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  • 1
    Electronic Resource
    Electronic Resource
    The reproduction, age and growth of the spotted rockling (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of fish biology 62 (2003), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Biology of the Macaronesian endemic rockling Gaidropsarus guttatus was studied in the Azores. The overall sex ratio from the samples was highly in favour of females (1 : 6·33). The growth parameters were L∞ = 24·23, k = 1·219 and t0 = −0·059. Fish matured at 15 cm LT and the spawning season was strongly clustered in April.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1095-8649.2003.00111.x
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  • 2
    Electronic Resource
    Electronic Resource
    Reproductive biology and recruitment of the white sea bream in the Azores (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of fish biology 63 (2003), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The life history of the white sea bream Diplodus sargus in the Azores showed a pattern consistent with digynic hermaphroditism achieving sexual maturity during the second year of life, at 16·7 cm LT. Spawning occurred from March to June at temperatures between 15 and 17° C and the onset and duration of spawning season in the sea bream appeared to be influenced by sea water temperatures. As latitude decreased, both in the northern and southern hemispheres, the spawning season of D. sargus populations started earlier and extended longer, highlighting the potential importance of temperature to the onset and duration of reproduction in this species. Settlement took place from late May to July, and settlers remained in the nursery area for c. 2·5 months. Emigration from the nursery area to join shoals of juveniles occurred from late July to September.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1095-8649.2003.00129.x
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  • 3
    Electronic Resource
    Electronic Resource
    Enzymatic inactivation of bradykinin by rat brain neuronal perikarya (1989)
    Springer
    Cellular and molecular neurobiology 9 (1989), S. 379-400 
    Details
    ISSN: 1573-6830
    Keywords: isolated nuerons ; bradykinin inactivation ; thiol-endopeptidase ; endopeptidase 24.11 ; angiotensin-converting enzyme ; prolyl endopeptidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Bradykinin (Bk; Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg8) inactivation by bulk isolated neurons from rat brain is described. 2. Bk is rapidly inactivated by neuronal perikarya (4.2 ± 0.6 fmol/min/cell body). 3. Sites of inactivating cleavages, determined by a kininase bioassay combined with a time-course Bk-product analysis, were the Phe5-Ser6, Pro7-Phe8, Gly4-Phe5, and Pro3-Gly4 peptide bonds. The cleavage of the Phe5-Ser6 bond inactivated Bk at least five fold faster than the other observed cleavages. 4. Inactivating peptidases were identified by the effect of inhibitors on Bk-product formation. The Phe5-Ser6 bond cleavage is attributed mainly to a calcium-activated thiol-endopeptidase, a predominantly soluble enzyme which did not behave as a metalloenzyme upon dialysis and was strongly inhibited byN-[1(R,S)-carboyx-2-phenylethyl]-Ala-Ala-Phe-p-aminobenzoate and endo-oligopeptidase A antiserum. Thus, neuronal perikarya thiol-endopeptidase seems to differ from endo-oligopeptidase A and endopeptidase 24.15. 5. Endopeptidase 24.11 cleaves Bk at the Gly4-Phe5 and, to a larger extent, at the Pro7-Phe8 bond. The latter bond is also cleaved by angiotensin-converting enzyme (ACE) and prolyl endopeptidase (PE). PE also hydrolyzes Bk at the Pro3-Gly4 bond. 6. Secondary processing of Bk inactivation products occurs by (1) a rapid cleavage of Ser6-Pro7-Phe8-Arg8 at the Pro7-Phe8 bond by endopeptidase 24.11, 3820ACE, and PE; (2) a bestatin-sensitive breakdown of Phe8-Arg9; and (3) conversion of Arg1-Pro7 to Arg1-Phe5, of Gly4-Arg9 to both Gly4-Pro7 and Ser6-Arg9, and of Phe5-Arg9 to Ser6-Arg9, Phe8-Arg9, and Ser6-Pro7, by unidentified peptidases. 7. A model for the enzymatic inactivation of bradykinin by rat brain neuronal perikarya is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711417
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  • 4
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    Contribution to the knowledge of the coastal marine fishes of São Tomé Island (Gulf of Guinea) (2005)
    Details
    Publication Date: 2021-05-19
    Description: Little is known about the ichthyofauna of the São Tomé and Príncipe archipelago. Since the early works of Osório, at the turn of the century, only few attempts were made to update and complete existing knowledge on fish systematics and biodiversity from this area. Over the past few years, however, several surveys made it possible to start an inventory of the coastal fishes for the archipelago. These are mainly based on specimens that where captured or observed whilst diving and also on fishes landed on beaches by local artisanal fishermen. A total of 124 species belonging to 108 genera and 61 families was identified. Some specimens, including Serranidae, Gobiidae and Labridae probably belong to undescribed species and are currently being studied.
    Description: Published
    Keywords: Fishes ; Gulf of Guinea ; São Tomé e Principe ; Check lists ; Marine fish ; Ichthyofauna
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
    Format: 291379 bytes
    Format: application/pdf
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  • 5
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    Pesca de Arrasto e Linha na Baia de Inhambane: 1998 (2021)
    In:  http://aquaticcommons.org/id/eprint/7699 | 424 | 2012-02-02 08:32:43 | 7699 | Instituto de Investigação Pesqueira, Mozambique
    Details
    Publication Date: 2021-07-05
    Description: The fishing activity in Inhambane Bay is still strictly artisanal, with predominance of trawl and line fishing among other methods. Trawl fishing in particular, is considered to be the most important fishing method in terms of revenue and potential for the future.
    Description: A check list of species found in the area studied is included as an annex.
    Keywords: Fisheries ; Information Management ; Mozambique ; Inhambane Bay ; Ambligaster sirm ; Decapterus russelli ; Southern African marine environment ; trawl fishing
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: 1-17
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  • 6
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    Human T-Lymphotropic Virus Type 1-Induced Overexpression of Activated Leukocyte Cell Adhesion Molecule (ALCAM) Facilitates Trafficking of Infected Lymphocytes through the Blood-Brain Barrier [Virus-Cell Interactions] (2016)
    The American Society for Microbiology (ASM)
    Details
    Publication Date: 2016-07-28
    Description: Human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of a slowly progressive neurodegenerative disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This disease develops upon infiltration of HTLV-1-infected lymphocytes into the central nervous system, mostly the thoracic spinal cord. The central nervous system is normally protected by a physiological structure called the blood-brain barrier (BBB), which consists primarily of a continuous endothelium with tight junctions. In this study, we investigated the role of activated leukocyte cell adhesion molecule (ALCAM/CD166), a member of the immunoglobulin superfamily, in the crossing of the BBB by HTLV-1-infected lymphocytes. We demonstrated that ALCAM is overexpressed on the surface of HTLV-1-infected lymphocytes, both in chronically infected cell lines and in primary infected CD4 + T lymphocytes. ALCAM overexpression results from the activation of the canonical NF-B pathway by the viral transactivator Tax. In contrast, staining of spinal cord sections of HAM/TSP patients showed that ALCAM expression is not altered on the BBB endothelium in the context of HTLV-1 infection. ALCAM blockade or downregulation of ALCAM levels significantly reduced the migration of HTLV-1-infected lymphocytes across a monolayer of human BBB endothelial cells. This study suggests a potential role for ALCAM in HAM/TSP pathogenesis. IMPORTANCE Human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of a slowly progressive neurodegenerative disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This disease is the consequence of the infiltration of HTLV-1-infected lymphocytes into the central nervous system (CNS), mostly the thoracic spinal cord. The CNS is normally protected by a physiological structure called the blood-brain barrier (BBB), which consists primarily of a continuous endothelium with tight junctions. The mechanism of migration of lymphocytes into the CNS is unclear. Here, we show that the viral transactivator Tax increases activated leukocyte cell adhesion molecule (ALCAM/CD166) expression. This molecule facilitates the migration of lymphocytes across the BBB endothelium. Targeting this molecule could be of interest in preventing or reducing the development of HAM/TSP.
    Print ISSN: 0022-538X
    Electronic ISSN: 1098-5514
    Topics: Medicine
    Published by The American Society for Microbiology (ASM)
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  • 7
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    A hot Jupiter transiting a mid-K dwarf found in the pre-OmegaCam Transit Survey (2013)
    Oxford University Press
    Details
    Publication Date: 2013-10-12
    Description: We describe the pre-OmegaTranS project, a deep survey for transiting extra-solar planets in the Carina region of the Galactic disc. In 2006–2008, we observed a single dense stellar field with a very high cadence of ~2 min using the European Southern Observatory Wide Field Imager at the La Silla Observatory. Using the Astronomical Wide-field Imaging System for Europe environment and the Munich Difference Imaging Analysis pipeline, a module that has been developed for this project, we created the light curves of 16 000 stars with more than 4000 data points which we searched for periodic transit signals using a box-fitting least-squares detection algorithm. All light curves are publicly available. In the course of the pre-OmegaTranS project, we identified two planet candidates – POTS-1b and POTS-C2b – which we present in this work. With extensive follow-up observations we were able to confirm one of them, POTS-1b, a hot Jupiter transiting a mid-K dwarf. The planet has a mass of 2.31 ± 0.77  M Jup , a radius of 0.94 ± 0.04  R Jup and a period of P  = 3.16 d. The host star POTS-1 has a radius of 0.59 ± 0.02 R and a mass of 0.70 ± 0.05 M . Due to its low apparent brightness of I  = 16.1 mag, the follow-up and confirmation of POTS-1b was particularly challenging and costly.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 8
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    Exosomes from HTLV-1-infected Cells Contain Tax Protein [Cell Biology] (2014)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2014-08-09
    Description: Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. The HTLV-1 transactivator protein Tax controls many critical cellular pathways, including host cell DNA damage response mechanisms, cell cycle progression, and apoptosis. Extracellular vesicles called exosomes play critical roles during pathogenic viral infections as delivery vehicles for host and viral components, including proteins, mRNA, and microRNA. We hypothesized that exosomes derived from HTLV-1-infected cells contain unique host and viral proteins that may contribute to HTLV-1-induced pathogenesis. We found exosomes derived from infected cells to contain Tax protein and proinflammatory mediators as well as viral mRNA transcripts, including Tax, HBZ, and Env. Furthermore, we observed that exosomes released from HTLV-1-infected Tax-expressing cells contributed to enhanced survival of exosome-recipient cells when treated with Fas antibody. This survival was cFLIP-dependent, with Tax showing induction of NF-κB in exosome-recipient cells. Finally, IL-2-dependent CTLL-2 cells that received Tax-containing exosomes were protected from apoptosis through activation of AKT. Similar experiments with primary cultures showed protection and survival of peripheral blood mononuclear cells even in the absence of phytohemagglutinin/IL-2. Surviving cells contained more phosphorylated Rb, consistent with the role of Tax in regulation of the cell cycle. Collectively, these results suggest that exosomes may play an important role in extracellular delivery of functional HTLV-1 proteins and mRNA to recipient cells.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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  • 9
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    Northern African Strains of Human T-Lymphotropic Virus Type 1 Arose from a Recombination Event [Genetic Diversity and Evolution] (2014)
    The American Society for Microbiology (ASM)
    Details
    Publication Date: 2014-08-05
    Description: Although recombination is a major source of genetic variability in retroviruses, no recombinant strain had been observed for human T-lymphotropic virus type 1 (HTLV-1), the first isolated human-pathogenic retrovirus. Different genotypes exist for HTLV-1: Genotypes b and d to g are restricted to central Africa, while genotype c is only endemic in Australo-Melanesia. In contrast, the cosmopolitan genotype a is widely distributed. We applied a combination of phylogenetics and recombination analysis approaches to a set of new HTLV-1 sequences, which we collected from 19 countries throughout Africa, the continent where the virus has the largest endemic presence. This led us to demonstrate the presence of recombinants in HTLV-1. Indeed, the HTLV-1 strains currently present in North Africa have originated from a recombinant event between strains from Senegal and West Africa. This recombination is estimated to have occurred around 4,000 years ago. This recombination seems to have been generated during reverse transcription. In conclusion, we demonstrate that, albeit rare, recombination can occur in HTLV-1 and may play a role in the evolution of this retrovirus. IMPORTANCE A number of HTLV-1 subtypes have been described in different populations, but none of the genetic differences between these subtypes have been ascribed to recombination events. Here we report an HTLV-1 recombinant virus among infected individuals in North Africa. This demonstrates that, contrary to what was thought, recombination can occur and could play a role in the evolution of HTLV-1.
    Print ISSN: 0022-538X
    Electronic ISSN: 1098-5514
    Topics: Medicine
    Published by The American Society for Microbiology (ASM)
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  • 10
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    Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response [Antiviral Agents] (2017)
    The American Society for Microbiology (ASM)
    Details
    Publication Date: 2017-09-23
    Description: De novo pyrimidine biosynthesis is a key metabolic pathway involved in multiple biosynthetic processes. Here, we identified an original series of 3-(1 H -indol-3-yl)-2,3-dihydro-4 H -furo[3,2- c ]chromen-4-one derivatives as a new class of pyrimidine biosynthesis inhibitors formed by two edge-fused polycyclic moieties. We show that identified compounds exhibit broad-spectrum antiviral activity and immunostimulatory properties, in line with recent reports linking de novo pyrimidine biosynthesis with innate defense mechanisms against viruses. Most importantly, we establish that pyrimidine deprivation can amplify the production of both type I and type III interferons by cells stimulated with retinoic acid-inducible gene 1 (RIG-I) ligands. Altogether, our results further expand the current panel of pyrimidine biosynthesis inhibitors and illustrate how the production of antiviral interferons is tightly coupled to this metabolic pathway. Functional and structural similarities between this new chemical series and dicoumarol, which was reported before to inhibit pyrimidine biosynthesis at the dihydroorotate dehydrogenase (DHODH) step, are discussed.
    Print ISSN: 0066-4804
    Electronic ISSN: 1098-6596
    Topics: Biology , Medicine
    Published by The American Society for Microbiology (ASM)
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