Note: Front Cover -- Synaptic Constituents in Health and Disease -- Copyright Page -- PREFACE -- Table of Contents -- PART I: INTRODUCTORY LECTURE -- Chapter 1. Gene analysis and the diagnosis and treatment of inborn errors of metabolism -- PART II: SYMPOSIUM MOLECULAR ASPECTS OF THE STORAGE AND RELEASE OF NEUROTRANSMITTERS -- Chapter 2. The role of vesicles in cholinergic systems -- Chapter 3. Molecular organisation of catecholamine-storing organelles -- Chapter 4. Current knowledge of the storage and release of transmitter candidate amino acids and neuropeptides -- Chapter 5. Cyclic nucleotides, calcium ions and protein phosphorylation in neurotransmission -- POSTERS -- Chapter 6. Precursors of acetyl groups of acetylcholine and the role of acetyl-CoA in the control of acetylcholine synthesis -- Chapter 7. Effect of sialidase treatment upon choline uptake into a synaptosomal preparation of rat brain -- Chapter 8. Effects of acute choline administration on pharmacologically induced alterations in central cholinergic neurons -- Chapter 9. The effect of extraneuronal acetylcholine (ACh) on the rate of ACh release from the Auerbach plexus of guinea pig ileum -- Chapter 10. Serotonin-accumulating neurones in retina -- Chapter 11. Effect of maprotiline on serotonin in rat brain and in human platelets -- Chapter 12. Inhibition of serotonin uptake into spleen by a beta-adrenoceptor agonist: salbutamol -- Chapter 13. Adrenaline and noradrenaline release from 2 subpopulations of bovine chromaffin granules -- Chapter 14. Hydrophilic and amphiphilic forms of dopamine β-hydroxylase in early and mature stages of the bovine adrenomedullary granules -- Chapter 15. Isolation, sugar composition and immunological characterisation of glycoproteins of chromaffin granules. , Chapter 16. Effect of GABA on spontaneous and evoked release of 3H-NA from synaptosomes of rat brain mesodiencephalic region -- Chapter 17. Effect of bicuculline, γ'-aminobutyric acid and Ca2+ on the release of 3H-noradrenaline and 14C-'γ'-aminobutyric acid from slices of rat brain mesodiencephalic region -- Chapter 18. The effect of ethanol and acetaldehyde on GABA transport systems and its synthesis in rat brain synaptosomes -- Chapter 19. Pharmacology of GABA autoreceptors -- Chapter 20. [3H] L-glutamate and [3H]-glutamine uptake: an autoradiographic study in the developing rat cerebellum -- Chapter 21. Neurotransmitter amino acid uptake in human cerebral tissue in vitro -- Chapter 22. Release of endogenous amino acids from rabbit superior colliculus -- Chapter 23. Estimation of release and uptake of glutamate by hippocampal slices using modified microcup technique -- Chapter 24. Effects of adenosine derivates on the uptake and release of L-glutamate in rat brain synaptosomes -- Chapter 25. Calcium activation of synaptosomal glutaminase -- Chapter 26. Adenosine release from guinea-pig neocortex synaptosome beds -- Chapter 27. Oxidation of hypotaurine in brain and liver of developing mice -- Chapter 28. Effects of structural analogues and drugs on hypotaurine uptake in brain slices -- Chapter 29. Taurine uptake in developing retina -- Chapter 30. Taurine exit from cerebral cortex slices stimulated by sodium-deficient medium -- Chapter 31. Transmitter inactivation in primary cell cultures -- PART III: WORKSHOP CURRENT STATUS OF THE VESICULAR HYPOTHESIS FOR ACh RELEASE -- Chapter 32. Reversibility of transmitter release -- Chapter 33. The vesicular hypothesis examined by measuring acetylcholine with a fast freezing method -- Chapter 34. Incorporation of acetylcholine into Torpedo synaptic vesicles in vitro. , Chapter 35. De novo formation of synaptic vesicles in the superior cervical ganglion of cat -- Chapter 36. Are vesicles fusing with the presynaptic plasma membrane upon electrical stimulation of the electromotor synapses of Torpedo marmorata -- POSTERS -- Chapter 37. Nucleotide transport into isolated cholinergic synaptic vesicles -- Chapter 38. Inhibition of 3H-choline uptake into and 3H-acetylcholine release from brain tissue by tetanus and botulinum A toxin -- Chapter 39. The effect of the black widow spider venom on the free , bound and total acetylcholine content in mouse brain -- PART IV: WORKSHOP RECEPTOR PHARMACOLOGY -- Chapter 40. The use of antibodies in receptor studies -- Chapter 41. Current views on the structure of nicotinic acetylcholine receptors from different sources -- Chapter 42. Alpha adrenergic receptors in the vascular smooth muscle -- Chapter 43. Pharmacological characterization of GABA receptors -- POSTERS -- Chapter 44. Does the affinity of quaternary compounds depend on the presence of the ester group -- Chapter 45. Distribution and localisation of muscarinic receptors in the 24 hour post hatch chick brain -- Chapter 46. An immunofluorescence study of α-bungarotoxin receptors in the rat superior cervical ganglion -- Chapter 47. On the neurotoxin binding site of acetylcholine receptor protein -- Chapter 48. Mechanism of action of crotoxin on the postsynaptic membrane -- Chapter 49. Factors controlling the duration of postsynaptic response -- Chapter 50. Jontophoretically evoked responses during repetitive stimulation in the frog neuromuscular junction -- Chapter 51. Analysis of fluctuations produced by acetylcholine and its analogues in neurones of mollusc Limnaea stagnalis -- Chapter 52. Effect of β-carbolines on brain cholinergic system. , Chapter 53. Monoamine neurotransmitters and scopolamine treatment-neurochemical studies -- Chapter 54. Effect of cholinergic and adrenergic stimulation on calcium efflux from glioma cultured cells -- Chapter 55. Interactions between cholinergic and adrenergic systems in the rabbit hypothalamus -- Chapter 56. Changes in alpha2 - adrenoreceptor density after chronic treatment with imipramine -- Chapter 57. Action of imipramine on noradrenaline uptake, noradrenergic receptors and adenylate cyclase -- Chapter 58. The effect of propranolol on the porphyrin synthesis of chick embryo brain tissue culture -- Chapter 59. On effects of Ca-binding proteins and biogenic amines -- Chapter 60. Mg, Ca-ATPase of synaptic membranes and biogenic amines -- Chapter 61. Biomolecular information in adrenergic ligands -- Chapter 62. Central dopamine receptor ligand topography -- Chapter 63. Dopamine and synthesis of hippocampal glycoproteins -- Chapter 64. Is there a relation between the striatal dopamine-susceptible Na, K-ATPase activity and dopamine receptors ? -- Chapter 65. Development of supersensitive state on dopaminergic receptors after the acute administration of neuroleptic drug isofloxythepin -- Chapter 66. Changes in striatal and mesolimbic dopamine receptors after single in vivo administration of morphine -- Chapter 67. Effects of drugs affecting serotonergic system on activities of central dopaminergic and serotonergic systems in r a t s -- Chapter 68. The effect of 5-hydroxytryptamine on aggressive behaviour and convulsions caused by cholinomimetics and anticholinesterases in conscious cats -- Chapter 69. Metabolic changes in dentate gyrus following denervation of the perforant path -- Chapter 70. Glutamate decarboxylase in the rat thyroid gland -- Chapter 71. GABA binding processes in rat brain. , Chapter 72. Regulation of GABA receptor binding to synaptic plasma membrane of rat cerebral cortex -- Chapter 73. Effect of GABOB on the acid mucopolysaccharides in the rat brain regions -- Chapter 74. Primary cultures of astrocytes and GABA -- Chapter 75. Influence of capsaicin treatment on neurotransmitter binding to spinal cord membranes of the rat -- Chapter 76. The effect of litoralon/gamma-L-glutamyl-taurine/on the bovine retinal phospholipids -- Chapter 77. In vivo effects of some neurotransmitters on rat cerebellar cyclic GMP levels -- Chapter 78. cGMP elevation and 45Ca2+ movement due to agents affecting ion channels -- PART V: SYMPOSIUM TRANS-SYNAPTIC STRUCTURES AND SPECIFIC PROTEINS -- Chapter 79. Occurrence and postulated functions of trans - synaptic structures -- Chapter 80. Specific synaptic proteins -- Chapter 81. The molecular organization of cholinergic proteins at the synapse -- Chapter 82. Signification of glial fibrillary acidic protein in pathology -- POSTERS -- Chapter 83. Structure and cytochemistry of synaptic cleft -- Chapter 84. Scanning and transmission electron microscopy and ultracytochemistry of cerebellar mossy glomerular synapses -- Chapter 85. Purification of the synaptic membrane glycoprotein D2 from rat brain -- Chapter 86. Kinetics of rat hippocampal glycoproteins as demonstrated by page-autoradiography after intraventricular application of tritium-labelled L-fucose and N-acetyl-D-glucosamine -- Chapter 87. Synaptic proteins in retinal ganglion cells -- Chapter 88. Prebasic protein of myelin isolated from human brain -- Chapter 89. Radioimmunoassay of myelin basic protein in spinal fluid and in brain tissue -- Chapter 90. Differential sensitivity among discrete brain areas following inhalation of an organic solvent. , Chapter 91. Evidence for the formation of a tight complex between S-100 protein and its specific binding sites in synaptosomal particulate fractions.