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  • 1
    Electronic Resource
    Electronic Resource
    Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ (1994)
    Springer
    Acta neuropathologica 89 (1994), S. 35-41 
    Details
    ISSN: 1432-0533
    Keywords: Key words     Alzheimer's disease ; Cell death ; DNA fragmentation ; β-Amyloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract      Loss of nerve cells is a hallmark of the pathology of Alzheimer's disease (AD), yet the patterns of cell death are unknown. By analyzing DNA fragmentation in situ we found evidence for cell death not only of nerve cells but also of oligodendrocytes and microglia in AD brains. In average, 30 times more brain cells showed DNA fragmentation in AD as compared to age-matched controls. Nuclear alterations suggestive of apoptosis were rare in degenerating cells. Even though the majority of degenerating cells were not located within amyloid deposits and did not contain neurofibrillary tangles, neurons situated within areas of amyloid deposits or affected by neurofibrillary degeneration revealed a higher risk of DNA fragmentation and death than cells not exposed to these AD changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294257
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In situ hybridization with digoxigenin-labeled probes: sensitive and reliable detection method applied to myelinating rat brain (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 581-587 
    Details
    ISSN: 1432-0533
    Keywords: Non-radioactive in situ hybridization ; Proteolipid protein ; Myelin basic protein ; Myelin-associated glycoprotein ; 2′3′-Cyclic nucleotide 3′-phosphodiesterase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method for in situ hybridization of digoxigenin-labeled cDNA and cRNA probes to myelin protein mRNA is described. This technique has dual advantages of high structural resolution and high sensitivity and avoids problems associated with handling of radioactive materials. Furthermore, it can be readily combined in double labeling with immunocytochemical protein detection. We have used this technique to detect and locate mRNA for myelin basic protein (MBP), proteolipid protein (PLP), 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) and myelin-associated glycoprotein (MAG) in oligodendrocytes of 7-day-old and adult rat brains. PLP and MAG mRNA were restricted to the perinuclear cytoplasm, whereas MBP and CNPase mRNA was additionally present in peripheral oligodendrocyte processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227734
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 35-41 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; Cell death ; DNA ; tragmentation ; β-Amyloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Loss of nerve cells is a hallmark of the pathology of Alzheimer's disease (AD), yet the patterns of cell death are unknown. By analyzing DNA fragmentation in situ we found evidence for cell death not only of nerve cells but also of oligodendrocytes and microglia in AD brains. In average, 30 times more brain cells showed DNA fragmentation in AD as compared to age-matched controls. Nuclear alterations suggestive of apoptosis were rare in degenerating cells. Even though the majority of degenerating cells were not located within amyloid deposits and did not contain neurofibrillary tangles, neurons situated within areas of amyloid deposits or affected by neurofibrillary degeneration revealed a higher risk of DNA fragmentation and death than cells not exposed to these AD changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294257
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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