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  • 1
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 256 (1995), S. S212 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pain on injection and quality of induction were compared in 74 children (5–12 years) randomly assigned to receive either 5 mg·kg−1 of cold propofol (group A), 5 mg·kg−1 of cold propofol mixed with lignocaine 1% (group B) or 5 mg·kg−1 of propofol at room temperature (22–23°C) mixed with lignocaine 1% (group C). The group receiving cold propofol had to be stopped due to a very high incidence of pain (70%). The incidence of pain on injection was 3% in group B and 17% in group C (not significant). Quality of induction and side-effects were similar in the two groups.
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 46 (1991), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 51 (1996), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1238
    Keywords: Sedation ; Propofol ; Midazolam ; Intensive care unit ; Surgical ; Mental disorders ; Sleep disorders ; Hospital Anxiety and Depression Scale
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To assess and compare the impact of overnight sedation with midazolam or propofol on anxiety and depression levels, as well as sleep quality, in non-intubated patients in intensive care. Design Open, comparative, prospective, randomised study. Setting Surgical intensive care unit (ICU) in a university hospital. Patients 40 conscious patients expected to stay in the ICU for at least 5 days who were admitted following trauma or elective orthopaedic, thopaedic, thoracic or abdominal surgery. Measurements and results Evaluation of a self-assessment scale (Hospital Anxiety and Depression Scale, HAD) on the day following the 1st, 3rd and 5th night of sedation with either midazolam or propofol. Heart rate, pulse oximetry and blood gases were monitored. Eight patients were excluded from the analysis. The level of anxiety was severe (HAD〉10) in 31% of the patients receiving midazolam and in 26% (p=0.1) receiving propofol after the first night of sedation, with no significant improvement over the next few days. The levels of depression remained high (〉10) in 54% of patients receiving midazolam, and in 16% of the patients receiving propofol (p=0.15). Sleep quality tended to improve during the study in the two groups. Conclusions These data show that half of the patients in the ICU experienced high levels of anxiety and depression during the first 5 postoperative or post-trauma days in the ICU. The beneficial effects of sedation on sleep quality were comparable for midazolam and propofol, regardless of a lack of improvement in anxiety and depression. However, an improved quality of sleep could help to re-establish a physiological night and day rhythm.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 20 (1994), S. 611-612 
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Arthroskopie 12 (1999), S. 237-245 
    ISSN: 1434-3924
    Keywords: Schlüsselwörter Patella baja ; Arthrofibrose ; Complex regional pain syndrome ; Adhäsiolyse ; Tuberositas-tibiae-Osteotomie ; Regionale Sympathikusblockade ; Key words Patella baja ; Arthrofibrosis ; Complex regional pain syndrome ; Adhesiolysis ; Tibial tubercle osteotomy ; Regional sympathetic blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Patella baja is most frequently seen in the postoperative knee. Quadriceps muscle dysfunction secondary to pain or joint effusion can initiate the process. The descend of the patella is still reversible at this stage and can be treated successfully by physiotherapy. Aggressive range of motion exercises, if necessary starting with closed manipulation under anesthesia, and stimulation of the extensor mechanism are mandatory. If the condition is not recognized and appropriately treated, the prognosis is poor because of adaptive changes. Fibrosis of the Hoffa fat pad, adherence of the patellar tendon to the anterior tibia, periarticular and peripatellar contracture, adaptive shortening of the patellar tendon, and intraarticular adherences cause devastating joint stiffness. Open arthrotomy to achieve lateral or medial retinacular release and débridement of all adhesions, excision of the fibrotic tissue between the distal pole of the patella and the anterior tibial plateau, including the scarred fat pad, is our treatment of choice. If the patellar tendon is too short and approriate flexion can not be achieved intraoperatively, a proximal transposition of the tibial tubercle osteotomy is performed. Reflex sympathetic dystrophy (complex regional pain syndrome) has to be ruled out if motion is limited postoperatively. This condition leads extremely rapidly to extensive shortening of the patellar tendon and requires early recognition and treatment. Repetitive regional sympathetic blockade after onset of the first clinical signs may prevent development of dystrophy. Surgery is contraindicated in the acute stage. Patellectomy and tubular reinforcement of the remaining patellar tendon may then enable reasonable postoperative range of motion and relief from patellofemoral pain. Congenital patella baja is most often associated with other skeletal malformations and does usually not require treatment.
    Notes: Die Patella baja kann im Rahmen einer postoperativen oder posttraumatischen Arthrofibrose des Kniegelenks auftreten. Am Anfang steht meist eine durch Schmerz oder Gelenkerguss bedingte Quadrizepsschwäche. Bei entsprechender Früherkennung und konsequenter physiotherapeutischer Behandlung mit Stimulation der Quadrizepsmuskulatur, allenfalls nach vorangegangener Mobilisation in Narkose bei bestehender Flexionshemmung, ist der Patellatiefstand zu diesem Zeitpunkt noch reversibel. Falls bereits eine Fibrose des Hoffa-Fettkörpers, Verklebungen der Patellarsehnenrückfläche mit dem vorderen Tibiakopf und intraartikuläre sowie periartikuläre Narbenbildungen eingetreten sind, ist die Prognose wesentlich schlechter. Ein arthroskopisches Débridement kann genügen, wenn die Narbenbildung vorwiegend intraartikulär besteht. Falls eine Patellarsehnenverkürzung vorliegt, bevorzugen wir die offene Arthrolyse, um den gesamten Hoffa-Fettkörper zu exzidieren und die Patellarsehnenrückfläche von der proximalen Tibia zu lösen. Bei struktureller Verkürzung der Patellarsehne kann die Flexionshemmung des Kniegelenks oft nur mit einer proximalen Transposition der Tuberositas tibiae korrigiert werden. Die ausgeprägteste Patellarsehnenverkürzung wird bei der Algodystrophie (complex regional pain syndrome) beobachtet. Ein operativer Eingriff ist bei diesem Krankheitsbild im floriden Stadium kontraindiziert. Die regionale Sympathikusblockade stellt die Behandlung der Wahl dar, die nur bei frühzeitigem und konsequentem Einsatz das dystrophische Stadium verhindern kann. Nach Abheilung des entzündlichen Zustandsbilds kann mit einer Patellektomie und tubulären Verstärkung der verbleibenden Patellarsehne eine ansprechende Flexion erreicht und die patellofemoralen Schmerzen gelindert werden. Die kongenitale Patella baja ist meist mit anderen Skelettmissbildungen assoziiert und bedarf in der Regel keiner Behandlung.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 47 (1998), S. 918-924 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Propofol ; Antiemetische Wirkung ; Dopaminerges System ; Serotoninerges System ; Key words Propofol ; Antiemetic actions ; Dopaminergic system ; Serotoninergic system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Propofol is known to possess direct antiemetic effects. Its use for induction and maintenance of anaesthesia has been shown to be associated with a lower incidence of postoperative nausea and vomiting (PONV) when compared to any other anaesthetic drug or technique. However, its mechanism of action in this context is still not well understood. In this article, the best ways to take advantage of propofol’s antiemetic properties are emphasized. The possible effects of propofol on the cerebral cortex, its interactions with the dopaminergic and the serotoninergic systems are evaluated by the known clinical and basic science results. Finally, the advantages and disadvantages of using propofol to decrease the incidence of PONV in clinical practice are discussed.
    Notes: Zusammenfassung Die direkte antiemetische Wirkung von Propofol ist bereits bekannt. Die Kombinationen von Anästhesieeinleitung und Anästhesieunterhalt mit Propofol ergeben bei Total intravenöser Anästhesie (TIVA) eine, im Vergleich zu anderen Anästhesiemedikamenten oder -techniken, verminderte Inzidenz von postoperativer Übelkeit und Erbrechen (PONV). Der diesbezügliche Wirkungsmechanismus ist nicht ganz geklärt. In diesem Artikel wird gezeigt, wie der Vorteil der antiemetischen Wirkung von Propofol am besten ausgenützt werden kann. Die mögliche Wirkung von Propofol auf den Cortex cerebri und seine Wechselwirkung mit dem dopaminergen und dem serotoninergen System werden mittels Ergebnissen aus der klinischen und der Grundlagenforschung diskutiert. Schließlich werden die Vor- und Nachteile von Propofol bezüglich der Inzidenzverminderung von PONV in der klinischen Praxis besprochen.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 20 (1994), S. 148-149 
    ISSN: 1432-1238
    Keywords: Propofol ; Status epilepticus ; Drug-induced coma ; EEG monitoring ; Intensive care unit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Status epilepticus is one of the most frequent neurological emergencies in the intensive care unit. Standard treatment includes intravenous barbiturates, benzodiazepines and phenytoin. However, drug coma is sometimes necessary to control refractory status epilepticus. We report such a case, successfully treated by intravenous propofol coma to EEG burst suppression.
    Type of Medium: Electronic Resource
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