitudes of the asymmetric modes interact. Attention focuses on a special case for which the model equations simplify. Analysis of the simplified model equations leads to the identification of a two-parameter family of asymmetric steady solutions, the dimensions of whose stable and unstable manifolds depend on the system parameters. The asymmetric steady solutions limit the basin of attraction of the radially-symmetric steady state when it is linearly stable. On the basis of these numerical and analytical results we postulate the existence of fully nonlinear steady solutions which are stable with respect to time-dependent perturbations.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1619-7089
    Keywords: Positron emission tomography ; Liver perfusion ; Modelling ; Oxygen-15 labelled water
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To date no satisfactory method has been available for the quantitative in vivo measurement of the complex hepatic blood flow. In this study two modelling approaches are proposed for the analysis of liver blood flow using positron emission tomography (PET). Five experiments were performed on three foxhounds. The anaesthetised dogs were each given an intravenous bolus injection of oxygen-15 labelled water, and their livers were then scanned using PET. Radioactivity in the blood from the aorta and portal vein was measured directly and simultaneously using closed external circuits. Time-activity curves were constructed from sequential PET data. Data analysis was performed by assuming that water behaves as a freely diffusible tracer and adapting the standard one-compartment blood flow model to describe the dual blood supply of the liver. Two particular modelling approaches were investigated: the dual-input model used both directly measured input functions (i.e. using the hepatic artery and the portal vein input, determined from the radioactivity detected in the aorta and portal vein respectively) whereas the single-input model used only the measured arterial curve and predicted the corresponding portal input function. Hepatic arterial flow, portal flow and blood volume were fitted from the PET data in several regions of the liver. The resulting estimates were then compared with reference blood flow measurements, obtained using a standard microsphere technique. The microspheres were injected in a separate experiment on the same dogs immediately prior to PET scanning. Whilst neither the single- nor the dual-input models accurately reproduced the arterial reference flow values, the flow values from the single-input model were closer to the microsphere flow values. The proposed single-input model would be a good approximation for liver blood flow measurements in man. The observed discrepancies between the PET and microsphere flow values may be due to the inherent temporal and spatial heterogeneity of liver blood flow. The results presented suggest that adaptation of the standard one-compartment blood flow model to describe the dual blood supply of the liver is limited and other flow tracers have to be considered for quantitative PET measurements in the liver.
    Type of Medium: Electronic Resource
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