ISSN:
1432-2277
Keywords:
Key words Kidney transplantation
;
HLA-DR mismatches
;
Wujciak-Opelz allocation system
;
Wujciak-Opelz allocation system
;
HLA mismatches
;
kidney transplantation
;
HLA mismatches
;
Wujciak-Opelz allocation system
;
kidney transplantation
;
Acute rejection
;
kidney transplantation
;
Wujciak-Opelz allocation system
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The present single-center, retrospective study was undertaken to assess the impact of the Wujciak-Opelz allocation system (XCOMB), currently used within Eurotransplant for renal allografts, on the incidence of early occurring rejection episodes (RE). Implementation of the system resulted in an increase of HLA-DR mismatches (MM), while the incidence of HLA-A + B + DR MM remained unchanged. During the 1st post-transplant month, the total number of RE, expressed per patient-months, increased by 64 % (0.326 vs 0.199, P = 0.007); when considering only severe and irreversible RE, the increase was 76 % (0.158 vs 0.090, P = 0.011). In contrast, from the 2nd to the 12th post-transplant month, the incidence of RE, regardless of severity, was similar before and after implementation of XCOMB. As early occurring RE have detrimental effects on long-term graft outcome, these observations, if confirmed on a larger scale, would justify changes in the allocation algorithm.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001470050161
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