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  • 1
    Online Resource
    Online Resource
    Hauppauge :Nova Science Publishers, Incorporated,
    Keywords: United States. -- Dept. of Energy -- Rules and practice. ; Reactor fuel reprocessing -- Waste disposal -- United States. ; Radioactive waste disposal -- United States. ; Spent reactor fuels -- Storage -- United States. ; Radioactive waste repositories -- United States. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (61 pages)
    Edition: 1st ed.
    ISBN: 9781613249567
    DDC: 333.7924153
    Language: English
    Note: Intro -- GLOBAL NUCLEAR ENERGYPARTNERSHIP -- GLOBAL NUCLEAR ENERGYPARTNERSHIP -- CONTENTS -- PREFACE -- RESULTS IN BRIEF -- BACKGROUND -- Materials in Spent Nuclear Fuel -- Technologies for Recycling Spent Nuclear Fuel -- DOE'S ORIGINAL ENGINEERING-SCALEAPPROACH WOULD MEET GNEP'SOBJECTIVES IF ADVANCED RECYCLINGTECHNOLOGIES ARE SUCCESSFULLYDEVELOPED -- Successful Development of Advanced RecyclingTechnologies Would Be an Initial Step toward GreatlyExtending the Capacity of a Geologic Repository -- Advanced Recycling Technologies Envisioned underDOE's Original Approach to GNEP Pose LowerProliferation Risks Than Existing Recycling Technologies -- Lack of Industry Participation Could Reduce theProspects for Commercialization and Widespread Use ofAdvanced Recycling Technologies -- DOE's Original Approach to GNEP Included Building aSeparate Engineering-Scale Reprocessing Plant beforeConducting R& -- D that Would Help in Designing the Plant -- The R& -- D Facility and Advanced Reactor Would EnableDOE to Develop the Advanced Recycling TechnologiesEnvisioned under Its Original Approach to GNEP -- DOE'S ACCELERATED APPROACH WOULDLIKELY RELY ON TECHNOLOGIES THAT FALLSHORT OF MEETING GNEP'S OBJECTIVES -- Two Other Industry Consortia Proposed to AddressGNEP's Objectives by Using Technologies That Are NotMature Enough for Commercial Deployment -- The Government Would Likely Bear Substantial Costsfor Commercial-Scale Recycling Facilities -- DOE Officials Recognize the Limitations of AcceleratingDeployment of Commercial-Scale Facilities but CiteOther Benefits -- CONCLUSIONS -- RECOMMENDATIONS FOR EXECUTIVEACTION -- AGENCY COMMENTS AND OUR EVALUATION -- List of Committees -- APPENDIX I.SCOPE AND METHODOLOGY -- APPENDIX II.DOE'S USE OF TECHNOLOGY READINESSLEVELS TO ASSESS THE MATURITY OF SPENTFUEL RECYCLING TECHNOLOGIES -- INDEX.
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 3 (1985), S. 0 
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1540-8183
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: BERNSTEIN, A.D., et al.: The NASPE/BPEG Defibrillator Code. A new generic code, patterned after and compatible with the NASPE/BPEG Generic Pacemaker Code (NBG Code) was adopted by the NASPE Board of Trustees on January 23, 1993. It was developed by the NASPE Mode Code Committee, including members of the North American Society of Pacing and Electrophysiology (NASPE) and the British Pacing and Electrophysiology Group (BPEG). It is abbreviated as the NBD (for NASPE/BPEG Defibrillator) Code. It is intended for describing the capabilities and operation of implanted cardioverter defibrillators (ICDs) in conversation, record keeping, and device labeling, and incorporates four positions designating: (1) shock location; (2) antitachycardia pacing location; (3) means of tachycardia detection; and (4) antibradycardia pacing location. An additional Short Form, intended only for use in conversation, was defined as a concise means of distinguishing devices capable of shock alone, shock plus antibradycardia pacing, and shock plus antitachycardia and antibradycardia pacing. (PACE, Vol. 16, September 1993)
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 599 (1990), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Postsynaptic targeting of the Drosophila tumour suppressor discs-large (Dlg) critically depends on its SH3 and GK domains. Here, we asked whether these domains are also involved in subcellular targeting of the mammalian Dlg homolog SAP97 and its interacting partners in CNS cortical neurons by analysing a recently described mouse mutant lacking the SH3 and GK domains of SAP97. Both wildtype and truncated SAP97 were predominantly expressed in perinuclear regions, in a pattern suggesting association with the endoplasmic reticulum. Weaker immunoreactivity was found in neurites colocalizing with both dendritic and axonal markers. As SAP97 has been implicated in the early intracellular processing of the glutamate receptor GluR1, we studied biochemical maturation and subcellular localization of GluR1 in the mutants. Both the glycosylation pattern and synaptic clustering of GluR1 were indistinguishable from wildtype mice. Synaptic clustering of the guanylate kinase domain interacting protein GKAP was also intact. Our data demonstrate that truncation of the SH3 and GK domains of SAP97 in mice does neither change its subcellular distribution nor does it disrupt synaptic structure or protein clustering, as opposed to severe missorting of the respective mutant Dlg protein in Drosophila.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] To test the behaviour of a mutant form of p53 in the presence and absence of wild–type p53 in vivo, we mated p53–deficient mice containing a p53 null allele to transgenic mice containing multiple copies of a mutant p53 gene (Val 135). Animals hemizygous for the endogenous ...
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature genetics 18 (1998), S. 305-306 
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] If the method for delivering new genes into cells for gene therapy were a new car, what bells and whistles would this year's new car buyers want to see? Clearly, no self-respecting tyre-kicker would choose a gas guzzler that could not deliver genes at high efficiency (and ideally only) into the ...
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: BERNSTEIN, A.D., et al.: The Revised NASPE/BPEG Generic Code for Antibradycardia, Adaptive-Rate, and Multisite Pacing. In light of evolving pacemaker technology and increasing interest in multisite pacing, the Committee on the Development of Position Statements (CDPS) of the North American Society of Pacing and Electrophysiology (NASPE) created an ad hoc Pacemaker Mode Code Task Force in April 2001 under the chairmanship of David L. Hayes, MD, for the purpose of bringing the NASPE/British Pacing and Electrophysiology Group (BPEG) Generic Pacemaker Code (NBG Code) up to date. The task force, whose members are the authors of this article, designed a revised NBG Code in which three major issues were taken into account. First, it was recognized that all modern pacemaker pulse generators are capable of extensive bidirectional communication with an external programming device, making them “communicating” pulse generators as defined by the current (1987) NBG Code. Second, it was decided that a means of providing basic information regarding the location of multisite pacing would be a useful ingredient of the NBG Code. Third, in view of the extensive antibradycardia pacing capabilities common in modern implantable cardioverter defibrillators and the availability of the NASPE/BPEG Defibrillator Code (NBD Code), it was considered unnecessary for the NBG Code to address the presence or absence of antitachycardia features. The resulting updated version of the NBG Code as described herein was endorsed by the BPEG on September 20, 2001 and adopted by the NASPE Board of Trustees on October 18, 2001. The structure of the revised NBG Code differs from that of the previous version in two respects alone: Position IV specifies only the presence or absence of rate modulation, and Position V specifies only the location or absence of multisite pacing (i.e., biatrial or biventricular pacing with at least two stimulation sites in each case) more than one stimulation site in any single cardiac chamber, or any combination of these. The revised NBG Code is deliberately configured to avoid confusion with earlier mode codes, and it is the authors' hope that it will serve as an enhanced resource for communication among those engaged in every phase of the multidisciplinary practice of cardiac rhythm management.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 23 (2000), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In addition to its beneficial effect on patient survival, the implanted cardioverter defibriliator (ICD) changes a patient's life physically, socially, and psychologically. For improved patient management, it is important to understand the quality-of-life changes that accompany this mode of treatment. To this end, 119 patients were surveyed retrospectively and interviewed concurrently regarding their emotional, physical, and behavioral responses to ICD shocks and to the device itself. Most (55%) correctly estimated the total number of shocks they had received within a 10% margin. They found the shocks severe, 79% assigning a score between 3 and 5 on a scale of 1–5. Common descriptions of the shock sensation were a blow to the body or a spasm causing the entire body to jump. Most patients tolerated the shocks as life saving, but 23% dreaded shocks and 5% even said they would rather be without the ICD and take their chances. After a shock, 50% of patients called their physician and 42% continued their daily routine. Thirty percent went to a hospital emergency room or called a rescue service. Sixty-five percent had no preshock prodromes. Fifty-four percent were interested in the programmable option of a warning signal prior to a shock, while 31 % preferred no warning. Of the 74% who were advised not to drive after implantation, 29% drove anyway. Five patients were shocked while driving with no resulting accidents. We conclude that most patients find ICD shocks moderately uncomfortable, but they tolerate them because of the lifesaving protection provided by the device.
    Type of Medium: Electronic Resource
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