ISSN:
1468-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Background Hypopigmented (HMF) macular lesions are extremely rare manifestations of Mycosis fungoides (MF) with a predilection for blacks. Little is known of its prevalence, natural history and response to therapy in Asians.Objective The aim of the study was to investigate the natural history and clinicopathotogical aspects of HMF in an Asian population.Study Design A retrospective study of patient records from 1982 to 1989 was carried out and $100 immunostain was performed on sun exposed skin and covered skin of HMF patients and, as control, of healthy volunteers.Result 10 HMF patients (eight males and two females), of 18 (51.8%) who were seen for mycosis fungoides during this period, were studied. The majority were skin type III and IV, buttocks and limbs being important sites of predilection. Mean age at presentation and duration of disease prior to diagnosis were 20 and 4 years, respectively. Reduced melanin granules in basal keratinocytes and melanocytes, lymphocytic epidermotrophism and increased Langerhan's cell density were the most consistent microscopic findings. Response of patients to PUVA was excellent, with post treatment biopsy showing normal histology. Two patients with frequent relapse had extensive involvement and change in clinical pattern. On 5-year follow-up, HMF patients remained in stage 1. HMF variant is a common mode of presentation in young Asians, especially in males. It responds well to PUVA and has an excellent prognosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1468-3083.1994.tb00409.x
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