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  • 1
    Electronic Resource
    Electronic Resource
    Transport properties of sputtered W/C multilayers in high fields (1997)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 81 (1997), S. 1820-1824 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this article, we present the transport properties of W/C multilayers which are generally studied for their optical properties (X-ray mirrors). For the thinnest tungsten layers the magnetoresistance is clearly governed by weak localization. We point out the importance of electron-electron interactions. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.364038
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence for two-dimensional conductivity in the normal state of GdBaCuO thin films
    Amsterdam : Elsevier
    Physica C: Superconductivity and its applications 180 (1991), S. 168-171 
    Details
    ISSN: 0921-4534
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-4534(91)90658-L
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  • 3
    Electronic Resource
    Electronic Resource
    A magnetic study of the one dimensional Sr $\mathsf{_{3}}$ NiIrO $\mathsf{_{6}}$ compound (2003)
    Springer
    The European physical journal 35 (2003), S. 317-323 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. The magnetic properties of a polycrystalline Sr3NiIrO6 sample have been investigated by means of susceptibility and magnetization measurements. On the one hand, it is found that this compound, made of magnetic chains on a triangular lattice, behaves very similarly to Ca3CoRhO6 and Ca3CoIrO6. In particular, at low temperature ( T 〈 T 2 ( = 21 K)), a frozen state, characterized by a very slow spin dynamic, is evidenced. On the other hand, for T 2 〈 T 〈 T 1 ( = 70 K), this phase exhibits magnetization values, smaller than the expected ones, with a 1/3 plateau reminiscent of the ferrimagnetic state of Ising spins on a triangular lattice. Nonetheless, the absence of saturation in 35 T and the low magnetization values are consistent with an antiferromagnetic intrachain coupling between Ir4+ (S = 1/2) and Ni2+ (S = 1). Sr3NiIrO6 can be viewed as made of antiferromagnetically coupled ferrimagnetic chains on a triangular lattice. On the basis of these results, a magnetic (H, T) phase diagram is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjb/e2003-00283-3
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  • 4
    Electronic Resource
    Electronic Resource
    Total colonic aganglionosis: surgical treatment and long-term follow-up (1991)
    Springer
    Pediatric surgery international 6 (1991), S. 198-201 
    Details
    ISSN: 1437-9813
    Keywords: Total colonic anganglionosis ; Hirschsprung's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Between 1966 and 1989, 165 cases of Hirschsprung's disease, of which 20 (12.1%) were total colonic aganglionosis, were surgically treated at our centre. In the first period up to 1978, in which total parenteral nutrition (TPN) was not used or was used with reservations, 6 of 11 patients died. From 1978 to 1989, 9 further cases were treated with the support of TPN and only 1 death occurred, in a child with anganglionosis up to one-half of the jejunum. The 13 surviving patients were treated with the Duhamel or Rehbein techniques; the Lester Martin procedure was not used. There were no notable complications. Follow-up of 10 of these patients, 2 of whom are now 20 years old, showed their general condition, height, weight, and food tolerance to be within normal limits. The number of daily bowel movements, on the average three, was higher than normal. Studies of serum iron transferrin, transferrin saturation, and vitamin B12 and folic acid absorption showed slightly low values that did not affect the erythrocyte count, hemoglobin, or hematocrit, but which require close monitoring. Hydrogen and fecal tests were normal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176068
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  • 5
    Electronic Resource
    Electronic Resource
    Changes in growth, growth hormone, and insulin-like growth factor-I (IGF-I) after orthotopic liver transplantation (1998)
    Springer
    Pediatric surgery international 13 (1998), S. 323-326 
    Details
    ISSN: 1437-9813
    Keywords: Key words Orthotopic liver transplantation ; Growth failure ; Chronic liver disease ; Growth hormone ; Insulin-like growth factor-I
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Growth failure is an important consequence of chronic liver disease in childhood. Insulin-like growth factor-I (IGF-I), which is synthesized and released by the liver, plays an important role as a growth regulator in humans. We examined the growth hormone (GH)/IGF-I axis before and after orthotopic liver transplantation (LT) in 14 children aged between 2 and 11 years (mean 5.6 ± 1.1 years). Pre-transplantation serum GH levels (7.5 ± 1.2 ng/ml) were significantly higher (P 〈 0.001) compared with controls (5 ± 0.5 ng/ml). However, post-transplantation levels (1.8 ± 0.8 ng/ml) did not differ from those in the control group. Serum IGF-I levels showed a statistically significant increase after LT (20.1 ± 9.4 vs 190 ± 66.2 ng/ml; P 〈 0.001) and became indistinguishable from the levels in the control group (180 ± 96 ng/ml). In comparison with pre-transplantation data (z− 2.70), there was an increase in height 4 years postoperatively (z− 1.68). Catch-up growth was highly significant, in particular during the 1st year after LT (z−1.58 ± 1.63 vs 2.59 ± 5.29; P 〈 0.01). We conclude that a GH resistance state found in patients with severe chronic liver disease reverted following LT. Given that IGF-1 depends upon liver function, this could be one of the main factors in the significant catch-up growth in pediatric LT recipients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003830050330
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  • 6
    Electronic Resource
    Electronic Resource
    Conservative treatment of caustic esophageal injuries in children: 20 years of experience (1999)
    Springer
    Pediatric surgery international 15 (1999), S. 323-325 
    Details
    ISSN: 1437-9813
    Keywords: Key words Caustic esophageal stenosis ; Caustic ingestion ; Dilatation procedures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The authors present their experience in the medical treatment of 1,296 caustic esophageal injuries in children over the last 20 years in two study groups, one comprising the period up to 1989 and the other 1990 to 1996, comparing the different treatments used in each group. The treatment was based fundamentally on dilatations with anterograde mercury bougies, Savary bougies, or retrograde thread-guided bougies with gastrostomy. Pneumatic balloons or stenting procedures have also been employed in the last 3 years. Early fiberendoscopy was used systematically in the second group, which provides a more accurate evaluation of the esophageal lesions. Antibiotic coverage was done systematically during the first 10 days in all serious cases, while steroids were employed routinely only in the last 3 years. The results were similar in both groups, with a dilatation average of 32 in the first and 30 in the second group and an initial dilatation interval of 3 to 4 weeks in both. Using updated exploration and dilatation techniques, we drastically reduced the number of gastrostomies needed for retrograde thread-guided dilatations from 51 in the first group to 5 in the second, consequently improving the patients' life quality. There was no mortality and only five esophageal perforations, which did not require surgical treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003830050591
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  • 7
    Electronic Resource
    Electronic Resource
    Shunt surgery for treatment of portal hypertension in children (1985)
    Springer
    World journal of surgery 9 (1985), S. 258-268 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La dérivation portale chez les enfants atteints d'hypertension portale constitue une méthode immédiate et définitive de prévention des hémorragies digestives récidivantes. Les conditions les plus favorables sont les suivantes: a) foie normal; b) veines disponibles dans le secteur porte pour l'anastomose; c) gradient de pression suffisant entre le système porte et le système cave et d) équipe entraînée à la chirurgie portale. Lorsque l'hypertension portale est un épiphénomène au cours d'une affection hépatique sévère, d'autres méthodes d'hémostase des varices oesophagiennes rompues doivent être envisagées. La décision du choix thérapeutique à adopter est difficile lorsqu'il existe une atteinte hépatique, sans altération hépatocellulaire majeure, mais de pronostic incertain à long terme. Quelques années encore seront nécessaires avant de pouvoir affirmer que la dérivation représente la meilleure opération pour traiter ce type d'hypertension portale.
    Abstract: Resumen La cirugía derivativa (“shunts” portosistémicos) en los niños que sufren de hipertensión portal es considerada como una forma inmediata y definitiva de prevenir la hemorragia gastrointestinal recurrente. Ciertas condiciones deben existir para su realization: (a) hígado normal; (b) venas disponibles dentro del sistema porta; (c) suficiente gradiente en las presiones portosistémicas; y (d) disponibilidad de un equipo quirúrgico con experiencia en cirugía venosa portal. Otros medios de hemostasis de las várices esofágicas sangrantes deben ser utilizados en aquellos pacientes en quienes la hipertensión portal es un epifenómeno de enfermedad hepática severa. La decisión más difícil se presenta en el niño con alteraciones hepáticas específicas pero sin mayor disfunción hepatocelular en quien no se puede determinar con precisión el pronóstico. Todavía serán necesarios unos años más antes de poder afirmar que la cirugía derivativa representa la mejor escogencia para esta categoría de pacientes.
    Notes: Abstract Shunt surgery in children suffering from portal hypertension (PH) is considered as an immediate and definite mode of prevention of recurrent gastrointestinal hemorrhage. Certain conditions must be met: (a) normal liver; (b) normal veins available within the portal system; (c) a sufficient portosystemic gradient of pressure; and (d) a surgical team with experience in portal venous surgery. In patients in whom PH is an epiphenomenon of severe liver disease, other means of hemostasis for bleeding esophageal varices should be sought. The difficult decision is in the child with specific liver alterations without major hepatocellular dysfunction but in whom the prognosis cannot be precisely foreseen. A few more years will be needed before one can tell if shunt surgery is the best choice for this category of patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01656319
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  • 8
    Electronic Resource
    Electronic Resource
    Measurements ofH c2(T) in Bi-Sr-Cu-O (1994)
    Springer
    Journal of superconductivity 7 (1994), S. 279-282 
    Details
    ISSN: 1572-9605
    Keywords: Upper critical field ; BiSrCuO ; anomalous critical field ; H c2(T)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract H c2(T) has been measured for thin BSCO films at temperatures down to 65 mK and pulsed fields up to 35 T.H c2(T) diverged anomalously as the temperature decreased. At the lowest temperature, it was five times that expected for a conventional superconductor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00724552
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  • 9
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    Advanced PDGFRA-Mutant GIST (2012)
    The American Association for Cancer Research (AACR)
    Details
    Publication Date: 2012-08-16
    Description: Purpose: Platelet-derived growth factor receptor-alpha ( PDGFRA ) mutations are found in approximately 5% to 7% of advanced gastrointestinal stromal tumors (GIST). We sought to extensively assess the activity of imatinib in this subgroup. Experimental Design: We conducted an international survey among GIST referral centers to collect clinical data on patients with advanced PDGFRA -mutant GISTs treated with imatinib for advanced disease. Results: Fifty-eight patients were included, 34 were male (59%), and median age at treatment initiation was 61 (range, 19–83) years. The primary tumor was gastric in 40 cases (69%). Thirty-two patients (55%) had PDGFRA -D842V substitutions whereas 17 (29%) had mutations affecting other codons of exon 18, and nine patients (16%) had mutation in other exons. Fifty-seven patients were evaluable for response, two (4%) had a complete response, eight (14%) had a partial response, and 23 (40%) had stable disease. None of 31 evaluable patients with D842V substitution had a response, whereas 21 of 31 (68%) had progression as their best response. Median progression-free survival was 2.8 [95% confidence interval (CI), 2.6–3.2] months for patients with D842V substitution and 28.5 months (95% CI, 5.4–51.6) for patients with other PDGFRA mutations. With 46 months of follow-up, median overall survival was 14.7 months for patients with D842V substitutions and was not reached for patients with non-D842V mutations. Conclusions: This study is the largest reported to date on patients with advanced PDGFRA -mutant GISTs treated with imatinib. Our data confirm that imatinib has little efficacy in the subgroup of patients with D842V substitution in exon 18, whereas other mutations appear to be sensitive to imatinib. Clin Cancer Res; 18(16); 4458–64. ©2012 AACR .
    Print ISSN: 1078-0432
    Electronic ISSN: 1557-3265
    Topics: Medicine
    Published by The American Association for Cancer Research (AACR)
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  • 10
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    Adjuvant therapy in primary GIST: state-of-the-art (2012)
    Oxford University Press
    Details
    Publication Date: 2012-10-23
    Description: Background The management of primary gastrointestinal stromal tumours (GISTs) has evolved with the introduction of adjuvant therapy. Recently reported results of the SSG XVIII/AIO trial by the Scandinavian Sarcoma Group (SSG) and the German Working Group on Medical Oncology (AIO) represent a significant change in the evidence for adjuvant therapy duration. The objectives of this European Expert Panel meeting were to describe the optimal management and best practice for the systemic adjuvant treatment of patients with primary GISTs. Materials and methods A panel of medical oncology experts from European sarcoma research groups were invited to a 1-day workshop. Several questions and discussion points were selected by the organising committee prior to the conference. The experts reviewed the current literature of all clinical trials available on adjuvant therapy for primary GISTs, considered the quality evidence and formulated recommendations for each discussion point. Results Clinical issues were identified and provisional clinical opinions were formulated for adjuvant treatment patient selection, imatinib dose, duration and patient recall, mutational analysis and follow-up of primary GIST patients. Adjuvant imatinib 400 mg/day for 3 years duration is a standard treatment in all patients with significant risk of recurrence following resection of primary GISTs. Patient selection for adjuvant therapy should be based on any of the three commonly used patient risk stratification schemes. R1 surgery (versus R0) alone is not an indication for adjuvant imatinib in low-risk GIST. Recall and imatinib restart could be proposed in patients who discontinued 1-year adjuvant imatinib within the previous 3 months and may be considered on a case-by-case basis in patients who discontinued within the previous year. Mutational analysis is recommended in all cases of GISTs using centralised laboratories with good quality control. Treatment is not recommended in an imatinib-insensitive D842V-mutated GIST. During adjuvant treatment, patients are recommended to be clinically assessed at 1- to 3-month intervals. Upon discontinuation, computed tomography scan (CT) scans are recommended every 3 to 4 months for 2 years when the risk of relapse is highest, followed by every 6 months until year 5 and annually until year 10 after treatment discontinuation. Conclusions Key points in systemic adjuvant treatment and clinical management of primary GISTs as well as open questions were identified during this European Expert Panel meeting on GIST management.
    Print ISSN: 0923-7534
    Electronic ISSN: 1569-8041
    Topics: Medicine
    Published by Oxford University Press
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