ISSN:
1573-7225
Schlagwort(e):
ascorbic acid
;
breast neoplasms
;
prospective studies
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Objectives:To investigate the association between prediagnostic plasma ascorbic acid concentrations and subsequent breast cancer risk in a nested case–control study. Methods:Female volunteer residents of Washington County, MD, donated 14,625 non-fasting blood samples in 1989. Incident breast cancer cases (n = 115) and controls (n = 115) were matched by age, menopausal status at donation, and date and hour of blood donation. Results:Median ascorbic acid concentrations were similar between cases and controls (1.44 mg/dl vs. 1.39 mg/dl, p = 0.78). There was no evidence for a dose–response relationship between higher plasma ascorbic acid concentrations and breast cancer risk [highest vs. lowest fifths: ORadjusted = 0.90, p trend = 0.98). Conclusions:Findings from this prospective study do not suggest a protective association between prediagnostic plasma ascorbic acid concentrations and breast cancer risk in the subsequent 5years of follow-up.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1008983718924
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