ISSN:
1432-1041
Keywords:
blood flow
;
calcitonin
;
calcitonin gene-related peptide
;
duplex-scan
;
laser Doppler
;
healthy volunteers
;
cerebral blood flow
;
skin blood flow
;
intestinal blood flow
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In normal human subjects (n=6), blood flow in the common carotid artery, assessed with an ultrasonic duplex-scanning unit, was increased up to 152% of basal levels by 60-min infusions of human calcintonin gene-related peptide I (αCGRP) 80 pmol·kg−1·h−1, but it was not affected by 20 pmol·kg−1·h−1 CGRP or 88 pmol·kg1·h−1 human calcitonin. In the superior mesenteric artery, on the other hand, blood flow was reduced by 80 pmol·kg−1·h−1 CGRP to 58% of the basal level, but not by 20 pmol·kg−1·h−1 CGRP or with 88 pmol·kg−1·h−1 calcitonin. Blood flow in the abdominal aorta remained largely unchanged under the same conditions. Skin blood flow, assessed by a laser Doppler unit, was increased up to 682% of the basal level by 80 pmol·kg−1·h−1 CGRP, but not by 20 pmol·kg−1·h−1 CGRP or calcitonin. Thus CGRP increased regional blood flow to the brain and the skin at the expense of the gastrointestinal tract.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00280942
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