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  • 1
    Online Resource
    Online Resource
    San Diego :Elsevier Science & Technology,
    Keywords: Flood forecasting. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (485 pages)
    Edition: 1st ed.
    ISBN: 9780128018590
    DDC: 551.4/89
    Language: English
    Note: Front Cover -- Flood Forecasting: A Global Perspective -- Copyright -- Dedication -- Contents -- Contributors -- Foreword -- Acknowledgments -- Flood Forecasting: A Global Perspective -- 1 Introduction -- 2 National and Regional Flood Forecasting Systems -- 3 Continental Modeling and Monitoring -- 3.1 Challenges Facing Flood Forecasting -- 3.2 Forecast Dissemination Issues -- 4 Summary -- References -- Part 1: National and Regional Flood Forecasting Systems -- Chapter 1: Australian Bureau of Meteorology Flood Forecasting and Warning -- 1 Introduction -- 2 Demographics, Climate, and Floods of Australia -- 3 History of Flood Forecasting at the Bureau of Meteorology -- 4 Current Characteristics of the Bureau and Its Services -- 5 Operational Forecasting and Systems -- 5.1 Data Systems and Quality Control -- 5.2 Modeling for Flood Forecasting -- 5.2.1 Statistical Models -- 5.2.2 Hydrologic Simulation Models -- 5.2.2.1 Reservoir Modeling -- 5.2.2.2 Weather Predictions (QPF) -- 5.2.2.3 Data Assimilation -- 5.3 Production Environment: HYMODEL and HyFS -- 5.4 Role of Expertise -- 6 Operational Challenges -- 6.1 Data and Services -- 6.2 Modeling and Forecasting -- 6.3 Warning and Communication -- 6.4 Institutional Factors -- 6.5 Understanding User Needs -- 7 Future Directions -- 8 Summary -- Acknowledgments -- References -- Chapter 2: Hydrological Forecasting Practices in Brazil -- 1 Introduction -- 2 Geography, Climate, and Floods in Brazil -- 3 General Overview of Hydrological forecasts in Brazil -- 4 Examples of Operational and Preoperational Forecasting Systems -- 4.1 Doce River Flood Forecasting System Maintained by the Brazilian Geological Service (CPRM) -- 4.2 Upper Uruguay River Basin Hydropower Reservoir Inflow Forecasting System -- 4.3 São Francisco River Basin Ensemble Forecasting System. , 4.4 Tocantins River Basin Forecasting System -- 4.5 Experimental River Flow Forecasts in the Amazon -- 5 Conclusions -- References -- Chapter 3: The Development and Recent Advances of Flood Forecasting Activities in China -- 1 Introduction -- 2 Evolution of Flood Control and Management in China -- 2.1 Start-up Phase: Before the Mid 1970s -- 2.2 Development Phase: From the Mid 1970s to 1998 -- 2.3 Improvement Phase: From 1998 to the Present Day -- 3 Development of Operational Hydrological Forecasting and Prediction in China -- 3.1 Hydrological Information and Forecasting Administration -- 3.2 Hydrological Monitoring and Data Transmission -- 3.2.1 Hydrological Monitoring -- 3.2.2 Data Transmission -- 3.3 Hydrological Forecasting Method and Model -- 3.4 Hydrological Forecasting System -- 3.5 Application of New Technology in Hydrological Forecasting and Prediction -- 3.5.1 Rainfall and Flood Joint Forecast -- 3.5.2 Interactive Forecast Program -- 3.5.3 Application of DEM, RS, and GIS Technologies -- 4 Conclusions and Outlook -- References -- Chapter 4: A Regional Perceptive of Flood Forecasting and Disaster Management Systems for the Congo River Basin -- 1 Introduction -- 2 Physiographic Setting and Physical Characteristics of the Congo River Basin -- 3 Flood-bearing Processes in the Congo River Basin -- 3.1 Hydro Climate Processes -- 3.2 A Wavelet Approach for Understanding Hydro Climate Processes in the Congo River Basin -- 3.3 Land Use Dynamics -- 3.4 Climate Change -- 4 Trends and Socio-Economic Impacts of Floods in the Congo River Basin -- 5 Current Status of Flood Forecasting and Disaster Management Systems in the Congo River Basin -- 5.1 Hydrometeorological Services and Monitoring -- 5.1.1 Ground-Based Monitoring -- 5.1.2 Satellite-Based Observation -- 5.2 Data Management -- 5.3 Rainfall-Runoff Modeling and Forecasting. , 5.4 Institutional Arrangement and Flood Management Policy -- 6 Conclusion -- References -- Chapter 5: Flood Forecasting in Germany - Challenges of a Federal Structure and Transboundary Cooperation -- 1 Introduction -- 2 International Cooperation - The Rhine Basin -- 3 Measured Meteorological and Hydrological Data -- 4 Numerical Weather Predictions -- 5 Snowmelt Forecasts -- 6 Regional Organization and Transboundary Data Exchange -- 7 River Forecasting Models -- 7.1 The LARSIM Water Balance Model -- 7.2 The WAVOS Water Level Forecasting System -- 7.3 Components of WAVOS Rhein -- 8 Forecast Dissemination -- 9 Flood Partnerships -- 10 Summary -- References -- Chapter 6: Operational Flood Forecasting in Israel -- 1 Introduction -- 2 Climate and Hydrological Characteristics of Israel -- 3 The Flood Forecasting Modeling System in Israel -- 3.1 Flood Forecasting at the Israeli Domain Using the WRF-Hydro Model -- 3.2 Flood Forecasting for the Tel Aviv Metropolis Using the HEC-HMS Model -- 4 Summary -- References -- Chapter 7: Operational Hydrologic Forecast System in Russia -- 1 Introduction -- 2 Hydrological Practices in Russia -- 3 The Hydrologic Forecasting System of the Roshydromet -- 4 Hydrometeorological Data -- 5 Long-Range Spring Flood Predictions -- 6 Early Warning Flood Forecasting Systems -- 7 Conclusions -- References -- Chapter 8: Increasing Early Warning Lead Time Through Improved Transboundary Flood Forecasting in the Gash River Basin, Horn of Africa -- 1 Introduction -- 2 Building a Flood Forecast and Early Warning System -- 3 Geographical Setting of the Gash River Basin -- 4 The Modeling Approach -- 4.1 Topographic Model Setup -- 4.2 Spatial and Nonspatial Databases -- 4.3 Terrain Processing -- 4.4 Hydrological Parameter Extraction -- 4.5 Hydrometeorological Model Setup. , 4.6 Model Setup and Simulation Run -- 4.7 Model Calibration and Validation -- 5 Results and Discussion -- 6 Conclusion -- Acknowledgments -- References -- Chapter 9: Flood Forecasting - A National Overview for Great Britain -- 1 Background and Catalysts for Change -- 1.1 Introduction -- 1.2 Flood Risk in England, Wales, and Scotland -- 1.3 Flood Forecasting and Warning Landscape 1998-2009 -- 1.4 The Catalyst for Change: Summer 2007 Floods -- 1.5 The Pitt Review and the Establishment of the Flood Forecasting Centre -- 1.6 Establishment of the Scottish Flood Forecasting Service -- 2 Countrywide Flood Forecasting Modeling Approach -- 2.1 Drivers, History, and Context for a Countrywide Flood Forecasting Approach -- 2.2 Countywide Fluvial Flood Forecasting -- 2.3 Countrywide Surface Water Flood Forecasting -- 2.4 Countrywide Coastal Flood Forecasting -- 2.5 Countrywide Groundwater Flood Forecasting -- 3 Forecast Dissemination Protocols and Products -- 3.1 Flood Forecasting and Warning Dissemination -- 3.2 Flood Forecast Products and Services -- 4 Measuring Performance of the Flood Forecasting and Warning Service -- 4.1 Introduction -- 4.2 Assessing Local Model Performance -- 4.3 National Assessment of Local Model, and National Model Performance -- 4.4 Formal National Measure of Overall Performance of the Forecasting and Warning Service -- 5 Future Forecasting Challenges -- 5.1 Recent Experience and Key Research Areas -- 5.2 Nowcasting Science and Short Lead Times -- 5.3 Observations and Instrumentation -- 5.4 Estuaries and Coastal Modeling -- 5.5 Integrated Modeling and Forecasting -- 5.6 Longer Lead Time Forecasting: Day 6 to Seasonal -- 5.7 People, Skills, Interpretation, and Engagement -- Disclaimer -- Dedication -- References -- Chapter 10: Flood Forecasting in the United States NOAA /National Weather Service. , 1 Introduction -- 2 History -- 3 A Brief History of Models and Modeling Systems Used by the NWS -- 3.1 NWS River Forecasting Paradigm -- 3.2 Antecedent Precipitation Index (API) Model -- 3.3 Data Acquisition and Processing -- 3.3.1 U.S. Geological Survey Stream Gaging Program -- 3.3.2 Cooperative Observer Program -- 3.3.3 HADS -- 3.3.4 Community Collaborative Rain, Hail and Snow (CoCoRaHS) Network -- 3.4 NWSRFS -- 3.4.1 Operational Forecast System (OFS) -- 3.4.2 Interactive Forecast Program (IFP) -- 3.4.3 Calibration System (CS) -- 3.4.4 Extended Streamflow Prediction (ESP) System -- 3.4.5 Flash Flood Guidance (FFG) System -- 3.5 Models -- 3.6 Methods -- 3.6.1 Quantitative Precipitation Estimation (QPE) -- 3.6.2 Quantitative Precipitation Forecast (QPF) -- 3.6.3 Temperature Estimation -- 4 Current Models and Modeling System -- 4.1 Community Hydrologic Prediction System (CHPS) -- 4.2 Models -- 4.2.1 Research Distributed Hydrologic Model (RDHM) Model -- 5 Current Operations -- 5.1 AWIPS -- 5.2 AHPS -- 5.3 Quantitative Precipitation Estimation (QPE) -- 5.3.1 Multisensor Precipitation Estimator (MPE) -- 5.3.2 Multi-Radar, Multi-Sensor (MRMS) System -- 5.4 Hydrologic Ensemble Forecast System (HEFS) -- 5.5 Forecast Products -- 5.6 Forecast Evaluation -- 5.6.1 Forecast Verification -- 5.6.2 Service Assessment -- 6 Additional Topics -- 6.1 Flash Flood Watches and Warnings -- 6.2 AFWS -- 7 Future Developments -- 7.1 Integrated Water Resources Science and Services (IWRSS) -- 7.2 National Water Center -- References -- Part 2: Continental Modeling and Monitoring - The Future? -- Chapter 11: On the Operational Implementation of the European Flood Awareness System (EFAS) -- 1 Introduction -- 2 EFAS Structure -- 3 Data Acquisition -- 4 Model Components -- 4.1 Meteorological Models -- 4.2 LISFLOOD -- 5 Generating Forecasts. , 5.1 Infrastructure.
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  • 2
    Online Resource
    Online Resource
    San Diego :Elsevier,
    Keywords: Water resources development. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (488 pages)
    Edition: 1st ed.
    ISBN: 9780128127834
    DDC: 333.9100954
    Language: English
    Note: Front Cover -- Indus River Basin: Water Security and Sustainability -- Copyright -- Dedication -- Contents -- Contributors -- Foreword -- Acknowledgments -- Part I: Indus River Basin-Past, Present and Future -- Introduction: Introduction of Indus River Basin: Water Security and Sustainability -- 1. Indus River Basin -- 2. A Historical Perspective of the IRB -- 3. Synopsis of This Book -- 3.1. Part I-Indus River Basin-Past, Present, and Future -- 3.2. Part II-Climate-Ecohydrology of Indus River Basin -- 3.3. Part III-Water and Food Security of Indus River Basin -- 3.4. Part IV-Water Extremes in Indus River Basin -- 3.5. Part V-Water Management in Indus River Basin -- References -- Further Reading -- Chapter 1: Water Resources Modeling and Prospective Evaluation in the Indus River Under Present and Prospective Climate C ... -- 1.1. Introduction -- 1.1.1. Water Resources of the Hindu Kush, Karakoram, and Himalaya -- 1.1.2. The Karakoram Anomaly -- 1.2. Climate and Hydrology of the Upper Indus Basin -- 1.3. Summary of Recent Studies -- 1.3.1. Hydrological Regime of the UIB -- 1.3.2. Recent Evidence of Climate Change and Impact on Water Resources in the UIB -- 1.3.3. Projected Water Resources in the UIB During the 21st Century -- 1.4. A Guideline and Recent Key Study on Monitoring and Modeling High-Altitude Catchments -- 1.4.1. A Method to Model High-Altitude Catchments -- 1.4.2. A Paradigmatic Case Study, Shigar River of Gilgit-Baltistan -- 1.4.2.1. The Shigar River -- 1.4.2.2. Data for High-Altitude Catchment Modeling -- 1.4.2.3. Glacio-Hydrological Modeling in High-Altitude Catchments -- 1.4.2.4. Future Hydrology of the Shigar River -- 1.4.2.5. Future Cryospheric Behavior in the Shigar River -- 1.4.2.6. Potential for Increased Floods Within the UIB: The Case of Shigar River -- 1.5. Discussion -- 1.5.1. Hydrological Trends Within the UIB. , 1.5.2. The Need for Hydrological Monitoring in the UIB -- 1.5.3. A Proposed Hydrometric Network for the CKNP -- 1.6. Conclusions -- Acknowledgments -- References -- Further Reading -- Chapter 2: Challenges in Forecasting Water Resources of the Indus River Basin: Lessons From the Analysis and Modeling of ... -- 2.1. Introduction -- 2.2. Lessons From Atmospheric Models -- 2.2.1. Skillful Prediction -- 2.2.2. Prediction Skill and Model Biases -- 2.2.3. Spring Snow Over Eurasia -- 2.2.4. The Effect of Resolution -- 2.2.5. Multidecadal Timescales -- 2.3. Lessons From Uncertainty -- 2.3.1. The Complexity of Uncertainty -- 2.3.2. Uncertainty in Downscaled Output -- 2.3.2.1. Assessing Uncertainty: A Case Study -- 2.3.2.2. Investigating Seasonal Changes in the Case Study -- 2.3.2.3. Is Cooling a Plausible Result? -- 2.3.3. Heterogeneity in the Estimates -- 2.3.4. Projections of Climate Extremes -- 2.4. Lessons From Hydrological Projections -- 2.4.1. Cascade of Uncertainty -- 2.4.2. Overview of a Few Hydrological Studies -- 2.4.2.1. Results from NORINDIA -- 2.4.2.2. The Role of Glacier Melt -- 2.5. Conclusion -- Appendix A. The NORINDIA Project in a Nutshell -- A. Case Study of the Beas River System -- B. Assessment of the CFSR Reanalysis Product -- Appendix B. Dynamical Downscaling of NorESM and ERA-Interim Data Sets -- Appendix C. Bayesian Method for Estimating the Mean Surface Temperature -- Acknowledgments -- References -- Chapter 3: Past and Future Glacier Changes in the Indus River Basin -- 3.1. Introduction -- 3.2. Past Glacier Changes -- 3.2.1. Area and Length Changes -- 3.2.2. Mass Changes -- 3.3. Future Trends -- 3.4. Discussion and Conclusions -- Acknowledgments -- References -- Part II: Climate-Eco-Hydrology of Indus River Basin -- Chapter 4: Probabilistic Precipitation Analysis in the Central Indus River Basin -- 4.1. Introduction. , 4.2. Data and Methods -- 4.2.1. Study Area -- 4.2.2. In Situ Observations -- 4.2.3. Atmospheric Reanalyses -- 4.3. Application of the Model Conditional Processor -- 4.3.1. Predictive Uncertainty -- 4.3.2. Normalization of Variables -- 4.3.3. Precipitation: Normal Distributions -- 4.3.4. Back-Transformation Into the Original Space -- 4.4. Application and Results -- 4.4.1. Calibration -- 4.4.2. Performance Indicators -- 4.4.3. Validation -- 4.5. Conclusions -- Acknowledgments -- Appendix. The Model Conditional Processor -- References -- Chapter 5: Glaciers in the Indus Basin -- 5.1. Introduction -- 5.2. Data and Methodology -- 5.3. Glacier Characteristics in the Indus Basin -- 5.3.1. Number, Area, and Estimated Ice Reserves -- 5.3.2. Glacier Area Classes -- 5.3.3. Glacier Elevation -- 5.3.4. Aspects -- 5.3.5. Slope -- 5.3.6. Morphological Glacier Type -- 5.3.7. Clean-Ice and Debris-Covered Glaciers -- 5.3.8. Hypsography -- 5.4. Conclusions -- Acknowledgments -- References -- Further Reading -- Chapter 6: A Review on the Projected Changes in Climate Over the Indus Basin -- 6.1. Introduction -- 6.2. Climate Projection in the Indus Basin -- 6.2.1. Projected Temperature Trends -- 6.2.2. Projected Precipitation Trends -- 6.3. Conclusion -- Acknowledgments -- References -- Chapter 7: A Hydrological Perspective on Interpretation of Available Climate Projections for the Upper Indus Basin -- 7.1. Introduction -- 7.2. Initial Analysis of Ground-Based Data -- 7.2.1. Precipitation -- 7.2.2. Temperature -- 7.3. Hydrological Regimes and Climate Runoff Relationships -- 7.4. Evaluation and Interpretation of Available Climate Projections for the UIB -- 7.5. Available Methods for Downscaling GCM Projections to Finer Spatial Scales -- 7.6. Evaluation of Outputs From Available RCM Historical Period Simulations -- 7.6.1. RCM Skill in Representation of Large-Scale Climate. , 7.6.2. RCM Skill in Representation of the UIB-Karakoram Climate -- 7.7. Vertical Patterns of Projected UIB Climate Change From CORDEX-South Asia -- 7.8. Summary and Priorities for Further Research on the UIB's Future Climate -- References -- Part III: Water and Food Security of Indus River Basin -- Chapter 8: Transboundary Indus River Basin: Potential Threats to Its Integrity -- 8.1. Introduction -- 8.2. Water Sharing Mechanism in Practice -- 8.3. Indus River Basin and Regional Economy -- 8.4. Emerging Threats to the Indus River Basin -- 8.4.1. Growing Population -- 8.4.2. Reduced or Fluctuating Surface Flows -- 8.4.3. Reduced Environmental Flows -- 8.4.4. Accelerated Water Scarcity -- 8.4.5. Rising Water Demand -- 8.4.6. Lower Land and Water Productivity -- 8.4.7. Groundwater Quantity and Quality -- 8.4.8. Hydropower Generation and Energy Crisis -- 8.4.9. Climate Change -- 8.4.10. Aging Treaty -- 8.5. Conclusions -- References -- Further Reading -- Chapter 9: Indo-Ganges River Basin Land Use/Land Cover (LULC) and Irrigated Area Mapping -- 9.1. Introduction -- 9.2. Study Area -- 9.3. Data -- 9.3.1. Satellite Data -- 9.3.2. Ground Data -- 9.3.3. Ideal Spectra Signatures -- 9.3.4. Mapping Land Use/Land Cover -- 9.3.5. Matching Class Spectra With Ideal Spectra to Group Classes Using Spectral Matching Techniques (SMTs) -- 9.3.6. Subpixel Area Calculations -- 9.3.7. Accuracy Assessments -- 9.4. Results and Discussions -- 9.4.1. Spatial Distribution of Croplands in Indo-Ganges Basin -- 9.4.2. Spatial Distribution of Irrigated and Rainfed Croplands in the Indo-Ganges Basin -- 9.4.3. Class Signatures and Onset-Peak-Senescence-Duration of Crops -- 9.4.4. Accuracies and Errors -- 9.4.5. Comparison With District Wise Cropland Statistics -- 9.4.6. Discussion of Methods -- 9.5. Conclusions -- References. , Chapter 10: Increasing Water Productivity in the Agricultural Sector -- 10.1. Introduction -- 10.2. Concepts of Water Productivity -- 10.3. Agricultural Water Productivity Across the Globe -- 10.4. Opportunities for Increasing Water Productivity in Agriculture Sector -- 10.4.1. Plant-Scale Interventions -- 10.4.2. Field-Scale Interventions -- 10.4.3. Irrigation System-Scale Interventions -- 10.4.4. Basin-Scale Interventions -- 10.5. Conclusions -- References -- Chapter 11: Hydrological Cycle Over the Indus Basin at Monsoon Margins: Present and Future -- 11.1. Introduction -- 11.2. Data and Methods -- 11.2.1. Data -- 11.2.2. Methods -- 11.3. Results and Discussion -- 11.3.1. Observed Precipitation -- 11.3.2. Physical Consistency and Realism of CMIP5 Experiments -- 11.3.3. Future Water Budget Changes -- 11.4. Conclusions -- Acknowledgments -- References -- Part IV: Water Extremes in Indus River Basin -- Chapter 12: Water Resources Forecasting Within the Indus River Basin: A Call for Comprehensive Modeling -- 12.1. Introduction -- 12.1.1. Necessity for Hydrological Services -- 12.1.1.1. Pakistan's Needs -- 12.1.2. Hydro-Climatology -- 12.1.3. Flooding -- 12.1.4. Irrigation and Water Resources -- 12.2. Status of Hydrometeorological Monitoring -- 12.3. Status of Hydrological Modeling and Forecasting -- 12.3.1. Pakistan -- 12.3.2. India -- 12.3.3. China -- 12.3.4. Afghanistan -- 12.4. Needed Improvements and Benefits -- 12.4.1. Infrastructure Improvements -- 12.4.2. Improved Capacity Building and Coordination -- 12.4.3. Hydrological Modeling Improvements -- 12.5. Conclusions -- References -- Further Reading -- Chapter 13: Review of Hydrometeorological Monitoring and Forecasting System for Floods in the Indus Basin in Pakistan -- 13.1. Introduction -- 13.2. Floods in the Indus Basin -- 13.3. Hydrometeorological Observation/Monitoring System of Pakistan. , 13.3.1. Hydrometeorological Observation by PMD.
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  • 3
    Keywords: Forschungsbericht
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (10 Seiten, 155,16 KB)
    Edition: Issue: 1.0
    Language: German
    Note: Förderkennzeichen BMWK 50RA1840 [richtig] - 50 RL 1840 [falsch] , Verbundnummer 01184511 , Laufzeit: 01.01.2019 bis 31.12.2021 , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 74 (1952), S. 5740-5744 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 74 (1952), S. 1437-1441 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford BSL : Blackwell Science Ltd
    Molecular microbiology 28 (1998), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The Aspergillus nidulans aflR gene is found within a 60 kb gene cluster that includes ≈24 other genes that putatively function in the production of the aflatoxin-related mycotoxin sterigmatocystin. Previous work showed that AflR is a C6 zinc binuclear cluster protein that is conserved across Aspergillus spp. and functions as a pathway-specific transcription factor in activating expression of other cluster genes. In this report, we demonstrate that A. nidulans AflR (AnAflR) is a 45 kDa protein that binds to the palindromic sequence 5′-TCG(N5)CGA-3′ found in the promoter regions of several aflatoxin and sterigmatocystin cluster genes (stc genes). The in vivo relevance of this AnAflR binding site was assessed by examining the contribution of the three TCG(N5)CGA elements in the 1.1 kb promoter region of stcU using gene fusions with the bacterial uidA gene encoding β-glucuronidase (GUS). By mutating one, two or all three of the AnAflR-binding elements and examining GUS activity in wild-type aflR or ΔaflR A. nidulans strains, we found that stc gene activation required both AnAflR and at least one TCG(N5)CGA AflR binding site.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 14 (1994), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Aspergillus nidulans reproduces asexually by forming thousands of mitotically derived spores atop highly specialized multicellular organs termed conidiophores. We have identified a gene called flbA (for fluffy low brlA expression) that is required for initiation of A. nidulans conidiophore development. flbA mutants form abnormal colonies that have a distinct fluffy phenotype characterized by tightly interwoven aerial hyphae that autolyse as the colony matures. The requirement for fIbA in conidiophore development precedes activation of brlA, a primary regulator of conidiophore development. The wild-type flbA gene was isolated and found to encode a 3.0 kb mRNA that is expressed throughout the A. nidulans asexual life cycle. Overexpression of fIbA using an Inducible promoter resulted in misscheduled expression of brlA in vegetative ceils and caused hyphal tips to differentiate into spore-producing structures. Sequence analysis of a nearly full-length fIbA cDNA clone showed that fibA is predicted to encode a 717-amino-acid polypeptide with 30% identity to the Saccharomyces cerevisiae SST2 protein. SST2 is required by yeast cells for resuming growth following prolonged exposure to yeast mating pheromone and for mating partner discrimination. We propose that fIbA plays a related role in a signalling pathway for Aspergillus conidiophore development.
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 122 (1994), S. 0 
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract A genomic DNA library was constructed from a pathogenic strain of Aspergillus fumigatus using the cosmid vector pCosAX. Cosmid clones with homologies to the rodA, brlA, fluG, flbA or trpC genes from A. nidulans were isolated from the library. Each A. fumigatus clone was used to complement strain of A. nidulans with a mutation in the homologous gene. A spontaneous white spored strain of A. fumigatus was isolated. The mutation was complemented by transforming the strain with a plasmid containing the wA gene from A. nidulans. The results from these experiments indicate a significant degree of structural and functional homology between genes from the organisms. These findings indicate the potential to exploit the methods and information available from A. nidulans to address questions related to human disease caused by A. fumigatus and the ability to use A. nidulans as a surrogate genetic host for characterizing A. fumigatus gene function.
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