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  • 1
    Electronic Resource
    Electronic Resource
    Cellular Acetylcholine Content and Neuronal Differentiation (1997)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 69 (1997), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: N18TG2 neuroblastoma clone is defective for biosynthetic neurotransmitter enzymes; its inability to establish functional synapses is overcome in the neuroblastoma × glioma 108CC15, where acetylcholine synthesis is also activated. These observations suggest a possible relation between the ability to produce acetylcholine and the capability to advance in the differentiation program and achieve a fully differentiated state. Here, we report the characterization of several clones after transfection of N18TG2 cells with a construct containing a cDNA for rat choline acetyltransferase (ChAT). The ability of these clones to synthesize acetylcholine is demonstrated by HPLC determination on cellular extracts. In the transfected clones, northern blot analysis shows increased expression of mRNAs for a specific neuronal protein associated with synaptic vesicles, synapsin I. Fiber outgrowth of transfected clones is also evaluated to establish whether there is any relation between ChAT levels and morphological differentiation. This analysis shows that the transfected clone 1/2, not expressing ChAT activity, displays a very immature morphology, and its ability to extend fibers also remains rather poor in the presence of “differentiation” agents such as retinoic acid. In contrast, clones 2/4, 3/1, and 3/2, exhibiting high ChAT levels, display higher fiber outgrowth compared with clone 1/2 in both the absence and the presence of differentiating agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1997.69041374.x
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Stable changes in CD4+ T lymphocyte miRNA expression after exposure to HIV-1 (2012)
    American Society of Hematology (ASH)
    In: Blood
    Details
    Publication Date: 2012-06-29
    Description: MicroRNAs (miRNAs) inhibit HIV-1 expression by either modulating host innate immunity or by directly interfering with viral mRNAs. We evaluated the expression of 377 miRNAs in CD4 + T cells from HIV-1 élite long-term nonprogressors (éLTNPs), naive patients, and multiply exposed uninfected (MEU) patients, and we observed that the éLTNP patients clustered with naive patients, whereas all MEU subjects grouped together. The discriminatory power of miRNAs showed that 21 miRNAs significantly differentiated éLTNP from MEU patients and 23 miRNAs distinguished naive from MEU patients, whereas only 1 miRNA (miR-155) discriminated éLTNP from naive patients. We proposed that miRNA expression may discriminate between HIV-1–infected and –exposed but negative patients. Analysis of miRNAs expression after exposure of healthy CD4 + T cells to gp120 in vitro confirmed our hypothesis that a miRNA profile could be the result not only of a productive infection but also of the exposure to HIV-1 products that leave a signature in immune cells. The comparison of normalized Dicer and Drosha expression in ex vivo and in vitro condition revealed that these enzymes did not affect the change of miRNA profiles, supporting the existence of a Dicer-independent biogenesis pathway.
    Keywords: Immunobiology
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology (ASH)
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  • 3
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    The MCS intensity distribution of the devastating 24 August 2016 earthquake in central Italy (MW 6.2) (2016)
    Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Details
    Publication Date: 2016-11-15
    Description: Here we describe the macroseismic survey of the 24 August 2016 earthquake in central Italy (M_W 6.2). By applying a revised version of the Mercalli-Cancani-Sieberg scale, we estimated the site intensity in more than 300 localities of Lazio, Abruzzi, Umbria and Marche regions, providing the Civil Protection with a quick and robust snapshot of the earthquake. The most severe effects are focused south of the instrumental epicenter, in the Amatrice intermountain basin, where intensity reached 10-11 MCS. Highest damage (area inside 9 MCS isoseismal) is focused in a NNW-SSE belt of the hangingwall of the causative faults, i.e. the southern segment of the Mount Vettore fault system and the northern segment of the Laga Mounts fault system, with northward damage propagation in the far-field. The intensity dataset allows to evaluate a M_W 6.16±0.5, which is very close to the instrumental magnitude, with a seismogenic box striking N161°, mimicking the geological active faults. Epicentral intensity is I_0 10 MCS, I_MAX 10-11. The elevated level of destruction is mainly due to the high vulnerability of buildings, mostly made by cobblestone masonry. Integrating the macroseismic information with the geological, geodetical and geophysical data it is possible to hypothesize a bidirectional rupture propagation (toward NNW and SSE) along the two different faults. It is also possible to attribute the 1639, M_W 6.0 earthquake to the same source of the southern 2016 rupture (northernmost Laga Mounts faults).
    Print ISSN: 1593-5213
    Topics: Geosciences
    Published by Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 4
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    Hindcast of oil-spill pollution during the Lebanon crisis in the Eastern Mediterranean, July–August 2006 (2012)
    Elsevier Science Limited
    Details
    Publication Date: 2021-06-25
    Description: MOON (Mediterranean Operational Oceanography Network http://www.moon-oceanforecasting.eu) provides near-real-time information on oil-spill detection (ocean color and SAR) and predictions [ocean forecasts (MFS and CYCOFOS) and oil-spill predictions (MEDSLIK)]. We employ this system to study the Lebanese oil-pollution crisis in summer 2006 and thus to assist regional and local decision makers in Europe, regionally and locally. The MEDSLIK oil-spill predictions obtained using CYCOFOS high-resolution ocean fields are compared with those obtained using lower-resolution MFS hydrodynamics, and both are validated against satellite observations. The predicted beached oil distributions along the Lebanese and Syrian coasts are compared with in situ observations. The oil-spill predictions are able to simulate the northward movement of the oil spill, with the CYCOFOS predictions being in better agreement with satellite observations. Among the free MEDSLIK parameters tested in the sensitivity experiments, the drift factor appears to be the most relevant to improve the quality of the results.
    Description: Published
    Description: 140–153
    Description: JCR Journal
    Description: restricted
    Keywords: Lebanese oil-pollution event; Oil-spill modeling; Operational oceanography; Remote sensing; Levantine Basin ; 03. Hydrosphere::03.02. Hydrology::03.02.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 5
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    Hindcast of Oil Spill Pollution during the Lebanon Crisis, July-August 2006 (2010)
    Details
    Publication Date: 2020-10-15
    Description: The Mediterranean Operational Oceanography Network (MOON ) provides near-real-time information on oil spill detection and predictions that have been used during the Lebanese oil pollution crisis in summer 2006. A MOON decision support system for oil spill monitoring and prediction comprising ocean colour satellite and SAR images, ocean current forecast (MFS-Mediterranean Forecasting System and CYCOFOS-CYprus Coastal Ocean Forecasting & Observing System) and the MEDSLIK oil spill model has been developed. The oil spill predictions obtained with MEDSLIK coupled to the CYCOFOS high-resolution ocean fields are compared with the oil spill predictions obtained using the lower resolution MFS hydrodynamics and both are validated against satellite observations. The predicted beached oil quatity along the Lebanese and Syrian coasts are compared with the in-situ observations. It is found that predictions with both CYCOFOS and MFS ar capable to simulate the northward movement of the oil, with the higher resolution CYCOFOS predictions in better agreement with satellite observations. Among the free MEDSLIK oil spill parameters tested in the sensitivity experiments there are the wind corrections (wind factor and angle) and the depth of coupling between eulerian fields and wind correction. Among them the drift factor appeared the most relevant in order to improve the quality of results suggesting that operational models such as MFS and CYCOFOS still lack of enought resolution and physical process at the air-sea interface. The oil moved from Lat 33°40'N Lon 35°24.75'E northward toward Syria, which was reached in 10 days at Lat 34° 38.451'N Lon 35° 58.377'E; the oil movement is followed up to August 6 when the oil reached 35.5°N.
    Description: Not submitted
    Description: 4.6. Oceanografia operativa per la valutazione dei rischi in aree marine
    Description: JCR Journal
    Description: open
    Keywords: Lebanese oil pollution event ; oil spill modelling ; operational oceanography ; remote sensing ; Levantine Basin ; 03. Hydrosphere::03.01. General::03.01.05. Operational oceanography
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: manuscript
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  • 6
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    Hindcast of oil-spill pollution during the Lebanon crisis in the Eastern Mediterranean, July–August 2006 (2011)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: MOON (Mediterranean Operational Oceanography Network http://www.moon-oceanforecasting.eu) pro- vides near-real-time information on oil-spill detection (ocean color and SAR) and predictions [ocean fore- casts (MFS and CYCOFOS) and oil-spill predictions (MEDSLIK)]. We employ this system to study the Lebanese oil-pollution crisis in summer 2006 and thus to assist regional and local decision makers in Europe, regionally and locally. The MEDSLIK oil-spill predictions obtained using CYCOFOS high-resolution ocean fields are compared with those obtained using lower-resolution MFS hydrodynamics, and both are validated against satellite observations. The predicted beached oil distributions along the Lebanese and Syrian coasts are compared with in situ observations. The oil-spill predictions are able to simulate the northward movement of the oil spill, with the CYCO- FOS predictions being in better agreement with satellite observations. Among the free MEDSLIK param- eters tested in the sensitivity experiments, the drift factor appears to be the most relevant to improve the quality of the results.
    Description: The paper was produced using the INGV MFS forecasting-sys- tem product and the OC-UCY CYCOFOS forecasting-system prod- ucts. The MODIS satellite data products were processed at the GOS-CNR-ISAC Rome laboratory using the SeaDAS software devel- oped by NASA GSFC, Greenbelt, Maryland, the HDFLook software developed by The Laboratoire d’Optique Atmosphérique, Univer- sity of Lille, France, and the MS2GT tool box developed by the Uni- versity of Colorado. Procedures for oil-spill detection were developed in the ENVI environment. Processed ENVISAT-ASAR data were made available by Telespazio and JRC. Part of this work was carried out with the support of the PRIMI project (ASI Contract No. I/094/06/0) financed by the Italian Space Agency (ASI).
    Description: In press
    Description: 4.6. Oceanografia operativa per la valutazione dei rischi in aree marine
    Description: JCR Journal
    Description: reserved
    Keywords: Lebanese oil-pollution event ; Oil-spill modeling ; Operational oceanography ; Remote sensing ; Levantine Basin ; 03. Hydrosphere::03.01. General::03.01.05. Operational oceanography
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 7
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    A summary of the formation and seasonal progression of the Northeast Water Polynya (1997)
    In:  EPIC3J Mar Syst, 10, pp. 79-85
    Details
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
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