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  • 1
    Online Resource
    Online Resource
    Chicago :University of Chicago Press,
    Keywords: Science and state. ; Electronic books.
    Description / Table of Contents: No detailed description available for "The Changing Frontier".
    Type of Medium: Online Resource
    Pages: 1 online resource (441 pages)
    Edition: 1st ed.
    ISBN: 9780226286860
    Series Statement: National Bureau of Economic Research Conference Report
    DDC: 338.9/26
    Language: English
    Note: Intro -- Contents -- Preface -- Introduction by Adam B. Jaffe and Benjamin F. Jones -- The Organization of Scientific Research -- The Geography of Innovation -- Entrepreneurship and Market-Based Innovation -- Historical Perspective on Science Institutions and Paradigms -- Concluding Comments -- References -- I. The Organization of Scientific Research -- 1. Why and Wherefore of Increased Scientific Collaboration by Richard B. Freeman, Ina Ganguli, and Raviv Murciano-Goroff -- 1.1 The Growing Trend of International Collaboration -- 1.2 Survey of Corresponding Authors -- 1.3 Collaborations over Distance -- 1.4 Survey Evidence -- 1.5 Toward an Economics of Scientific Collaborations -- Appendix -- 2. The (Changing) Knowledge Production Function: Evidence from the MIT Department of Biology for 1970-2000 by Annamaria Conti and Christopher C. Liu -- 2.1 Introduction -- 2.2 Empirical Setting -- 2.3 Trends in Scientific Productivity of Graduate Students and Postdocs -- 2.4 Conclusions and Policy Implications -- References -- 3. Collaboration, Stars, and the Changing Organization of Science: Evidence from Evolutionary Biology by Ajay Agrawal, John McHale, and Alexander Oettl -- 3.1 Introduction -- 3.2 Data -- 3.3 Participation: A Broadening Base -- 3.5 Collaboration: Increasing across Distance and Rank -- 3.6 Improved Collaboration Technology and the Distributionof Scientific Output: An Integrating Model -- 3.7 Discussion: Normative Implications of Star Location -- References -- Comment by Julia Lane -- References -- 4. Credit History: The Changing Nature of Scientific Credit by Joshua S. Gans and Fiona Murray -- 4.1 Introduction -- 4.2 Credit and the Organization of Science -- 4.3 Credit History -- 4.4 Formal Model -- 4.5 Some Implications -- 4.6 Conclusions and Future Directions -- References -- II. The Geography of Innovation. , 5. The Rise of International Coinvention by Lee Branstetter, Guangwei Li, and Fransisco Veloso -- 5.1 Introduction -- 5.2 Background -- 5.3 Data Sources and Trends -- 5.4 Empirical Model and Results -- 5.5 Peering inside Coinvention: Lessons from Interviews of Multinational R& -- D Personnel -- 5.6 Conclusions and Implications -- References -- 6. Information Technology and the Distribution of Inventive Activity by Chris Forman, Avi Goldfarb, and Shane Greenstein -- 6.1 Introduction -- 6.2 Data -- 6.3 Empirical Strategy and Results -- Conclusion -- References -- III. Entrepreneurship and Market-Based Innovation -- 7. Innovation and Entrepreneurship in Renewable Energy by Ramana Nanda, Ken Younge, and Lee Fleming -- 7.1 Introduction -- 7.2 Data -- 7.3 Results -- 7.4 Venture Capital Financing of Renewable Energy Start- Ups -- Appendix B: New Measure of Novelty -- References -- 8. Economic Value Creation in Mobile Applications by Timothy F. Bresnahan, Jason P. Davis, and Pai-Ling Yin -- 8.1 Introduction -- 8.2 Innovation in Platform-Based Industries -- 8.3 Matching Apps to Customers: App Store Rankings -- 8.4 Data -- 8.5 App Success is Highly Concentrated -- 8.6 Short-Run Dynamics -- 8.7 "Top List" Implications for Market Development -- 8.8 The Economic Return to the Development of New Apps -- 8.9 Developer Behavior: Platform Choice and Multihoming -- 8.10 Alternative Equilibrium Scenarios -- 8.11 Conclusion -- References -- 9. State Science Policy Experiments by Maryann Feldman and Laura Lanahan -- 9.1 Background on State Science Policy -- 9.2 Methods -- 9.3 Empirical Results -- 9.4 Discussion -- 9.5 Reflective Conclusions -- References -- IV. Historical Perspectives on Science Institutions and Paradigms -- 10. The Endless Frontier: Reaping What Bush Sowed? by Paula Stephan -- 10.1 Introduction. , 10.2 The Scientific Landscape Circa the 1940s and The Endless Frontier -- 10.3 Early Years of the NIH and the NSF -- 10.4 The University Response to Capacity Building: The 1960s -- 10.5 The 1970s-2012 -- 10.6 Taking Stock -- 10.7 Stresses to the System -- 10.8 Concluding Thoughts -- Appendix -- References -- Comment by Bruce A. Weinberg -- References -- 11. Algorithms and the Changing Frontier by Hezekiah Agwara, Philip Auerswald, and Brian Higginbotham -- 11.1 Introduction -- 11.2 Changing Frontiers in the United States -- 11.3 Production Recipes, Standards, and Interoperability -- 11.4 Globalization Is Really Standardization -- 11.5 Using Quality Management Standards to Map the Movement of the Algorithmic Frontier -- 11.6 Algorithms and the Process of Discovery -- 11.7 Conclusion -- Appendix: ISO Management Standards (ISO 2012) -- References -- Comment by Timothy Simcoe -- Algorithmic Production -- Standards and Globalization -- Concluding Thoughts -- References -- Contributors -- Author Index -- Subject Index.
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  • 2
    Online Resource
    Online Resource
    Milton :CRC Press LLC,
    Keywords: Climatic changes-Mathematical models. ; Electronic books.
    Description / Table of Contents: Presents the topic of assessing and quantifying the climate change and its impacts from a multi-faceted perspective of ecosystem, human health, and social and infrastructure resilience, given through a lens of statistical and data sciences.
    Type of Medium: Online Resource
    Pages: 1 online resource (395 pages)
    Edition: 1st ed.
    ISBN: 9781351190824
    Series Statement: Chapman and Hall/CRC Applied Environmental Statistics Series
    DDC: 363.7387463
    Language: English
    Note: Cover -- Half Title -- Title Page -- Copyright Page -- Contents -- Preface -- Part I: Ecosystem Impacts -- 1. On Evaluation of Climate Models -- 1.1 Introduction -- 1.2 A brief tour of climate models -- 1.3 Evaluation of climate model outputs: summary measures -- 1.3.1 Simple summary measures -- 1.3.2 Evaluation by process isolation, instrument simulators, and initial value techniques -- 1.4 Ensemble-based approaches -- 1.4.1 Multimodel ensembles -- 1.4.2 Perturbation-parameter ensembles -- 1.4.3 Reliability ensemble averaging -- 1.4.4 Bayesian ensembles -- 1.4.5 Machine-learning ensemble approaches -- 1.5 Probabilistic model evaluation techniques -- 1.5.1 Model comparison by moving-block bootstrap -- 1.5.2 Evaluation using functional representations -- 1.6 Ensemble using empirical likelihood -- 1.7 Conclusions and future directions -- References -- 2. A Statistical Analysis of North Atlantic Tropical Cyclone Changes -- 2.1 Introduction -- 2.2 Data -- 2.3 Statistical methods -- 2.3.1 Penalized likelihood changepoint methods -- 2.3.2 Poisson counts -- 2.3.3 Correlated Gaussian data -- 2.4 Results -- 2.4.1 Total cyclone counts -- 2.4.2 Hurricanes and major storms -- 2.4.3 Analyses with segment-length restrictions -- 2.4.4 Accumulated cyclone energy -- 2.5 Comments and conclusions -- References -- 3. Fire-Weather Index and Climate Change -- 3.1 Introduction -- 3.2 Statistical modeling of the fire-weather index monthly maxima -- 3.2.1 Separate modeling -- 3.2.2 Spatial modeling -- 3.3 Summary and discussion -- References -- 4. Probabilistic Projections of High-Tide Flooding for the State of Maryland in the Twenty-First Century -- 4.1 Introduction -- 4.2 Methods -- 4.2.1 Regional ocean model -- 4.2.2 Design of numerical experiments -- 4.2.3 Inundation impact analysis -- 4.3 Results -- 4.3.1 Bay-wide response -- 4.3.2 Dorchester County. , 4.3.3 Annapolis and Baltimore -- 4.4 Conclusions -- References -- 5. Response of Benthic Biodiversity to Climate-Sensitive Regional and Local Conditions in a Complex Estuarine System -- 5.1 Introduction -- 5.2 Methods -- 5.2.1 Data sources -- 5.2.2 Biodiversity-climate modeling -- 5.3 Results -- 5.3.1 Benthic biodiversity patterns -- 5.3.2 Biodiversity-climate modeling results -- 5.3.3 Multivariate assemblage analysis -- 5.4 Discussion -- 5.4.1 Long-term trends in Chesapeake Bay benthic biodiversity -- 5.4.2 Climate drivers of benthic biodiversity -- 5.4.3 Regional climate outlook for Chesapeake Bay -- 5.4.4 Global outlook for estuarine communities in the face of climate forcing -- 5.5 Conclusions -- References -- 6. Using Structural Comparisons to Measure the Behavior of Complex Systems -- 6.1 Introduction -- 6.2 Data -- 6.3 Network alignment -- 6.4 Visualization -- 6.5 Example: the Chesapeake Bay -- 6.6 Critical considerations -- 6.7 Recipe -- 6.7.1 Ingredients -- 6.7.2 Step 1/3: Data -- 6.7.3 Step 2/3: Network alignment -- 6.7.4 Step 3/3: Visualization -- 6.8 Final thought -- References -- 7. Causality Analysis of Climate and Ecosystem Time Series -- 7.1 Introduction -- 7.2 Methods of causality detection -- 7.2.1 Granger causality -- 7.2.2 Nonlinear state space methods -- 7.2.3 Causal graphical models -- 7.3 Simulations -- 7.3.1 Simulated data -- 7.3.2 Arctic and the midlatitude jet stream -- 7.3.3 Sardine-anchovy and sea surface temperature -- 7.4 Conclusions -- References -- Part II: Socioeconomic Impacts -- 8. Statistical Issues in Detection of Trends in Losses from Extreme Weather and Climate Events -- 8.1 Introduction -- 8.2 Loss distribution -- 8.2.1 Overall distribution of losses -- 8.2.2 Distribution of extreme high losses -- 8.2.3 Reconciling implications for extremes -- 8.3 Bias, uncertainty, and variability in losses. , 8.3.1 Variability and uncertainty as sources of bias -- 8.3.2 Effects of adjustments -- 8.4 Detection and attribution of trends in losses -- 8.4.1 Random sum representation -- 8.4.2 Trend analyses -- 8.4.3 Issues in normalization of losses -- 8.5 Summary and discussion -- References -- 9. Event Attribution: Linking Specific Extreme Events to Human-Caused Climate Change -- 9.1 Why is this chapter in this book? -- 9.2 Background on event attribution -- 9.3 Event attribution methodologies -- 9.4 Impact attribution -- 9.5 FAR -- or "Not possible without climate change" -- 9.6 Communicating event attribution studies -- 9.7 Summary -- References -- 10. Financing Weather and Climate Risks in the United States -- 10.1 Disasters in the United States-the recent record -- 10.2 Climate and extremes -- 10.3 Assessing economic impacts -- 10.4 Insurance and risk financing -- 10.5 Data and analytical challenges -- 10.6 Implementation challenges -- 10.7 Financing mitigation and resilience -- 10.8 Pathways and conclusion -- References -- 11. Extreme Events, Population, and Risk: An Integrated Modeling Approach -- 11.1 Introduction -- 11.2 Conceptual framework for risk modeling -- 11.3 Applications of the conceptual framework -- 11.2.1 Hazard, exposure, vulnerability, and risk -- 11.3.1 An example considering hazard counts -- 11.3.2 An example considering hazard space-time fields -- 11.4 Discussion, conclusions, and future work -- References -- 12. Aspects of Climate-Induced Risk in Property Insurance -- 12.1 Introduction -- 12.2 The role of statistics in assessing insurance climate risk -- 12.3 Water damage to properties in Norway -- 12.4 The Gjensidige case study -- 12.4.1 Data -- 12.4.2 Modeling -- 12.4.3 Claim predictions -- 12.4.4 Extensions -- 12.5 Climate change and property insurance interactions -- 12.6 Conclusions -- References. , 13. Climate Change Impacts on the Nation's Electricity Sector -- 13.1 Introduction -- 13.2 Climate impacts and implications for the electricity sector -- 13.2.1 Specific extreme weather hazards and impacts to the electricity sector -- 13.3 Resilience approaches and options -- 13.4 Analytical approaches for assessing costs and benefits of resilience investments -- 13.4.1 Consolidated Edison of New York (Con Edison) case study: risk prioritization model -- 13.4.2 Public Service Electric & -- Gas (PSE& -- G) case study: break-even analysis -- 13.4.3 Entergy's case study: building a resilient Gulf Coast -- 13.5 Gaps and opportunities for improvement in resilience planning -- References -- 14. Impacts of Inclement Weather on Traffic Accidents in Mexico City -- 14.1 Introduction -- 14.2 Data description -- 14.3 Methods -- 14.4 Results -- 14.5 Conclusions -- References -- 15. Statistical Modeling of Dynamic Greenhouse Gas Emissions -- 15.1 Overview -- 15.2 Background -- 15.3 Introduction -- 15.4 Statistical framework -- 15.5 Ecosystem dynamical optimization -- 15.6 Numerical results -- 15.7 Summary -- 15.8 Appendix: model parameters and variables -- References -- 16. Agricultural Climate Risk Management and Global Food Security: Recent Progress in Southeast Asia -- 16.1 Climate risks management in agriculture-use of climate prediction in crop models -- 16.2 Current approaches integrating SCFs and crop simulation models applied in Southeast Asia -- 16.3 Examples of integrated SCF-crop modeling approach for climate risk management in Southeast Asia -- 16.3.1 The climate-agriculture-modeling and decision tool (CAMDT) -- 16.3.2 The integrated seasonal climate-crop yield forecasting system for robusta coffee (ICCFS-Robusta) -- 16.4 Challenges for operationalizing seasonal climate-crop modeling frameworks in Southeast Asia -- 16.4.1 Data scarcity. , 16.4.2 Assessing the skills of seasonal climate forecasts -- 16.4.3 Communicating SCF outputs to farmers -- 16.4.4 Extending the range of applications of integrated SCF-crop modeling systems -- 16.5 Improved climate risk management in Southeast Asia-the way forward -- References -- 17. Poppy Cultivation and Eradication in Mexico, 2000-2018: The Effects of Climate -- 17.1 Introduction -- 17.2 Context -- 17.3 Methodology -- 17.3.1 Overview of index construction -- 17.3.2 Statistical weighting of the index components, using the Shapley decomposition -- 17.3.3 Components of the poppy eradication index -- 17.4 Results -- 17.5 Discussion -- 17.6 Conclusions -- References -- Index.
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 76 (2001), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A large body of evidence suggests that an increase in the brain β-amyloid (Aβ) burden contributes to the etiology of Alzheimer's disease (AD). Much is now known about the intracellular processes regulating the production of Aβ, however, less is known regarding its secretion from cells. We now report that p-glycoprotein (p-gp), an ATP-binding cassette (ABC) transporter, is an Aβ efflux pump. Pharmacological blockade of p-gp rapidly decrease extracellular levels of Aβ secretion. In vitro binding studies showed that addition of synthetic human Aβ1–40 and Aβ1–42 peptides to hamster mdr1-enriched vesicles labeled with the fluorophore MIANS resulted in saturable quenching, suggesting that both peptides interact directly with the transporter. Finally, we were able to directly measure transport of Aβ peptides across the plasma membranes of p-gp enriched vesicles, and showed that this phenomenon was both ATP- and p-gp-dependent. Taken together, our study suggests a novel mechanism of Aβ detachment from cellular membranes, and represents an obvious route towards identification of such a mechanism in the brain.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 24 (1985), S. 0 
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : Stevens-Johnson syndrome is relatively rare. The authors report a retrospective study of 34 patients seen at the University Hospital in Malaysia over 16 years and discuss the epidemiology, clinical features, complications, investigations, etiologic association, mortality, sequelae, course of the disease, and the use of steroid.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 41 (2005), S. 0 
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: : Florida water resources are among the most abundant in the United States, with Florida receiving the second-highest mean annual rainfall of all states. However, water supply issues have troubled the state due to the highly variable spatial and temporal distributions of water supply and demand, and they are aggravated by the population's preference for settling in coastal regions where freshwater resources are scarce. Historically, the competing issues of water resource development and natural systems protection have placed water management agencies and local governments at odds. In 1997, the Florida Legislature enacted several major changes to Florida water law in an attempt to improve water resource planning and protection. This paper briefly reviews the history of water management in Florida with an emphasis on decisions culminating in the 1997 legislation, which requires the development of minimum flows and levels. Also examined is the impact of the 1997 law on water management. Efforts made to comply with legislative mandates are summarized; these include, to date, establishment of minimum flows and levels on 209 water bodies and budgeting in excess of $1.4 billion for water resource development projects.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 24 (1985), S. 0 
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Stevens-Johnson syndrome is relatively rare. The authors report a retrospective study of 34 patients seen at the University Hospital in Malaysia over 16 years and discuss the epidemiology, clinical features, complications, investigations, etiologic association, mortality, sequelae, course of the disease, and the use of steroid.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 19 (1998), S. 173-202 
    ISSN: 0163-7525
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Notes: Abstract Community-based research in public health focuses on social, structural, and physical environmental inequities through active involvement of community members, organizational representatives, and researchers in all aspects of the research process. Partners contribute their expertise to enhance understanding of a given phenomenon and to integrate the knowledge gained with action to benefit the community involved. This review provides a synthesis of key principles of community-based research, examines its place within the context of different scientific paradigms, discusses rationales for its use, and explores major challenges and facilitating factors and their implications for conducting effective community-based research aimed at improving the public's health.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: A three-dimensional digitizing method was used to assess the canopy structure of six Festuca arundinacea (FA)–Trifolium repens (TR) mixtures during the installation stage. Virtual canopy images were synthesized and used to derive light interception and partitioning between species. Computations from images were compared with a simple light model based on Beer’s law, in order to analyse within- and between-species foliage dispersion. The total leaf area index of the mixtures ranged from 0·6 to 4·5. The fraction of FA foliage overtopping TR was 9–30%. The mean inclination of FA and TR was 66 and 57°, respectively. Within-species dispersion parameters of FA and TR were about 0·8 and 1·0, namely clumped and random foliage dispersion, respectively. Although FA was sown in rows, between-species dispersion was random. Lower leaf inclination and lesser clumping in TR compensated foliage overtopping by FA, so that light partitioning between FA and TR (about 80 and 20%, respectively) was similar to the species contribution to total canopy foliage. Since between-species dispersion was random, a simple two-layer light model based on Beer’s law provided correct estimations of light partitioning (RMSE = 0·05), although light interception by FA was slightly overestimated because of its clumped dispersion.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The model RATP (radiation absorption, transpiration and photosynthesis) is presented. The model was designed to simulate the spatial distribution of radiation and leaf-gas exchanges within vegetation canopies as a function of canopy structure, canopy microclimate within the canopy and physical and physiological leaf properties. The model uses a three-dimensional (3D) representation of the canopy (i.e. an array of 3D cells, each characterized by a leaf area density). Radiation transfer is computed by a turbid medium analogy, transpiration by the leaf energy budget approach, and photosynthesis by the Farquhar model, each applied for sunlit and shaded leaves at the individual 3D cell-scale. The model typically operates at a 20–30 min time step. The RATP model was applied to an isolated, 20-year-old walnut tree grown in the field. The spatial distribution of wind speed, stomatal response to environmental variables, and light acclimation of leaf photosynthetic properties were taken into account. Model outputs were compared with data acquired in the field. The model was shown to simulate satisfactorily the intracrown distribution of radiation regime, transpiration and photosynthetic rates, at shoot or branch scales.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 25 (1998), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Troy and Ackerman defined the term sebaceoma (Am J Dermatopathol 1984: 6: 7-13) as benign neoplasm of basaloid cells with varying numbers of mature sebocytes. Steffen and Ackerman (Neoplasms with sebaceous differentiation. Philadelphia: Lee and Febiger, 1994: 401-425) illustrated many examples of sebaceoma, two of which had a reticulated and cribriform pattern. We report a case of sebaceoma from the scalp of a 52-year-old white female. Histologically, it displayed reticulated and cribriform basaloid epithelial islands. This is the third reported case of sebaceoma, to our knowledge, with these unusual features.
    Type of Medium: Electronic Resource
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