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  • 1
    Online Resource
    Online Resource
    Saint Louis :Elsevier Science & Technology,
    Keywords: Sex preselection. ; Sex of children, Parental preferences for. ; Electronic books.
    Description / Table of Contents: Sex Selection of Children explores the strategies used to control the sex of children, the conditions under which a couple would employ a given technique, and the technology to achieve their desired family composition. It also considers the social consequences of sex-selection techniques, the legal factors that might impinge on the use of such a technology, and the ethical considerations associated with its use. Organized into 10 chapters, this book begins with an overview of some of the more humorous past approaches to sex selection. It then discusses the effects of sex selection on fertility, sex selection by means of amniocentesis and selective abortion, and the theorized link between the timing of fertilization and the sex ratio of offspring. A chapter considers a decision-making model that describes the use of sex-selection techniques by couples who wish to have a specific number of children over their entire childbearing period, while another chapter analyzes the economics of sex preference and selection. The remaining chapters address the parental preferences about the sexes of their offspring in different societies, the legal aspects of prenatal sex selection, a moral policy for sex choice, and the ethics and public policy on sex choice. This book is a valuable resource for specialists involved in fields ranging from sociology and economics to biology, public health, law, and ethics.
    Type of Medium: Online Resource
    Pages: 1 online resource (277 pages)
    Edition: 1st ed.
    ISBN: 9780323158251
    Series Statement: Studies in Population
    DDC: 363.92
    Language: English
    Note: Front Cover -- Sex Selection of Children -- Copyright Page -- Table of Contents -- Contributors -- Foreword -- Preface -- Chapter 1. Sex Selection of Children: An Overview -- Historical Overview -- Current Research and an Overview of the Chapters -- Acknowledgments -- References -- Chapter 2. Measuring Sex Preferences and Their Effects on Fertility -- Introduction -- Potential Effects of Sex Selection -- Examples of the Potential Effects of Sex Selection -- A Decision-Making Model for Sex Preferences -- Considering Measures of Sex Preferences -- Unresolved Issues -- Acknowledgments -- References -- Chapter 3. Sex Selection through Amniocentesis and Selective Abortion -- Introduction -- Assumptions -- Birth Trial Probabilities -- Family Composition with No Sex Selection -- Sex Selection for Sequential Family Goals -- Sex Selection for Compositional Family Goals -- Discussion -- Summary -- Appendix -- References -- Chapter 4. Timing of Fertilization and the Sex Ratio of Offspring -- Introduction -- Earlier Direct Data -- More Recent Direct Data -- Other Mammalian Data -- Sex Ratio and Spontaneous Abortion -- Indirect Data -- Discussion -- Summary -- Acknowledgments -- Appendix -- References -- Chapter 5. Decision Making and Sex Selection with Biased Technologies -- Introduction -- The Decision-Making Model -- Discussion -- Acknowledgments -- References -- Chapter 6. The Economics of Sex Preference and Sex Selection -- Introduction -- Review of the Economic Approach -- A Model of Sequential Fertility -- Summary, Conclusions, and Suggestions for Further Research -- Acknowledgments -- References -- Chapter 7. Parental Sex Preferences and Sex Selection -- Introduction -- Patterns of Parental Sex Preferences -- Barriers to the Use of Sex Selection -- Impact of Sex Selection on Society and the Family -- References. , Chapter 8. Legal Aspects of Prenatal Sex Selection -- Introduction -- Conceptual Foundation for the Legal Analysis of Sex Selection -- Legal Issues -- Analysis of Current Law -- Legal Trends -- References -- Chapter 9. Toward a Moral Policy for Sex Choice -- Background -- Moral Dimensions of Sex Choice -- Policy for Sex Choice -- A Final Word -- References -- Chapter 10. Ethics and Public Policy: Should Sex Choice Be Discouraged? -- Introduction -- Moral Policy in Sexuality and Reproduction -- Consequences of Freedom with Fairness in Sex Choice -- Ethics, Public Policy, and the Future of Sex Choice -- Acknowledgments -- References -- Index -- Studies in Population.
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  • 2
    Keywords: Siderophiles Element. ; Electronic books.
    Description / Table of Contents: Reviews in Mineralogy & Geochemistry (RiMG) volumes contain concise advances in theoretical and/or applied mineralogy, crystallography, petrology, and geochemistry.
    Type of Medium: Online Resource
    Pages: 1 online resource (798 pages)
    Edition: 1st ed.
    ISBN: 9781501502095
    Series Statement: Reviews in Mineralogy and Geochemistry Series ; v.81
    DDC: 549/.112
    Language: English
    Note: Intro -- Table of Contents -- 1. Experimental Results on Fractionation of the Highly Siderophile Elements (HSE) at Variable Pressures and Temperatures during Planetary and Magmatic Differentiation -- INTRODUCTION AND SCOPE -- SOLID METAL -LIQUID METAL PARTITIONING -- EXPERIMENTAL APPROACH TO SOLID METAL-LIQUID METAL PARTITIONING (DSM/LM) -- HSE SOLUBILITY EXPERIMENTS: IMPLICATIONS FOR METAL-SILICATE PARTITIONING -- CALCULATING THE METAL-SILICATE MELT PARTITION COEFFICIENT FROM SOLUBILITY DATA -- Controls on the metal-silicate partition coefficient -- Metal inclusions in experiments and the analysis of contaminated phases -- Possible mechanisms of metal inclusion formation -- Experimental methods to measure HSE solubility and metal-silicate partitioning -- Summary of experimental data -- Application of results to core formation -- SILICATE AND OXIDE CONTROL ON HSE FRACTIONATION -- Experimental approach -- Spinel-melt partitioning of HSEs -- Silicate mineral-melt partitioning of HSEs -- Origin of the variation in partitioning -- Local PGM saturation during chromite growth -- MAGMATIC SULFIDE AND ASSOCIATED PHASES -- Experimental approach -- MSS-sulfide melt partitioning -- MSS-ISS-sulfide melt partitioning -- Sulfide melt-silicate melt and MSS-silicate melt partitioning -- Role of the chalcogens (Se, Te, As, Bi, Sb) -- SILICATE MELT-AQUEOUS LIQUID-VAPOR PARTITIONING -- Theoretical considerations -- Experimental methods -- The volatile/melt partitioning of Au -- The volatile/melt partitioning of PPGE -- The volatile/melt partitioning of IPGE and Re -- CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- 2. Analytical Methods for the Highly Siderophile Elements -- INTRODUCTION -- DATA QUALITY CONSIDERATIONS FOR THE HSE -- Sample heterogeneity and reproducibility -- MEASUREMENT PROCEDURES -- Chemical separation of HSE. , REFERENCE MATERIALS FOR HSE ANALYSIS -- APPENDIX -- REFERENCES -- 3. Nucleosynthetic Isotope Variations of Siderophile and Chalcophile Elements in the Solar System -- INTRODUCTION -- ORIGIN OF ELEMENTS: STELLAR NUCLEOSYNTHESIS -- Production of elements from He to Fe via hydrogen to silicon burning -- PRESOLAR GRAINS -- Types of presolar grains and their origin -- ISOTOPE ANOMALIES OF SIDEROPHILE AND CHALCOPHILE ELEMENTS IN BULK METEORITES -- Isotope anomalies of siderophile elements in bulk meteorites -- Isotope anomalies of chalcophile elements in bulk meteorites -- INTERNAL ISOTOPE ANOMALIES PRESENT IN CHONDRITES -- CAIs -- Acid leachates and residues -- Isotopic constraints on the s-process nucleosynthetic component -- ORIGIN OF PLANETARY SCALE ISOTOPE ANOMALIES IN METEORITES -- CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- 4. Highly Siderophile Elements in Earth, Mars, the Moon, and Asteroids -- INTRODUCTION -- MOTIVATION FOR STUDY AND BEHAVIOR OF THE HSE IN PLANETARY MATERIALS -- METHODS APPLIED TO INVESTIGATING SIDEROPHILE ELEMENTS IN PLANETARY MATERIALS -- HSE ABUNDANCES -- The rhenium-osmium, platinum-osmium and palladium-silver isotope systems -- Standardization in planetary studies -- Metal-sulfide-silicate modeling in chondritic systems -- Partial melt modeling of planetary mantles -- "Pristinity" of crustal and mantle samples -- Estimation of planetary mantle composition -- What do chondritic or nearly/broadly chondritic actually mean? -- PLANETARY MATERIALS -- Early Solar System materials -- Fragments of planetary cores and/or metal-rich melt pools -- Primitive achondrite meteorites -- Meteorites from differentiated asteroids -- Mars -- The Moon -- Terrestrial mantle composition -- Secondary alteration effects -- PLANETARY FORMATION PROCESSES -- Initial conditions and homogeneity of starting materials. , Partial melting and partitioning of the HSE -- Core crystallization -- 'Late-accretion' -- Alternative hypotheses for the abundances of the HSE in planetary mantles -- Magmatic processes -- Later impacts into planetary crusts -- COMPARATIVE PLANETOLOGY AND IMPLICATIONS FOR TERRESTRIAL FORMATION -- FUTURE DIRECTIONS -- ACKNOWLEDGEMENTS -- REFERENCES -- 5. Distribution and Processing of Highly Siderophile Elements in Cratonic Mantle Lithosphere -- INTRODUCTION -- THE CRATONIC MANTLE SAMPLE: PECULIARITIES, OPPORTUNITIES AND PITFALLS -- DATABASE -- MINERALOGY AND HSE HOSTS IN CRATONIC MANTLE PERIDOTITES -- ANALYTICAL TECHNIQUES FOR CRATONIC MANTLE PERIDOTITES -- Whole rocks and mineral separates -- Single-grain techniques -- UTILIZATION OF THE RE-OS ISOTOPE SYSTEM IN CRATONIC MANTLE STUDIES -- EFFECT OF MELT DEPLETION DURING CRATONIC LITHOSPHERE STABILIZATION ON SULFUR AND HSE SYSTEMATICS -- Sulfur and the persistence of sulfides -- Alloy saturation -- Chalcogens -- HSE PROCESSING DURING MANTLE METASOMATISM -- Modification during intraplate mantle metasomatism -- Modification during craton margin processes-subduction -- MODELLING OF PRIMARY VS. SECONDARY HSE SIGNATURES IN CRATONIC MANTLE -- HSE Concentrations of the Archean convecting mantle (ACM) -- Modelling Rationale -- Effects of partial melt extraction on HSE based on modelling -- Post-core formation, sluggish downward mixing of a late veneer -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- 6. Highly Siderophile Element and 187Os Signatures in Non-cratonic Basalt-hosted Peridotite Xenoliths: Unravelling the Origin and Evolution of the Post-Archean Lithospheric Mantle -- INTRODUCTION -- CONSTRAINING THE HSE AND 187Os/188Os ISOTOPIC COMPOSITION OF THE PRIMITIVE BULK SILICATE EARTH -- PETROLOGY AND LOCATION OF NON-CRATONIC PERIDOTITE XENOLITHS. , A BRIEF REVIEW OF HSE AND Os ISOTOPE ANALYTICAL METHODS AND HSE NORMALIZATION VALUES -- HOST MINERALS OF HIGHLY SIDEROPHILE ELEMENTS IN NON-CRATONIC PERIDOTITE XENOLITHS -- Nature of the host minerals -- Petrography of the base metal sulfides -- Origin of the base metal sulfides and platinum group minerals -- HIGHLY SIDEROPHILE ELEMENTS AND 187Os/188Os RESULTS FROM NON-CRATONIC PERIDOTITE XENOLITHS -- Summary of results from whole-rock studies -- Summary of results from base metal sulfides and other mineral phases -- Reconciling 187Os/188Os results from whole-rock and base metal sulfide analyses -- THE LIFE OF A XENOLITH, AS RECORDED IN HSE- AND Os-ISOTOPE SYSTEMATICS -- The HSE and 187Os composition of the Primitive Upper Mantle -- Whole-rock observations on samples representing melting residues -- Mineralogical control of HSE fractionation during partial melting -- Ancient melt-extraction events recorded by 187Os/188Os systematics -- Post-melting petrological history -- Syn- to post-eruptive processes -- CHRONOLOGICAL INTERPRETATION OF OS-ISOTOPIC DATA AND TECTONIC IMPLICATIONS -- Obtaining age information from Os isotopes of whole rocks -- Obtaining age information from Os isotopes of base metal sulfides -- Tectonic interpretation of Os model ages -- CONCLUSIONS -- ACKNOWLEDGEMENTS -- REFERENCES -- 7. Re-Pt-Os Isotopic and Highly Siderophile Element Behavior in Oceanic and Continental Mantle Tectonites -- INTRODUCTION -- BREVIA OF CONCEPTS, TERMINOLOGY, AND ANALYTICAL CAVEATS -- Re-Pt-Os parameters -- Normalization of concentration data -- Precision and accuracy of concentration data and analytical issues -- HIGHLY SIDEROPHILE ELEMENTS IN MANTLE TECTONITES FROM DIFFERENT GEODYNAMIC SETTINGS -- Summary of mantle tectonites and their geodynamic settings -- HSE IN ABYSSAL PERIDOTITES FROM SPREADING OCEANIC LITHOSPHERE. , HSE in mantle tectonites from continental extensional domains and continent-ocean transitions -- HSE in ophiolites that formed at fast spreading ridges with little or no influence from subduction processes -- High-temperature orogenic peridotites from convergent plate margin settings -- Highly siderophile elements in peridotites and melt-reacted lithologies of ophiolites influenced by convergent plate margin magmatism -- Highly siderophile elements in the mantle sections of ophiolites of uncertain origin -- DISCUSSION -- Influence of low-temperature alteration processes on the HSE in bulk rocks and minerals -- The influence of melt infiltration and partial melting on HSE abundances in mantle tectonites -- Summary-Mantle melting and mantle-magma interaction-different sides of the same coin -- Os isotopic heterogeneity in the mantle -- The role of recycled oceanic lithosphere in producing HSE and Os isotope signatures in magmas -- The relationship between abyssal peridotites and MORB: an osmium isotope perspective -- Interpretation of Re-Os model ages -- ACKNOWLEDGMENTS -- REFERENCES -- 8. Chalcophile and Siderophile Elements in Mantle Rocks: Trace Elements Controlled By Trace Minerals -- INTRODUCTION -- BACKGROUND -- Sulfides in the upper mantle and mantle rocks -- Abundance and phase control on chalcophile and siderophile elements in the fertile upper mantle -- Partial melting of the mantle: a BMS-removing and PGM producing petrogenetic process -- Chalcophile/siderophile element systematics in pyroxenites -- Low-pressure BMS dissolution in regional-scale open system melting of the sub-continental lithospheric mantle -- BMS precipitation associated with magma percolation/metasomatism -- Platinum-group minerals and magmatic percolation of the lithospheric mantle -- CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES. , 9. Petrogenesis of the Platinum-Group Minerals.
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  • 3
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    PANGAEA
    In:  Supplement to: Bennett, Neil R; Brenan, James M (2013): Controls on the solubility of rhenium in silicate melt: Implications for the osmium isotopic composition of Earth's mantle. Earth and Planetary Science Letters, 361, 320-332, https://doi.org/10.1016/j.epsl.2012.10.028
    Publication Date: 2023-01-13
    Description: The solubility of Re and Au in haplobasaltic melt has been investigated at 1673–2573 K, 0.1 MPa–2 GPa and IW-1 to +2.5, in both carbon-saturated and carbon-free systems. Results extend the existing, low pressure and temperature, dataset to more accurately predict the results of metal-silicate equilibrium at the base of a terrestrial magma ocean. Solubilities in run-product glasses were measured by laser ablation ICP-MS, which allows for the explicit assessment of contamination by metal inclusions. The Re and Au content of demonstrably contaminant-free glasses increases with temperature, and shows variation with oxygen fugacity (fO2) similar to previous results, although lower valence states for Re (1+, 2+) are suggested by the data. At 2 GPa, and Delta IW of +1.75 to +2, the metal-silicate partition coefficient for Re (DMet/Sil) is defined by the relation LogD[met/sil][Re] = 0.50(±0.022)*10**4/T(K)+3.73(±0.095) For metal-silicate equilibrium to endow Earth's mantle with the observed time-integrated chondritic Re/Os, (and hence 187Os/188Os), DMet/Sil for both elements must converge to a common value. Combined with previously measured DMet/Sil for Os, the estimated temperature at which this convergence occurs is 4500 (±900) K. At this temperature, however, the Re and Os content of the equilibrated silicate is ~100-fold too low to explain mantle abundances. In the same experiments, much lower Dmet/sil values have been determined for Au, and require the metal-silicate equilibration temperature to be 〈3200 K, as hotter conditions result in an excess of Au in the mantle. Thus, the large disparity in partitioning between Re or Os, and Au at core-forming temperatures argues against their mantle concentrations set solely by metal-silicate equilibrium at the base of a terrestrial magma ocean.
    Keywords: Aluminium oxide; Aluminium oxide, standard deviation; Barium oxide; Barium oxide, standard deviation; Calcium oxide; Calcium oxide, standard deviation; Electron microprobe (EMP); Elements, total; Gold; Gold, standard deviation; Iron; Iron, standard deviation; Iron oxide, FeO; Iron oxide, FeO, standard deviation; LA-ICP-MS, Laser-ablation inductively coupled plasma mass spectrometer; Magnesium oxide; Magnesium oxide, standard deviation; Nickel; Nickel, standard deviation; Rhenium; Rhenium, standard deviation; Sample code/label; Silicon dioxide; Silicon dioxide, standard deviation; Sodium oxide; Sodium oxide, standard deviation
    Type: Dataset
    Format: text/tab-separated-values, 499 data points
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  • 4
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 18 (1997), S. 463-483 
    ISSN: 0163-7525
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Notes: Abstract Poverty has been shown to negatively influence child health and development along a number of dimensions. For example, poverty-net of a variety of potentially confounding factors-is associated with increased neonatal and post-neonatal mortality rates, greater risk of injuries resulting from accidents or physical abuse/neglect, higher risk for asthma, and lower developmental scores in a range of tests at multiple ages. Despite the extensive literature available that addresses the relationship between poverty and child health and development, as yet there is no consensus on how poverty should be operationalized to reflect its dynamic nature. Perhaps more important is the lack of agreement on the set of controls that should be included in the modeling of this relationship in order to determine the "true" or net effect of poverty, independent of its cofactors. In this paper, we suggest a general model that should be adhered to when investigating the effects of poverty on children. We propose a standard set of controls and various measures of poverty that should be incorporated in any study, when possible.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 37 (1982), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To assess the differences in proteolytic activity of acute and chronic wound environments, wound fluids were collected from acute surgical wounds (22 samples) and chronic wounds (25 samples) of various etiologies, including mixed vessel disease ulcers, decubiti and diabetic foot ulcers. Matrix metalloproteinase (MMP) activity measured using the Azocoll assay was significantly elevated by 30 fold in chronic wounds (median 22.8 μg MMP Eq/ml) compared to acute wounds (median 0.76 μg MMP Eq/ml) (p 〈 0.001). The addition of the matrix metalloproteinase inhibitor Illomostat decreased the matrix metalloproteinase activity by approximately 90% in all samples, confirming that the majority of the activity measured was due to matrix metalloproteinases. Gelatin zymograms indicated predominantly elevated matrix metalloproteinase-9 with smaller elevations of matrix metalloproteinase-2. In addition tissue inhibitor of metalloproteinase-1 levels were analyzed in a small subset of acute and chronic wounds. When tissue inhibitor of metalloproteinase-1 levels were compared to protease levels there was an inverse correlation (p = 0.02, r = – 0.78). In vitro degradation of epidermal growth factor was measured by addition of 125I labelled epidermal growth factor to acute and chronic wound fluid samples. There was significantly higher degradation of epidermal growth factor in chronic wound fluid samples (mean 28.1%) compared to acute samples (mean 0.6%). This also correlated to the epidermal growth factor activity of these wound fluid samples (p 〈 0.001, r = 0.64). Additionally, the levels of proteases were assayed in wound fluid collected from 15 venous leg ulcers during a nonhealing and healing phase using a unique model of chronic wound healing in humans. Patients with nonhealing venous leg ulcers were admitted to the hospital for bed rest and wound fluid samples were collected on admission (nonhealing phase) and after 2 weeks (healing phase) when the ulcers had begun to heal as evidenced by a reduction in size (median 12%). These data showed that the elevated levels of matrix metalloproteinase activity decreased significantly as healing occurs in chronic leg ulcers (p 〈 0.01). This parallels the processes observed in normally healing acute wounds. This data also supports the case for the addition of protease inhibitors in chronic wounds in conjunction with any treatments using growth factors.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 8
    Publication Date: 2020-10-21
    Description: In order to use environmental models effectively for management and decision-making, it is vital to establish an appropriate level of confidence in their performance. This paper reviews techniques available across various fields for characterising the performance of environmental models with focus on numerical, graphical and qualitative methods. General classes of direct value comparison, coupling real and modelled values, preserving data patterns, indirect metrics based on parameter values, and data transformations are discussed. In practice environmental modelling requires the use and implementation of workflows that combine several methods, tailored to the model purpose and dependent upon the data and information available. A five-step procedure for performance evaluation of models is suggested, with the key elements including: (i) (re)assessment of the model's aim, scale and scope; (ii) characterisation of the data for calibration and testing; (iii) visual and other analysis to detect under- or non-modelled behaviour and to gain an overview of overall performance; (iv) selection of basic performance criteria; and (v) consideration of more advanced methods to handle problems such as systematic divergence between modelled and observed values. Highlights ► Numerical, graphical and qualitative methods for characterising performance of environmental models are reviewed. ► A structured, iterative workflow that combines several evaluation methods is suggested. ► Selection of methods must be tailored to the model scope and purpose, and quality of data and information available.
    Type: Article , PeerReviewed
    Format: text
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  • 9
    Publication Date: 2018-09-01
    Description: An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia, Published online: 31 August 2018; doi:10.1038/s41388-018-0474-y An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia
    Print ISSN: 0950-9232
    Topics: Medicine
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  • 10
    Publication Date: 2016-01-01
    Description: Nature Reviews Drug Discovery 15, 35 (2016). doi:10.1038/nrd4624 Authors: Namita A. Gandhi, Brandy L. Bennett, Neil M. H. Graham, Gianluca Pirozzi, Neil Stahl & George D. Yancopoulos Systemic type 2 inflammation encompassing T helper 2 (TH2)-type responses is emerging as a unifying feature of both classically defined allergic diseases, such as asthma, and a range of other inflammatory diseases. Rather than reducing inflammation with broad-acting immunosuppressants or narrowly targeting downstream
    Print ISSN: 1474-1776
    Electronic ISSN: 1474-1784
    Topics: Chemistry and Pharmacology , Medicine
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