Keywords:
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (243 pages)
Edition:
1st ed.
ISBN:
9783805586290
Series Statement:
Chemical Immunology and Allergy Series ; v.94
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=475116
DDC:
616.97
Language:
English
Note:
Cover -- Contents -- Preface: Role of T-Cell Subtypes in Allergic Inflammations -- Th17 and Treg Cells Innovate the Th1/Th2 Concept and Allergy Research -- Abstract -- General Role of T Cells in the Immune System -- Treg Cells and Their Importance in Allergy -- Th17 Cells - Proinflammatory Cousins of Treg Cells? -- Origin of T-Cell Phenotypes -- Future and Perspective -- Acknowledgements -- References -- Regulatory T Cells and Antigen-Specific Tolerance -- Abstract -- Characteristics of Regulatory T Cells -- Intra- and Extrathymic Generation of Tregs -- Function of Tregs -- Concluding Remarks -- References -- Molecular Mechanisms of Regulatory T-Cell Development -- Abstract -- Role of Foxp3 in TR Cell Function -- Molecular Mechanisms of nTR Cell Development in the Thymus -- Function of Foxp3 in nTR Cell Development -- Transcriptional Regulation by Foxp3 -- The Foxp3 Transcriptional Program and the TR Cell Transcriptosome -- Transcriptional Regulation of Foxp3 -- nTR versus iTR Cells -- Heritable Disorders of TR Cells -- TR Cell-Directed Therapeutic Interventions in Allergy and Autoimmunity -- Concluding Remarks -- References -- Interaction of Regulatory T Cells with Antigen-Presenting Cells in Health and Disease -- Abstract -- Dendritic Cells and Regulatory T Cells -- Maturation Status of Dendritic Cells Is Critical for Induction of Regulatory T Cells -- Regulatory T Cells Suppress DC Maturation -- Monocytes/Macrophages and Regulatory T Cells -- B Cells and Regulatory T Cells -- Interaction between DCs and Regulatory T Cells during Allergic and Inflammatory Reactions -- Conclusion -- References -- Mucosal Regulatory T Cells in Airway Hyperresponsiveness -- Abstract -- Respiratory Tolerance -- Asthma -- Measuring AHR -- AHR in Asthma -- Studying AHR in Animal Models -- Inhibiting AHR in Animal Models -- Treg Populations.
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Role of Treg in Inhibiting AHR -- Role of Treg in Human AHR -- Therapeutic Means of Inhibiting AHR in Asthma -- Conclusions -- References -- Natural Killer Cells in Allergic Inflammation -- Abstract -- Human Natural Killer Cell Subtypes -- Lysis by NK Cells -- NK Cells and Cytokines -- NK Cells in Allergy -- Concluding Remarks -- References -- Mast Cells and Mast Cell-Derived Factors in the Regulation of Allergic Sensitization -- Abstract -- Skin Models Implicate a Role for Mast Cells in Priming of Adaptive Immune Responses and Allergic Sensitization -- Mast Cells Initiate and Modulate T-Cell Responses during Allergic Airway Inflammation -- Novel and Distinct Roles for Basophils in Allergy -- Conclusion -- Acknowledgements -- References -- Regulatory Effects of Histamine and Histamine Receptor Expression in Human Allergic Immune Responses -- Abstract -- Molecular Basis for Action -- Histamine Receptors -- Synthesis and Metabolism of Histamine -- Histamine in Chronic Inflammatory Responses -- Role of Histamine in the Regulation of Immune Response -- Antigen-Presenting Cells -- Effect of Histamine on T Cells and Antibody Isotypes -- Role of Histamine and H1 Antihistamines during Allergen-SIT -- Use of H1 Antihistamines in Asthma -- Conclusions -- Acknowledgments -- References -- T-Cell Regulation in Asthmatic Diseases -- Abstract -- New Molecular Target for Allergic Asthma -- Interleukin-6 as a Bridge between Innate and Adaptive Immune Responses -- Interaction of Th2 and T-Regulatory Cells -- Do Th17 Cells Counteract T-Regulatory Cells in Allergic Asthma? -- T-Bet Deficiency: Genetic and Epigenetic Control in Allergic Asthma -- Glucocorticoid Receptor and T-Cell-Specific Transcription Factors -- Conclusions -- Acknowledgment -- References -- Immune Regulatory Mechanisms in Allergic Contact Dermatitis and Contact Sensitization -- Abstract.
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Contact Hypersensitivity and Animal Model of Tolerance to Haptens -- T-Regulatory Cells in Contact Allergy -- Dendritic Cells as Orchestrators of Skin Immune Responses to Haptens -- Conclusions -- References -- Regulatory Role of T Lymphocytes in Atopic Dermatitis -- Abstract -- Regulation of Atopic Dermatitis by T Cells - Clinical Aspects -- T Lymphocytes Dominate the Cellular Infiltrate in Atopic Dermatitis -- Role of Adaptive Immune Responses in Atopic Dermatitis Involving IgE Responses -- Aeroallergen-Specific T Cells Are Well-Known Initiators and Perpetuators of Eczematous Responses in Atopic Dermatitis -- Food-Specific T Cells Are Involved in Allergic Responses in Atopic Dermatitis in Children and Adults -- T Cells May Contribute to the Defects in Innate Immune Response in Atopic Dermatitis -- Microorganism Activate T Lymphocytes and Bystander Cells in the Skin in Atopic Dermatitis -- Are T Cells Involved in Specific Immune Responses to Autoantigens in Atopic Dermatitis? -- Cellular and Molecular Interactions of T Cells in Atopic Dermatitis -- T Cells Communicate with Vascular Cells, Proinflammatory Cytokines and Chemokines in the Skin -- Do CD8+ T Cells Play a Role in Atopic Dermatitis? -- T Cells Secrete Different Cytokines at Different Stages in Atopic Dermatitis -- T Lymphocytes Regulate the Cutaneous Cytokine Milieu in Atopic Dermatitis -- Th-2 Cytokines Have Numerous Effects on Cutaneous Cells in Atopic Dermatitis -- Do Th-17 Lymphocytes Contribute to Eczema in Atopic Dermatitis? -- Role of Regulatory T Cells in Atopic Dermatitis -- T Cells Interact with Keratinocytes in Atopic Dermatitis -- Concluding Remarks -- References -- T-Cell Regulation in Helminth Parasite Infections: Implications for Inflammatory Diseases -- Abstract -- Epidemiology of Helminth Infections, Allergies and Autoimmune Pathologies.
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Immune Regulation in Human Helminth Infections -- Experimental Evidence for Immune Regulation in Animal Models -- Models of Allergies and Autoimmunity - Helminths Acting Through T Cells? -- Helminths and the Innate Immune System -- Learning from Helminths to Treat Allergy and Autoimmunity -- Acknowledgements -- References -- Immune Regulation and Tolerance to Fungi in the Lungs and Skin -- Abstract -- Fungal Diseases -- Features of Fungal Diseases -- Immunity to Fungi: Connecting the Innate to the Adaptive Immune System through DCs -- Innate Immunity -- Dendritic Cells -- Adaptive Th Immunity -- Driving Inflammation: Contribution of the Th17 Pathway -- Dampening Inflammation and Allergy to Fungi: The Role of Treg Subsets -- Tryptophan Catabolism and Allergy: Fungi Are Next in Line -- Paradigm of Reverse and Noncanonical in Fungal Infections -- R& -- N in Fungal Infections Is Not Toll-Free and Is Exploited by Corticosteroids -- Can IDO Help in the Fight Against Fungal Allergy? -- Conclusion: Targeting R& -- N-Mediated Immune Homeostasis in Fungal Allergy -- Acknowledgements -- References -- Control of Delayed-Type Hypersensitivity by Ocular-Induced CD8+ Regulatory T Cells -- Abstract -- Suppression of Cell-Mediated Immunity by CD8+ Regulatory T Cells -- Suppressor T Cells Redux -- Suppression of the DTH Response -- Induction of Splenic CD8+ Suppressor T Cells via the Eye's Anterior Chamber -- Afferent and Efferent Mechanisms for Ocular-Induced CD8+ Regulatory T Cells -- Antigen Specificity of the Suppression of DTH by CD8+ Regulatory T Cells -- Qa-1b Restriction of CD8+ Suppressor T-Cell-Mediated Suppression -- IFN-gamma Facilitates the Suppression of DTH by Splenic CD8+ Suppressor T Cells -- TGF-beta Is a Mechanism of CD8+ Treg-Mediated Suppression of DTH -- Conclusion -- Acknowledgements -- References.
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Novel Therapeutic Strategies by Regulatory T Cells in Allergy -- Abstract -- Role of T-Regulatory Cells in Inhibiting Allergic Diseases -- Implications from Mouse Models -- Evidence for Targeting Treg Cells -- Therapeutic Strategies for Modulating Treg Activity in Allergy -- Induction of Treg Activity by Peptide-Based Immunotheraphy -- Induction of Treg Activity by Targeting Toll-Like Receptors -- Conclusion -- References -- T-Cell Regulatory Mechanisms in Specific Immunotherapy -- Abstract -- Peripheral T-Cell Tolerance in Allergen-Specific Immunotherapy -- Peripheral T-Cell Tolerance to Allergens Is Associated with Regulation of Antibody Isotypes and Suppression of Effector Cells -- T-Regulatory Cells -- Tr1 Cells -- Th3 Cells -- CD4+CD25+ Treg Cells -- Other T-Regulatory Cells -- B-Regulatory Cells -- Dendritic-Regulating Cells -- Other Cells with a Possible Regulatory Function -- Suppression Mechanisms of T-Regulatory Cells -- Clinical Relevance of T-Regulatory Cells -- cAMP-Stimulating G-Protein-Coupled Receptors in Peripheral Tolerance -- Clinical Evidence for T-Regulatory Function of Histamine Receptors -- Conclusion -- References -- Control and Regulation of Peripheral Tolerance in Allergic Inflammatory Disease: Therapeutic Consequences -- Abstract -- Pathobiology of the Allergic Inflammatory Response -- Regulation of Peripheral T-Cell Tolerance and Aberrations in Allergic Diseases -- T-Cell Anergy -- Suppressive Cytokines (IL-10, TGF-beta) -- Natural and Adaptive Treg Cells -- Mechanisms Promoting the Inflammatory Response in Allergic Diseases -- Tumor Necrosis Factor-alpha -- Thymic Stromal Lymphopoietin -- Interleukin-25 -- Natural Killer T Cells -- Immunotherapeutic Approaches for Regulation of T-Cell Tolerance in Allergic Diseases -- Conclusions and Future Directions -- References.
,
Lung Dendritic Cells: Targets for Therapy in Allergic Disease.
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