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  • 1
    Electronic Resource
    Electronic Resource
    An antidiabetic thiazolidinedione induces eccentric cardiac hypertrophy by cardiac volume overload in rats (2004)
    Oxford, UK : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 31 (2004), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. To assess the involvement of volume overload in the development of cardiac hypertrophy during treatment with an antidiabetic thiazolidinedione, changes in cardiac anatomy and parameters of cardiac volume overload were evaluated in female Sprague-Dawley rats treated with the thiazolidinedione derivative T-174.2. Two week administration of T-174 (13 and 114 mg/kg per day) increased absolute and relative heart weights by 11–24%, demonstrating the development of cardiac hypertrophy. There was no evidence of oedema in hearts from treated rats.3. Both plasma and blood volumes were increased in T-174-treated rats without any changes in systolic blood pressure and heart rate, whereas haematocrit was decreased. In accordance with the existence of volume overload, both left ventricular end-diastolic pressure and right atrial pressure were increased. Morphometric analysis of hearts revealed that T-174 induced eccentric heart hypertrophy, as characterized by a small increase in wall thickness and a large increase in the chamber volume, which is characteristic of volume overload. Volume overload is suggested as the possible trigger mechanism because blood volume expansion preceded cardiac hypertrophy and there was a high correlation between heart weight and blood volume.4. T-174-treated streptozotocin-induced diabetic rats also exhibited blood volume expansion and cardiac hypertrophy.5. These findings suggest that cardiac volume overload is induced by plasma volume expansion and contributes to the development of eccentric cardiac hypertrophy during treatment with antidiabetic thiazolidinediones. Although thiazolidinediones are insulin-sensitizing agents, these cardiac effects are likely to be mediated independently of insulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.2004.03954.x
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  • 2
    Electronic Resource
    Electronic Resource
    NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy (1998)
    Springer
    Acta neuropathologica 96 (1998), S. 439-444 
    Details
    ISSN: 1432-0533
    Keywords: Key words NACP ; Synuclein ; Multiple system ; atrophy ; Neuronal cytoplasmic inclusions ; Glial ; cytoplasmic inclusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid β component of Alzheimer’s disease amyloid precursor protein (NACP/α-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050917
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  • 3
    Electronic Resource
    Electronic Resource
    Treatment of hepatocellular carcinoma utilizing lymphokine-activated killer cells and interleukin-2 (1989)
    Springer
    Cancer chemotherapy and pharmacology 23 (1989), S. S45 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper is a report on adoptive immunotherapy involving consecutive injections of recombinant interleukin-2 and lymphokine-activated killer (LAK) cells in the treatment of hepatocellular carcinoma. Peripheral blood lymphocytes, obtained by leukopheresis, acted as the activated killer cells with a co culture of recombinant interleukin-2 in the culture system. After 4 days, the activated killer cells were returned into the patients' bodies intra-arterially and intravenously. No complete remissions or partial remissions have resulted, although five of the seven patients showed a significant decrease in their serum α-fetoprotein levels after treatment. In addition, one case showed a patent portal truncus while another indicated the appearance of central necrosis on the computerized tomograph scan. Although the period of observation was short, there were no recurrences after the combination therapy of tumor resection and LAK adoptive immunotherapy. It might be difficult to treat hepatocellular carcinoma with adoptive immunotherapy alone, but there is some possibility of conducting therapy for hepatocellular carcinoma after removing the majority of the tumor cells by surgical resection and transcatheter arterial embolization therapy. This conclusion indicates, at least theoretically, that adoptive immunotherapy will be suitable in the treatment of hepatocellular carcinoma as one of the combination therapies with the two major forms of treatment mentioned above.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00647239
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  • 4
    Electronic Resource
    Electronic Resource
    Component-specific effects of physostigmine on the cat visual evoked potential (1993)
    Springer
    Experimental brain research 95 (1993), S. 271-276 
    Details
    ISSN: 1432-1106
    Keywords: Acetylcholine ; Physostigmine ; Visualevoked potential ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pattern visual evoked potentials (VEPs) were recorded from the pial surface of the cat primary visual cortex prior to and following the intravenous administration of physostigmine, an agent which blocks the enzyme responsible for the breakdown of synaptically released acetylcholine. The control VEP was composed of a small initial positive deflection (P1), a subsequent large negative wave (N1) and a second large positive wave (P2). Following physostigmine, the amplitude of P1-N1 was diminished whereas that of N1-P2 increased. These effects were long lasting and were blocked by prior treatment with scopolamine, a result consistent with mediation by a muscarinic cholinergic pathway. Waveform subtraction revealed that the physostigmine-sensitive component had a slow, negative polarity waveform while the physostigmine-insensitive component was also slow, but positive in polarity. The fundamental nature of these components remains to be assessed. Nevertheless, the results indicate that waveforms of different polarity combine algebraically to yield the conventional VEP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229785
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  • 5
    Electronic Resource
    Electronic Resource
    The effects of physostigmine on the response characteristics of the cat visual evoked potential (1993)
    Springer
    Documenta ophthalmologica 84 (1993), S. 257-265 
    Details
    ISSN: 1573-2622
    Keywords: Acetylcholine ; Cat ; Physostigmine ; Scopolamine ; Visual cortex ; Visual evoked potential (VEP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Steady—state pattern visual evoked potentials were recorded from the surface of the cat primary visual cortex before and after the intravenous administration of physostigmine, an agent that blocks the enzyme responsible for the breakdown of synaptically released acetylcholine. Under pentobarbital anesthesia, physostigmine increased the amplitude and changed the phase of the second response harmonic of the visual evoked potential, whereas the amplitude and phase of the fourth harmonic were not affected. These effects persisted for 15 to 45 minutes and were blocked by prior treatment with scopolamine or atropine. In addition, scopolamine or atropine administered 5 to 10 minutes after physostigmine returned the visual evoked potential to the baseline state. In comparison, when nitrous oxide was used, physostigmine caused a marked reduction in visual evoked potential amplitude, an effect that was reversed by subsequent atropine. These results indicate that the cholinergic system influences the visual evoked potential via a muscarinic pathway and that this influence is strongly affected by the anesthetic regimen used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01203658
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  • 6
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    Corrigendum: Discovery of Atg5/Atg7-independent alternative macroautophagy (2016)
    Nature Publishing Group (NPG)
    In: Nature
    Details
    Publication Date: 2016-05-05
    Description: Corrigendum: Discovery of Atg5/Atg7-independent alternative macroautophagy Nature 533, 7601 (2016). doi:10.1038/nature16538 Authors: Yuya Nishida, Satoko Arakawa, Kenji Fujitani, Hirofumi Yamaguchi, Takeshi Mizuta, Toku Kanaseki, Masaaki Komatsu, Kinya Otsu, Yoshihide Tsujimoto & Shigeomi Shimizu Nature461, 654–658 (2009); doi:10.1038/nature08455In Supplementary Fig. 19a of this Letter, the ‘no treatment’ panels for Stx7 contain incorrect data, owing to an error in image placement during figure preparation. The Supplementary Information to this Corrigendum
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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