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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 47 (1992), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Laterale/zentrale Mittelgesichtsfraktur ; Komplikationen ; Miniplattenosteosynthese ; Key words Lateral/central midfacial fractures ; Complication rate ; Ostesynthesis ; Miniplates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Despite significant progress in the therapy of craniofacial injuries permanent consequences of the trauma are still likely to occur. It has been possible to follow-up 105 (65,2%) of the 161 patients who were treated for lateral and central midfacial fractures in our department between 1989 and 1991. Pathological findings on follow-up were found in 48,6% of our patients. Most frequent were persistent disturbances of the sensitivity in the area of the second branch of the trigeminal nerve (32,4%). Patients who were operated within the first week after trauma did have significantly less sensory disturbances than patients who underwent surgery later. 7,6% of our patients had permanent double vision (4,8% in their primary vision field). After subciliary incision 3% had an ectropium which was not found after transconjunctival incision. There was no significant difference in the cosmetic outcome of the two approaches. In one patient who received silicone for restoration of the orbital floor the plate did migrate. Other materials that were used for orbital floor reconstruction did not cause problems. Based on the post-operative results improvements for the therapeutic regimen are discussed.
    Notes: Zusammenfassung Trotz verbesserter Therapie kommt es nach Gesichtsschädelverletzungen noch immer zu permanenten Traumafolgen. Von 161 Patienten, die mit Frakturen des lateralen und zentralen Mittelgesichts an unserer Klinik zwischen 1989 und 1991 operiert wurden, untersuchten wir 105 (65,2%) auf Folgezustände, um daraus eventuelle Verbesserungen für unser Therapiekozept abzuleiten. Ein pathologischer Befund wurde bei 48,6% der Patienten nachgewiesen. Am häufigsten waren persistierende Sensibilitätsstörungen des 2. Trigeminusastes (32,4%). Dabei hatte Patienten, die innerhalb einer Woche nach dem Trauma operiert wurden, signifikant weniger Sensibilitätsstörungen als die Gruppe, die später operiert wurde. Doppelbildsehen konnte insgesamt in 7,6% nachgewiesen werden (4,8% im Gebrauchsblickfeld). Beim subziliaren Schnitt hatten 3% eine Ektropiumbildung, was beim transkonjunktivalen Schnitt nicht vorkam. Im ästhetischen Resultat wurde kein signifikanter Unterschied gefunden. Ein Fall einer durchgewanderten Silikonfolie trat auf, während die anderen zur Deckung des Orbitabodens verwendeten Materialien keine Komplikationen aufwiesen. Anhand der Ergebnisse werden therapeutische Verbesserungen diskutiert.
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  • 3
    ISSN: 1433-0458
    Keywords: Schlüsselwörter ; Tonsillektomie ; Argon-Plasma-Koagulation (APC) ; Hochfrequenzchirurgie ; Key words ; Tonsillectomy ; Argon-Plasma-Coagulation ; High-frequency surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background: The Argon-Plasma-Coagulation (APC) offers an innovative possibility for the tonsillectomy combined with a high-frequency technology. Aim of our study was to inves-tigate the differences between this high-frequency-technology and the traditional tonsillectomy. No reports exist in the use of the APC in the tonsillectomy. Methods: Argon-Plasma-Coagulation tonsillectomy (TE-APC) was compared with the traditional blunt dissection tonsillectomy (TE-trad) with hemostasis by compression and bipolar coagulation. 133 patients were stratified in two age groups in a clinical prospective randomised study. Results: Average surgical time and blood loss were markedly decreased in the TE-APC group (p〈0,01). There was no significant difference between the two techniques concerning postoperative pain, otalgia, and primary or secondary haemorrhage. In the TE-APC group more extensive fibrin layer appeared after surgery. In the TE-APC patients’ group, there was a slightly higher consume of analgetics in some postoperative days. Conclusions: The one-step dissection and coagulation procedure leads to an almost bloodfree woundground and to a reduction of operation-time. The self-limited and effective coagualative properties of the APC-method leads to a controlled penetration depth. The often associated extensive post operative pain and uncontrolled tissue- damage, known from electrical and lasersurgical techniques, was not found in TE-APC-patients-group.
    Notes: Zusammenfassung Hintergrund: Die Argon-Plasma-Koagulation (APC) bietet eine innovative Möglichkeit eine Tonsillektomie durchzuführen. Wie sich diese Hochfrequenzchirurgietechnik von konventionellen Tonsillektomieverfahren unterscheidet, soll anhand einer Studie untersucht werden. Patienten und Methode: In einer klinisch-prospektiven randomisierten Blindstudie mit 133 Patienten wurde die APC-Tonsillektomie (TE-APC) mit der stumpfen Dissektion, mit Kompression und bipolarer Koagulation zur Primärblutstillung (TE-konv), verglichen. Ergebnis: Der intraoperative Blutverlust und die durchschnittliche Operationsdauer waren bei der TE-APC signifikant erniedrigt (p〈0,01). Kein signifikanter Unterschied lies sich bei dem postoperativen Schmerz, der Otalgia und der aufgetretenen Nachblutungen zwischen den beiden Verfahren feststellen. Bei der TE-APC kam es zu vermehrter Fibrinbelagausbildung und an einzelnen postoperativen Tagen zu einem geringfügig erhöhten Analgetikaverbrauch. Schlußfolgerung: Bei der TE-APC erfolgten Dissektion und Koagulation in einem Schritt, dadurch wurde die Operationsdauer signifikant verkürzt. Durch den selbstlimitierten Effekt der Gewebepenetration der APC wird eine kontrollierte Eindringtiefe in das Gewebe erreicht. Die bei elektro- und laserchirurgischen Techniken üblicherweise festzustellende ausgeprägte postoperative Schmerzsymptomatik fand sich bei der APC-TE nicht.
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  • 4
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Erbium:YAG-Laser ; Dermablation ; Skin ; resurfacing ; Key words Erbium:YAG laser ; Dermal ablation ; Skin resurfacing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The erbium:YAG laser (wavelength 2940 nm; pulse duration 0.350 ms; pulse energy 0.1–1.7 J) allows vaporization of very thin skin layers without scarring and minimal lateral thermal injury due to an extremely short pulse duration. It permits exact ablation of relatively large areas of facial skin. We report our results with 216 patients following treatment for different facial lesions (facial wrinkles, acne scars, syringomas, and circumscribed sebaceous gland hyperplasia) using a new erbium:YAG laser system. Good-to-excellent cosmetic results were obtained in these patients. Our findings show that the erbium:YAG laser is an elegant and promising new method for the treatment of facial lesions.
    Notes: Zusammenfassung Der Erbium:YAG-Laser (2940 nm Wellenlänge; 0,350 ms Pulsbreite; 0,1-1,7 J Pulsenergie) gewährleistet durch seine extrem kurze Impulsdauer eine narbenfreie Ablation sehr dünner Hautschichten mit Minimierung thermisch bedingter Schäden in der Umgebung der behandelten Hautareale. Er erlaubt ein kontolliertes, exaktes Arbeiten und ermöglicht eine großflächige Behandlung der Haut im Gesichtsbereich. Wir berichten über unsere Ergebnisse an 216 Patienten, die wegen verschiedener störender Hautveränderungen im Gesichtsbereich (Hautfältchen, Aknenarben, Syringome, Talgdrüsenhyperplasien) mit dem Erbium:YAG-Laser behandelt wurden und gute bis sehr gute kosmetische Ergebnisse nach der Laserbehandlung zeigten. Wir sehen in der Anwendung des Erbium:YAG-Laser eine elegante und vielversprechende neue Methode zur Behandlung verschiedener Gesichtshautveränderungen.
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  • 5
    ISSN: 1433-0458
    Keywords: Schlüsselwörter APC ; Argon-Plasma-Koagulation ; Plasmachirurgie ; Nasenmuschelhyperplasie ; Morbus Osler ; Larynxpapillomatose ; Key words Argon plasma surgery ; Argon plasma coagulation ; Plasma surgery ; Turbinate hyperplasia ; Osler’s disease ; Laryngeal papillomatosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Cold knife surgery, electrosurgery and laser surgery all offer techniques, instruments, equipment and systems for resecting and destroying mucosal lesions and for hemostasis in the upper aerodigestive tract. When used in the head and neck, argon plasma surgery (APS) offers a new, contact-free, electrosurgical technique in which high-frequency current is applied through ionized, and thus electrically conductive, argon (argon plasma) to the tissue undergoing treatment. Especially noteworthy in APS are its advantages for removing a lesion and controlling bleeding: the technique is easy to control, and the depth of thermal tissue destruction is limited to a maximum of 3 mm even in wide-area application, so that damage to adjacent or submucosal tissues can be avoided. Initial results with APS in the reduction of hyperplastic nasal turbinates, treatment of hereditary hemorrhagic teleangiectasia (Osler’s disease) in the nasal mucosa, and in treating progressive juvenile papillomatosis of the larynx have shown clear advantages for APS over other methods used.
    Notes: Zusammenfassung Zur Resektion oder Destruktion von Läsionen der Schleimhäute sowie zur Blutstillung im oberen Aerodigestivtrakt stehen mechanochirurgische, elektrochirurgische und laserchirurgische Verfahren, Instrumente, Geräte und Systeme zur Verfügung. Die Argon-Plasma-Chirurgie (APC) ist in der HNO-Heilkunde für diese Indikationen ein neues Verfahren der Elektrochirurgie, bei welchem hochfrequenter elektrischer Strom (HF-Strom) durch ionisiertes und hierdurch elektrisch leitfähiges Argon (Argonplasma) kontaktfrei auf das zu behandelnde Gewebe appliziert wird. Eine besondere Eigenschaft der APC, welche für die oben genannten Indikationen vorteilhaft angewendet werden kann, ist die gut kontrollierbare und auch bei großflächiger Applikation auf maximal 3 mm begrenzte Tiefe der thermischen Gewebedestruktion, so daß eine Schädigung benachbarte bzw. submuköse Gewebe vermieden werden kann. Die ersten Resultate der APC zur Reduktion hyperplastischer Nasenmuscheln, Behandlung der hereditären hämorrhagischen Teleangiektasie (Morbus Osler) in der Nasenschleimhaut und der progredienten juvenilen Larynxpapillomatose zeigen deutliche Vorteile der APC im Vergleich zu den oben genannten Verfahren.
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  • 6
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Prädiktion der schwierigen Intubation ; HNO-Laserchirurgie ; Mallampati-Score ; Key words Prediction of difficult intubation ; ENT laser surgery ; Mallampati sign
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The Mallampati score (MS), later modified by Samsoon and Young, is a common method used to predict difficult intubation. We tested its predictive value in otolaryngologic (ENT) laser surgery. Methods: Ninety-one patients scheduled for elective ENT laser surgery had the modified MS noted prior to induction in the supine position, with the tongue fully protruded and phonating ”ah”; 22 patients were female, 69 male. The mean age was 54±15 (6–84) years, height 171±9 (130–190) cm, and weight 72±21 (20–99) kg. After a standard induction, the laryngoscopic view was graded according to Cormack and Lehane (C&L). An intubation was considered difficult if the C&L score was ≥3, i.e., no part of the glottis seen during laryngoscopy. The hypothesis tested was that a MS ≥3 (i.e., only the base of the uvula or nine of the uvula was seen) is predictive of difficult intubation in this group of patients. This chi-square test was used for calculation of significance. Results: All intubations were performed in less than three attempts, and no C&L score of 4 (i.e., not even the epiglottis seen during laryngoscopy) was observed; 10 patients had a C & L score ≥3, i.e., a difficult intubation according to our definition. Sixty-two patients had a MS ≤2; of these, 4 (=6%) were difficult to intubate. Twenty-nine patients had MS ≥3; of these, 6 (=21%) were difficult to intubate. This difference was significant (chi-square=4.1, P〈0,05). Conclusion: Difficult intubation was significantly more common in patients with MS ≥3. Low sensitivity (60%) and specificity (72%) limit the clinical value of this test, however.
    Notes: Zusammenfassung Der Mallampati-Score ist eine gebräuchliche Methode zur Vorhersage der schwierigen Intubation. Wir testeten seine Validität in der HNO-Laserchirurgie. Methoden: Bei 91 Patienten, die sich einem geplanten laserchirurgischen Eingriff in der HNO unterziehen mußten, wurde unmittelbar vor der Narkoseeinleitung der Mallampati-Score in der Modification nach Samsoon u. Young [18] ermittelt. Nach Narkoseeinleitung wurde die laryngoskopische Sicht nach Cormack u. Lehane [5] beurteilt. Es wurde untersucht, inwieweit ein Mallampati-Score ≥3 eine schwierige Intubation (d.h. einen Cormack u. Lehane-Grad ≥3) vorhersagt. Ergebnisse: 62 Patienten hatten einen Mallampati-Score ≤2. Von diesen hatten 4 (=6%) einen Cormack u. Lehane-Grad ≥3. 29 Patienten hatten einen Mallampati-Score ≥3. Von diesen hatten 6 (=21%) einen Cormack u. Lehane-Grad ≥3. Schlußfolgerung: Dieser Unterschied war signifikant im χ2-Test (p〈0,05). Patienten mit einem Mallampati-Score ≥3 waren also signifikant häufiger schwierig zu intubieren. Niedrige Sensitivität (60%) und Spezifität (72%) begrenzen jedoch den praktischen Wert des Tests.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 44 (1995), S. 613-623 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Endotracheale Intubation ; Ösophageale Tubusfehllage ; Kapnometrie ; Oesophageal-Detector-Device ; Rettungsdienst ; Key words Endotracheal intubation ; Oesophageal ET tube malposition ; Capnometry ; Oesophageal detector device ; Emergency medical system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Oesophageal malposition of an endotracheal tube is among the leading causes of anaesthesia incidents. While clinical manoeuvres for detection of tube malposition are unreliable, monitoring (i.e. capnography) can prevent such incidents. The problem is particularly important in prehospital care, where capnography is not (yet) widely available. We tested three devices used for differentiating oesophageal from endotracheal intubation: 1. Non-CO2dependent Oesophageal Detector Device (ODD) as described by Pollard and Wee, 2. Semi-quantitative chemical disposable capnometer EasyCAP (Nellcor), 3. Non-quantitative infrared miniaturised capnometer MiniCAP (MSA). Methods. 50 anaesthetised minipigs were intubated with a Magill tube. An identical additional tube was placed in the oesophagus. The cuffs of both tubes were inflated. Unexperienced personel (students, laborary technicians) were asked to determine the position of one of the tubes by using one of the devices according to the randomisation plan. The decision had to be taken within 30 s. Using the ODD, the proband first injected 100 ml air into the lung (or stomach) and then tried to aspirate the same volume. EasyCAP and MiniCAP were used according to manuals. Results. Each device was used 25 times with a tracheal tube and 25 times with an oesophageal tube. All tube position identifications were correct. When ventilating the oesophagus/stomach for capnometric control, regurgitation into the tube occurred six times (five times with the EasyCAP and once with the MiniCAP). In these cases, the decision was based on this occurrence and not on the display of the device. While using the ODD no regurgitation occurred. Conclusion. These devices are useful for preclinical practice. According to the literature and our experience, the ODD is superior for the initial control of tube position, especially in cardiac arrest. Capnometry is needed, however, for continuous control of ventilation.
    Notes: Zusammenfassung Die ösophageale Tubusfehllage zählt zu den häufigen Ursachen schwerer Narkosezwischenfälle. Sie ist heute durch Kapnographie zuverlässig entdeckbar, Zwischenfälle sind daher prinzipiell vermeidbar. Da die quantitative Kapnometrie im Rettungsdienst (noch) nicht verfügbar ist, bleibt das Problem der Erkennung einer ösophagealen Tubuslage im präklinischen Bereich weiterhin akut. Im Tierversuch wurden 3 Geräte getestet, die zur präklinischen Überprüfung der Tubuslage eingesetzt werden: 1. CO 2 -unabhängiges „Öesophageal Detector Device“ nach Pollard und Wee, 2. Semi-quantitatives chemisches Einmalkapnometer EasyCAP (Nellcor, Idstein), 3. Nicht-quantitatives Miniaturinfrarotkapnometer MiniCAP III (MSA, Pittsburgh). Möglichkeiten und Grenzen der Geräte sowie Literatur hierzu werden diskutiert.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 256 (1999), S. 10-15 
    ISSN: 1434-4726
    Keywords: Key words Hereditary hemorrhagic telangiectasia ; Epistaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) remains a challenge for all clinicians, as in about 80% of cases nasal bleeding is the first manifestation of this disease, which is characterized by a clinical triad of multiple telangiectasias, recurrent hemorrhages and familial occurrence. Although in the last few years there has been diagnostic and therapeutic progress, a cure for this rarely life-threatening but often burdening and handicapping disease is still not possible. We have reviewed head and neck presentations, diagnostic and therapeutic features, as well as new insights into the molecular genetics of the disease and local treatment now available.
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  • 9
    ISSN: 1434-4726
    Keywords: Key words Epidermal growth factor receptor ; Head and neck squamous cell carcinoma ; Cell proliferation ; Sialic acid ; Sialoglycan structures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Squamous cell carcinomas of the head and neck have been found to show a high expression of the receptor for epidermal growth factor (EGF). This overexpression of the receptor has been associated with malignant transformation of cells, although there is still debate as to what extent this receptor takes part in the proliferation of malignant cells and which function it fulfills. The factors which determine receptor-ligand interaction are also not clearly defined. That the extracellular domain of the EGF receptor carries carbohydrate or sialoglycan structures might be important for function of the receptor. Since tumor specific enzymes can possibly alter such structures, it was the aim of our study to investigate the role of these structures on the EGF receptor during the proliferation of head and neck carcinomas. We used the human laryngeal squamous carcinoma cell line HLaC 79 and altered, for the first time, specific glycan structures with sialidase α-2,3 and α-2,6, causing desialylation. Changes were also produced by endo-β-galactosidase and sialyltransferase. Findings were monitored by labeling with bromo-deoxyuridine. To determine receptor affinity, 125I-labeled EGF was employed. Results showed that both cell proliferation and receptor affinity depended on the level of sialylation of the receptor carbohydrate side chains. Desialylation led to a statistically significant reduction of tumor cell proliferation to 65 ± 33% (P 〈 0.01), while receptor affinity decreased to 70 ± 26% (P 〈 0.01).The importance of EGF receptor for the proliferation of malignant cells seems to depend on the level of sialylation of glycan structures on receptor protein. A release of enzymes by tumor cells may then produce auto-control of tumor proliferation on its own.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 257 (2000), S. 263-269 
    ISSN: 1434-4726
    Keywords: Key words Recurrent respiratory papillomatosis ; Pediatric laryngeal disease ; Human papilloma virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Juvenile-onset recurrent respiratory papillomatosis is a relatively uncommon disease that presents clinically with symptoms ranging from hoarseness to severe dyspnea. Human papilloma viruses type 6 and 11 are important in the etiology of the papillomata and are most probably transmitted from mother to child during childbirth. Although spontaneous remission is frequent, a rare fatal course because of pulmonary spread or malignant transformation has occurred. CO2 laser evaporation of papillomas and adjuvant drug therapy using lymphoblastoid α-interferon are the most common treatment modalities at present. However, several other treatment modalities have been tried with varying success. Recent advances in basic research and different therapeutic approaches are reviewed.
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