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  • 1
    Publication Date: 2022-05-25
    Description: Author Posting. © American Geophysical Union, 2004. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 109 (2004): C08016, doi:10.1029/2003JC002024.
    Description: Mixed layer depth (MLD) over the north Indian Ocean (30°S to 30°N and 40°E to 110°E) is computed using the simple one-dimensional model of Price et al. [1986] forced by satellite-derived parameters (winds and chlorophyll). Seasonal chlorophyll observations obtained from the Coastal Zone Color Scanner allow us to examine how biology interacts with physics in the upper ocean by changing the absorption of light and thus the heating by penetrative solar radiation, an effect we refer to as biological heating. Our analysis focus mainly on two aspects: the importance of varying biology in the model simulations relative to runs with constant biology and secondly, the contribution of biology to the seasonal variability of the MLD. The model results are compared with observations from a surface mooring deployed for 1 year (October 1994 to October 1995) in the central Arabian Sea and also with available conductivity-temperature-depth (CTD) observations from the Arabian Sea during the period 1994–1995. The effect of biological heating on the upper ocean thermal structure in central Arabian Sea is found to be greatest in August. In other months it is either the wind, which is the controlling factor in mixed layer variations, or the density variations due to winter cooling and internal dynamics. A large number of CTD observations collected under the Joint Global Ocean Flux study and World Ocean Circulation Experiment have been used to validate model results. We find an overall improvement by approximately 2–3 m in root-mean-square error in MLD estimates when seasonally varying chlorophyll observations are used in the model.
    Description: U.S. Navy Office of Naval Research (grant N00014-94-1-0161)
    Keywords: Biological heating ; ERS scatterometer wind ; Extinction depth ; 1-D mixed layer model ; Mixed layer depth variations
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 26 (1993), S. 5954-5958 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0495
    Keywords: Key words Interstitial water geochemistry ; Nutrients ; Early diagenesis ; Tropical estuaries ; Southwest coast of India
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  The concentrations of N, P and Fe in surface sediments and interstitial and overlying (bottom and surface) waters of the Ashtamudi estuary located in the southwest coast of India are reported along with the various chemical species of N (NO2–N, NO3–N, NH3–N and total N) and P (organic P, inorganic P and total P) in interstitial and overlying waters and discussed in terms of the physico-chemical environment of the system. The interstitial water exhibits higher salinity values compared to bottom and surface waters, indicating the coupled effects of salt-wedge phenomena and gravitational convection of more saline-denser marine water downward through surface sediments. N, P and Fe as well as their chemical forms are enriched in the interstitial water compared to bottom and surface waters. However, the dissolved oxygen (DO) shows an opposite trend. The marked enrichment of NH3–N in the interstitial water and its marginal presence in bottom and surface waters, together with the substantial decrease in the DO concentrations of bottom water and consequent increase in the concentrations of NO2–N and NO3–N in interstitial and bottom waters, points to the nitrification process operating in the sediment-water interface of the Ashtamudi estuary. The enrichment of total N, P and Fe in the interstitial water compared to the overlying counterparts and the positive correlation of sediment N, P and Fe with mud contents as well as organic carbon indicate that these elements are liberated during the early diagenetic decomposition of organic matter trapped in estuarine muds.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2013-11-15
    Description: Recent guidance on drug-drug interaction (DDI) testing recommends evaluation of circulating metabolites. However, there is little consensus on how to quantitatively predict and/or assess the risk of in vivo DDIs by multiple time-dependent inhibitors (TDIs) including metabolites from in vitro data. Fluoxetine was chosen as the model drug to evaluate the role of TDI metabolites in DDI prediction because it is a TDI of both CYP3A4 and CYP2C19 with a circulating N-dealkylated inhibitory metabolite, norfluoxetine. In pooled human liver microsomes, both enantiomers of fluoxetine and norfluoxetine were TDIs of CYP2C19, ( S )-norfluoxetine was the most potent inhibitor with time-dependent inhibition affinity constant ( K I ) of 7 μ M, and apparent maximum time-dependent inhibition rate ( k inact,app ) of 0.059 min –1 . Only ( S )-fluoxetine and ( R )-norfluoxetine were TDIs of CYP3A4, with ( R )-norfluoxetine being the most potent ( K I = 8 μ M, and k inact,app = 0.011 min –1 ). Based on in-vitro - to-in-vivo predictions, ( S )-norfluoxetine plays the most important role in in vivo CYP2C19 DDIs, whereas ( R )-norfluoxetine is most important in CYP3A4 DDIs. Comparison of two multiple TDI prediction models demonstrated significant differences between them in in-vitro-to-in-vitro predictions but not in in-vitro-to-in-vivo predictions. Inclusion of all four inhibitors predicted an in vivo decrease in CYP2C19 (95%) and CYP3A4 (60–62%) activity. The results of this study suggest that adequate worst-case risk assessment for in vivo DDIs by multiple TDI systems can be achieved by incorporating time-dependent inhibition by both parent and metabolite via simple addition of the in vivo time-dependent inhibition rate/cytochrome P450 degradation rate constant ( / k deg ) values, but quantitative DDI predictions will require a more thorough understanding of TDI mechanisms.
    Print ISSN: 0090-9556
    Electronic ISSN: 1521-009X
    Topics: Chemistry and Pharmacology , Medicine
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