Keywords:
Chemistry, Metallurgic.
;
Nervous system -- Degeneration.
;
Electronic books.
Description / Table of Contents:
This book will appeal to both chemists and biologists at the post graduate and research level.
Type of Medium:
Online Resource
Pages:
1 online resource (295 pages)
Edition:
1st ed.
ISBN:
9781847555311
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=1185730
DDC:
546.3
Language:
English
Note:
Metallochemistry Of Neurodegeneration -- Contents -- Chapter 1 Introduction -- 1.1 General Model for Protein Misfolding, Aggregation, Amyloid Formation and Neurodegeneration -- 1.2 Specificity of Molecular Mechanisms in Major Neurodegenerative Diseases -- 1.2.1 Alzheimer Disease (AD) -- 1.2.2 Parkinson Disease -- 1.2.3 Amyotrophic Lateral Sclerosis -- 1.2.4 Prions Diseases -- 1.3 Models of Amyloid Seeding in Neurodegenerative Diseases -- References -- Chapter 2 Blood-Brain Barrier and Roots of Entry of Metal Ions into the Brain. Metal Ion Transport and Distribution in the Brain -- 2.1 General Features of Blood-Brain Barrier -- 2.2 Iron and Aluminium -- 2.3 Manganese -- 2.4 Lead and Mercury -- 2.5 The Olfactory Pathway of Metal Entry into the Brain -- 2.6 Astroglia and Metal Accumulation -- References -- Chapter 3 Metal Ion-Induced Redox Reactions, Oxidative Stress and Possible Impact on Neurodegeneration -- 3.1 Metal Induced Production of ROS -- 3.2 Nitric Oxide -- 3.3 Oxidative Stress and Aging -- 3.4 ROS, Protein Oxidation and Aberrant Protein Interactions -- 3.5 Peroxidation of Lipids in Aging Brain -- 3.6 Impact of Oxidative Stress on DNA -- 3.7 ROS and Cell Death -- References -- Chapter 4 Copper Metabolism in the Brain -- 4.1 Introduction -- 4.2 Models of Copper Metabolism -- 4.3 Mammalian Copper Homeostasis -- 4.4 Mammalian Cellular Copper Metabolism -- 4.5 Neurodegenerative Diseases and Copper -- 4.6 Wilson's and Menkes' Diseases -- 4.7 Familial Amyotrophic Lateral Sclerosis -- 4.8 Conclusions -- References -- Chapter 5 Lithium, A Neuroprotective Element -- 5.1 IMPase -- 5.2 GSK-3 -- References -- Chapter 6 Neurotoxicity of Aluminium -- 6.1 Neurochemistry of Aluminum -- 6.2 Aluminum and the Etiology of Alzheimer's Disease -- References -- Chapter 7 Manganese in the Brain Functioning -- 7.1 Introduction -- 7.2 Manganese Absorption.
,
7.3 Manganese Transport to the Brain -- 7.4 Manganese Uptake in the Brain -- 7.5 Proteins that Utilise Manganese -- 7.6 Manganese Neurotoxicity -- 7.7 Effects on Brain Function -- 7.8 Neurological Disease Related to Manganese -- 7.9 Conclusions -- References -- Chapter 8 Alzheimer's Disease: Which Metal Now? -- 8.1 Amyloid Precursor Protein -- 8.2 Cleavage of APP and Formation of β-Amyloid -- 8.3 Neurofibrillary Tangles -- 8.4 Copper, APP and Aβ -- 8.5 Metals and Alzheimer's Disease -- 8.6 A Balance Between Copper and Zinc -- 8.7 The Rise of Iron -- 8.8 Any More Metals in Alzheimer's Disease? -- 8.9 Coordination Chemistry of Metal Ions Interacting with APP -- References -- Chapter 9 Prion Diseases and Redox Active Metals -- 9.1 Introduction -- 9.2 Cu-Binding to PrPc -- 9.3 Details of Cu2+ Co-Ordination to Mammalian PrPC and its Fragments -- 9.3.1 Binding of Cu2+ Ion by a Single Octapeptide Repeat Pro-His-Gly-Gly-Gly-Trp-Gly-Gln -- 9.3.2 pH-Dependence of Cu2+ Binding to Octapeptide Fragment -- 9.3.3 Binding of Cu2+ Ions to Dimeric and Tetrameric Octapeptide Fragments -- 9.4 The Fifth and Sixth Binding Sites Located in N-Terminal Domain -- 9.5 Binding of Cu2+ and Other Metals to PrP91-126 Region Cu(II) Coordination to PrP106-126 (KTNMKHMAGAAAAGAVVGGLG) -- 9.5.1 Involvement of His-96 in the Interaction of Cu(II) with the Neurotoxic Peptide Fragment -- 9.5.2 The Comparison of the Binding Abilities of Octameric and Neurotoxic Regions Toward Cu2+ Ions -- 9.6 Cu2+ Coordination to Chicken PrP -- 9.7 Copper Mediated PrP Internalization -- 9.8 Copper Transport -- 9.9 PrP as an Antioxidant -- 9.10 Manganese Binding -- 9.11 Cell Death and Metals -- 9.11.1 Direct Effects -- 9.11.2 Indirect Effects -- 9.11.3 Combined Effects -- 9.11.4 Age Effects -- 9.12 Metal Changes in TSEs -- 9.13 Copper and Mutant Prions -- 9.14 Conclusions -- References.
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Chapter 10 Are Metals Involved in Cu-Zn Superoxide Dismutase-Related Familial Amyotrophic Lateral Sclerosis -- References -- Chapter 11 Parkinson's Disease: Any Role for Metals -- 11.1 Introduction -- 11.2 Cell Death in Parkinson's Disease -- 11.3 Genetics of Parkison's Disease -- 11.4 The Proteins Associated with Parkinson's Disease -- 11.4.1 Parkin -- 11.4.2 α-Synuclein -- 11.5 Metals in Parkinson's Disease -- 11.6 Bioinorganic Chemistry in Parkinson Disease -- 11.6.1 Binding of Copper Ions to α-Synuclein and its Fragments -- 11.7 Metal Ions and Catecholamines -- 11.8 The Neuromelanin of Substantia Nigra and Metal Ions -- 11.9 Conclusions -- References -- Chapter 12 Chelating Agents in Metal Neurotoxicity -- 12.1 Copper -- 12.2 Lead -- 12.3 Mercury -- 12.4 Iron -- References -- Chapter 13 Metal Complexes in the Brain Imaging and Diagnosis -- 13.1 Gadolinium Compounds -- 13.2 Monocrystalline Iron Oxide Nanocompounds -- 13.3 Delivery of MRI Contrast Agents -- 13.4 MRI Staining of the Hippocampal System -- 13.5 Contrast Agents in Stem Cells Therapy -- 13.6 Thallium Autometallography -- 13.7 Targeting of Contrast Agents to AD Amyloid Plaques -- References -- Subject Index.
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