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  • 1
    Electronic Resource
    Electronic Resource
    Cephalopod limestone deposition on a shallow pelagic ridge: the Tafilalt Platform (upper Devonian, eastern Anti-Atlas, Morocco) (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 31 (1984), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: As a result of early Variscan tectonic movements and of differential subsidence, a platform and basin topography was created along the northern margin of the Sahara Craton during the late Devonian. In the Moroccan Anti-Atlas Mountains, the Tafilalt Platform is an approximately N-S running ridge which developed since the late Middle Devonian. It separated a slowly subsiding shallow basin in the east (Tafilalt Basin) from a rapidly subsiding furrow in the west (Mader Basin). Platform deposits are characterized by highly reduced thicknesses, shallow subtidal to supratidal deposits in the late Frasnian and by unconformities at the Lower/Upper Frasnian and the Frasnian/Famennian boundaries. After a local transgression over emergent areas in the north, water depth probably never reached more than several tens to about 100 m in the lower Famennian. Cephalopod limestones of this age, deposited on the platform, represent a very diverse facies pattern comprising quartz-rich brachiopod coquinas, crinoidal limestones, thick-bedded cephalopod limestones and nodular limestones. Sedimentation rates ranged from 1 to 5 mm/ 1000 yr. In the late Famennian more uniform marl and nodular limestone facies suggest slightly deeper environments. Platform margins are characterized by higher rates of subsidence, debris flow deposits and slump structures. In the relatively shallow Tafilalt Basin, marls with intercalated nodular limestones were deposited. In the Mader Basin, sandy and calcareous turbidites suggest deeper water conditions in the late Devonian. During the Strunian/Tournaisian the whole area was overwhelmed by a thick deltaic sequence. The general facies distribution is in agreement with depositional models of other Upper Devonian and Lower Carboniferous cephalopod limestones in the European Variscan orogenic belts. In all these cases, condensed cephalopod limestones occupy a distinct palaeogeographic position in predictable facies sequences that reflect pre-orogenic phases in the Variscan geodynamic cycle. Moreover, close parallels exist with condensed sequences in the Triassic and Jurassic that occur in a very similar position within the Alpine orogenic cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3091.1984.tb01226.x
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  • 2
    Electronic Resource
    Electronic Resource
    De-differentiated chondrosarcoma is not a ‘de-differentiated’ chondrosarcoma (1998)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 33 (1998), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims: De-differentiated chondrosarcoma is characterized by the presence of two distinct chondroid and nonchondroid tumour portions. The aim of our study was to investigate the distribution of extracellular matrix components in this tumour entity and thus to shed light on its histogenetic origin.〈section xml:id="abs1-1"〉〈title type="main"〉Methods and resultsHistochemical and immunohistochemical analyses were performed for collagen subtypes I, II, III and VI and cartilage proteoglycans in three samples of de-differentiated as well as conventional chondrosarcomas (various grades). In the chondroid tumour areas of de-differentiated chondrosarcoma, typical cartilage matrix components could be detected similar to chondroid areas of grade 1 and 2 conventional chondrosarcomas. In contrast, the tumour matrix of the nonchondroid portions of de-differentiated chondrosarcomas contained matrix molecules which are typical for fibroblastic tissue. This matrix composition was not identical with less differentiated (nonchondroid) areas of grade 2 and 3 conventional chondrosarcomas.〈section xml:id="abs1-2"〉〈title type="main"〉ConclusionsOur results confirm the chondroid nature of the differentiated portion of de-differentiated chondrosarcoma and indicate a nonchondrocytic nature of the nonchondroid portion. De-differentiated chondrosarcoma should not be considered as a ‘de’-differentiated chondrosarcoma (grade 4 neoplasm), but as a tumour entity showing two types of mesenchymal differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1998.00456.x
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  • 3
    Electronic Resource
    Electronic Resource
    Transcriptional and translational regulation of IL-1α and IL-1β account for the control of IL-1 in experimental yersiniosis
    Amsterdam : Elsevier
    Cytokine 6 (1994), S. 504-511 
    Details
    ISSN: 1043-4666
    Keywords: IL-1α and IL-1β ; transcription ; translation ; yersinia-infection
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/1043-4666(94)90078-7
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  • 4
    Electronic Resource
    Electronic Resource
    Localization and characterization of the response of chondrocytes to mechanical load using in-situ hybridization
    Amsterdam : Elsevier
    Matrix Biology 14 (1994), S. 378 
    Details
    ISSN: 0945-053X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0945-053X(94)90089-2
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  • 5
    Electronic Resource
    Electronic Resource
    In situ hybridization studies on the expression of type X collagen in fetal human cartilage
    Amsterdam : Elsevier
    Developmental Biology 148 (1991), S. 562-572 
    Details
    ISSN: 0012-1606
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0012-1606(91)90274-7
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  • 6
    Electronic Resource
    Electronic Resource
    Combined fitting of Ulysses/COMPTEL GRB spectra (1995)
    Springer
    Astrophysics and space science 231 (1995), S. 165-168 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00658609
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  • 7
    Electronic Resource
    Electronic Resource
    Variation with Age in the Pattern of Type X Collagen Expression in Normal and Scoliotic Human Intervertebral Discs (1998)
    Springer
    Calcified tissue international 63 (1998), S. 263-268 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Type X collagen — Nondegenerate discs — Scoliotic discs — Endplate — Hypertrophic chondrocyte phenotype — Matrix calcification.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The distribution and expression of type X collagen, a calcium-binding collagen, which is a marker of hypertrophic chondrocytes and thought to be involved in cartilage calcification, was examined in situ in nondegenerate (grade I or II) human discs taken at autopsy over a wide age range (fetal–〉80 years) and also in scoliotic discs removed at surgery. In the fetal vertebral column, type X collagen was strongly expressed in the hypertrophic chondrocytes of the endplate, but was not seen in other areas. In the cartilaginous endplate of adults, it was found over the whole age range examined, with intensity increasing with age. In the disc matrix itself, type X collagen was demonstrated around individual cells from all individuals older than 50 years, but not in any fetal or autopsy disc from individuals younger than 40 years. In scoliotic discs, however, focal type X collagen expression was seen in 3/8 patients younger than 40 years including one 12-year-old. No type X collagen was found in the outer annulus in any autopsy or scoliotic disc, supporting the idea that cells of the outer annulus are phenotypically distinct from cells of the inner annulus and the nucleus. Our results demonstrate for the first time that type X collagen is a possible gene product of the intervertebral disc cells and a potential biochemical component of the disc matrix. They indicate that with age or in scoliosis, some cells from the inner annulus or nucleus of the disc differentiate to the hypertrophic chondrocyte phenotype. This might be the initiating event for the abnormal calcification described in aged and scoliotic discs in other studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900524
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  • 8
    Electronic Resource
    Electronic Resource
    Knorpelknochentransplantation versus autogene Chondrocytentransplantation Eine prospektive vergleichende klinische Studie (2000)
    Springer
    Der Chirurg 71 (2000), S. 1090-1097 
    Details
    ISSN: 1433-0385
    Keywords: Schlüsselwörter: Gelenkknorpeldefekt ; autologe Chondrocytentransplantationen ; autogene osteochondrale Transplantationen ; Knorpelbiologie. ; Keywords: Full-thickness cartilage defect ; Autologous chondrocyte transplantation ; Autologous osteochondral transplantation ; Cartilage biology.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. Introduction: The treatment of full-thickness cartilage defects still represents a problem that has not yet been solved satisfactorily. Current methods used to cover defects in the knee joint are osteochondral cylinder transplantation (OCT) and autologous chondrocyte transplantation (ACT). Methods: With a prospective clinical investigation, at the time being with 2-year results, we have examined ACT in comparison to OCT in 20 patients with regard to clinical and histomorphological (histology, immunohistochemistry, RES) outcome. Results: We found equally good results with both methods in Lysholm, Meyers and Tegner Activity Scores. Histomorphologic evaluation of biopsies obtained by arthroscopy after ACT showed a defect filling in all cases, mainly with fibrous cartilage, while localized areas of hyalinelike regenerative cartilage were documented near the base.We did not see any histomorphologically visible change in the transplants after OCT. Conclusion: At the time we prefer OCT instead of ACT given the correct indication.
    Notes: Zusammenfassung. Einleitung: Die Behandlung tiefreichender Knorpelschäden stellt nach wie vor ein noch nicht zufriedenstellend gelöstes Problem dar. Aktuelle Methoden zur Defektdeckung am Kniegelenk sind die osteochondrale Zylindertransplantation (OCT) und die autogene Chondrocytentransplantation (ACT). Methoden: Im Rahmen einer prospektiv angelegten klinischen Untersuchung mit derzeit 2 Jahresergebnissen haben wir die ACT im Vergleich zur OCT bei jeweils 20 Patienten hinsichtlich des klinischen und histomorphologischen (Histologie, Immunhistochemie, RES ) Outcome überprüft. Ergebnisse: Hierbei fand sich bei beiden Methoden im Lysholm-, Meyers- sowie dem Tegner-Aktivitäts-Score ein gleich gutes Ergebnis. Die histomorphologische Auswertung der arthroskopisch gewonnenen Biopsierate nach ACT zeigten eine Defektfüllung vornehmlich mit Faserknorpel, wobei basisnah sich begrenzte Areale hyalinähnlicher Knorpelregenerate nachweisen ließen. Eine histomorphologisch erkennbare Veränderung der Transplantate nach OCT sahen wir nicht. Schlußfolgerung: Die OCT wird derzeit von uns der ACT bei korrekter Indikationsstellung vorgezogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040051184
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  • 9
    Electronic Resource
    Electronic Resource
    Knorpelanabolismus und Knorpeldestruktion bei der Arthrose – die Rolle der Chondrozyten (1998)
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. 178-178 
    Details
    ISSN: 0340-1855
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930050083
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  • 10
    Electronic Resource
    Electronic Resource
    Rectal stricture associated with the long-term use of ibuprofen suppositories (2000)
    Springer
    Zeitschrift für Rheumatologie 59 (2000), S. 348-351 
    Details
    ISSN: 0340-1855
    Keywords: Key words Rectal stricture –¶cyclooxygenase inhibitor –¶ibuprofen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Here, we report the case of a 64-year-old woman who suffered from chronic lower backache for which she received ibuprofen suppositories. The patient was admitted to the hospital with a suspected rectal tumor. Clinical examination did not reveal any abnormal finding apart from a mild, bilateral peritibial edema. On rectal examination, an area of stenosis was detected approximately 7 cm above the anal verge. All laboratory parameters, including different tumor markers, were within normal range. Pelvic CT scan and colonoscopy revealed a circular rectal stenosis with severe destruction of the rectal mucosa. The rectal biopsy taken during endoscopy showed severe acute and chronic ulceration, chronic granulation and fibrosis with lymphocytic infiltration. After exclusion of sexually transmitted diseases such as syphilis and lymphogranuloma venerium or exposure to drugs as a possible cause of rectal stenosis, the history in this particular case suggests that the prolonged use of the cyclooxygenase (COX) inhibitor ’’ibuprofen” as a suppository is the cause of mucosal destruction and rectal stenosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930070058
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