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  • 1
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe the target-controlled administration of propofol and remifentanil, combined with monitoring of the bispectral index, during an awake craniotomy for removal of a left temporo-parietal tumour near the motor speech centre. Target concentrations of the two drugs were adjusted according to the patient's responses to painful stimuli and surgical events, and the need for speech testing. Allowing the effect-site concentrations of propofol and remifentanil to decrease during surgery allowed the performance of cortical speech mapping and the testing of the patient's ability to speak. Although the bispectral index was not used as a guide for the administration of the drugs, its value correlated better with the patient's responsiveness than did the predicted effect-site concentrations of propofol. Side-effects, comprising hypotension, respiratory depression and airway obstruction, were related to rapid increases in drug infusion rates and were easily managed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 91 (1988), S. 1-11 
    ISSN: 0942-0940
    Keywords: Brain stem reflex ; coma scale ; head injury ; logistic regression ; motor response ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 1982, we developed a new coma scale, the Glasgow-Liege Scale (GLS), which combines the Glasgow coma scale (GCS) with the quantified analysis of five brain stem reflexes. After severe head injury, the two most important parameters for determining the degree of encephalic disturbances are motor responses (M) and brain stem reflexes (R). The object of this study was to further evaluate the prognosis ability of M and R on admission and during the first month after injury. The study is based on 141 patients. The highest score, during the first day, was less than or equal to 7 on the GCS and 12 on the GLS. Using a multiple group logistic discriminant analysis, we confirmed that, in the first 24 hours, the study of brain stem reflexes appears to be the one factor with the best prognostic ability. We also showed that the prognostic value of certain signs is optimal for a limited period. If, within the two variables M and R, recovery follows an identical pattern whatever the final outcome may be, the restructing speed differs for each outcome. M follows an exponential curve spread over a long period explaining its importance in the course of time. On the other hand, R follows a linear model with straight lines more or less parallel for each outcome. R evolves over a short period of time. These clinical findings give us the opportunity to discuss the physio-pathology of head injury.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 11 (1985), S. 186-191 
    ISSN: 1432-1238
    Keywords: Head injury ; Outcome prediction ; Logistic discrimination ; Prognostic factors ; Risk index ; CK-BB isoenzyme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the problem of outcome prediction from seven risk factors in 40 severely head injured patients-13 favorable and 27 unfavorable outcomes. By applying stepwise logistic discriminant analysis to the patients' data, we selected three significant risk variables: cerebrospinal fluid (CSF) CK-BB isoenzyme activity recorded on admission, severely raised intracranial pressure (more than 40 mmHg) and age, respectively. CSF CK-BB activity, which quantifies the initial neurological damage, proved to be the best prognostic factor. The presence of severe intracranial hypertension was always associated with a bad outcome, whereas its absence was not necessarily indicative of good prognosis. Finally, we combined the three selected variables into a single risk index, which allowed correct predictions in 92% of patients with favorable outcome and in 85% of patients with unfavorable outcome (total predictive efficiency 88%).
    Type of Medium: Electronic Resource
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