Publication Date:
2014-02-25
Description:
Compensatory mutations offset fitness defects resulting from CD8 + T lymphocyte (CD8 TL )-mediated escape, but their impact on viral evolution following transmission to naive hosts remains unclear. Here, we investigated the reversion kinetics of Gag 181–189 CM9 CD8 TL escape-associated compensatory mutations in simian immunodeficiency virus (SIV)-infected macaques. Preexisting compensatory mutations did not result in acute-phase escape of the SIVmac239 CD8TL epitope Gag181-189CM9 and instead required a tertiary mutation for stabilization in the absence of Gag 181–189 CM9 escape mutations. Therefore, transmitted compensatory mutations do not necessarily predict rapid CD8 TL escape.
Print ISSN:
0022-538X
Electronic ISSN:
1098-5514
Topics:
Medicine
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