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  • 1
    ISSN: 1432-1459
    Keywords: Amyotrophic lateral sclerosis ; Survival ; Mortality Gompertzian analysis ; France
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gompertzian analysis is a statistical technique which has been successfully applied to the analysis of amyotrophic lateral sclerosis (ALS) mortality in England and Wales, Japan and the United States. This paper analyses the consistent trend of rising ALS mortality in France over the years 1968–1990, a period during which crude mortality rose from 400 deaths in 1968 to 950 deaths in 1990. The findings indicate that age-specific mortality rates have risen at ages older than 54 years for men and 53 years for women and decreased slightly at younger ages. The evolving ALS mortality pattern is attributable to changing inter-disease competition resulting from the increased life expectancy of the French population, rather than to changing environmental aetiopathogenic factors or to substantial artefact effects.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-8491
    Keywords: Ageing ; Cognitive functioning ; Hypertension ; Psychotropic drug use
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the preparatory phase of a randomised controlled trial data were collected to assess the magnitude of changes on cognitive functions in 1628 volunteers (age range 45–75 years) that were recruited from general practitioners' patient population. Subjects were administered a short neuropsychological battery of tests including three paper-and-pencil tests, which assessed immediate recall, delayed memory, and attention. Being on antihypertensive medication was associated with low results for all three tests in every age group, and in all strata according to blood pressure levels. Psychotropic drug use was correlated with low results for all three tests. Differences between psychotropic drug users and nonusers increased with age. Antihypertensive treatment and psychotropic drug use seem to be important to consider in longitudinal studies of cognitive decline in aging.
    Type of Medium: Electronic Resource
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