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  • 1
    Electronic Resource
    Electronic Resource
    CD5+B in Rheumatoid Arthritis (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 651 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb24660.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Affinity Maturation and Isotype Switch in Clonally Related Anti-Erythrocyte Autoantibodies (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 40 (1994), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The NZB mouse is genetically predisposed to develop, at approximately 6 months of age, a spontaneous and severe autoimmune anaemia caused by production of pathogenic anti-mouse erythrocyte auto-antibodies. Molecular analysis of a panel of five anti-erythrocyte monoclonal antibodies (MoAb) derived from splenocytes of unimmunized NZB mice revealed that these autoantibodies all had functionally rearranged genes from the VH J558 family of immunoglobulin genes with closest homology to germline genes H10 and H30. Owing to clustering of nucleotide differences within the CDRs, compared with the germline, it was concluded that these antibodies were most likely generated by an antigen-driven mechanism.We report here further molecular analysis of two (4.16.1 and B4.13.2) of the panel of five anti-mouse erythrocyte producing hybridomas which are apparently clonally related. Nucleotide analysis of the light chain cDNA indicated that both antibodies had closest homology to germline gene Vk24 and use Jk2 gene. Determination of the functional affinities of the MoAb reveal that B4.13.2 (IgG2a) has a 〉 10-fold higher affinity for mouse erythrocytes when compared to 4.16.1 (IgGl). This finding supports the view that these two autoantibodies are generated by an antigen-driven mechanism. The proposed mechanism would involve the selection and expansion of a small population of B-lymphocytes by antigen leading to isotype switch, somatic mutation and increased affinity. Our data also point to the possibility that some framework residues may be involved in the binding to antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1994.tb03427.x
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  • 3
    Electronic Resource
    Electronic Resource
    Post-conditioning with lipopolysaccharide reduces the inflammatory infiltrate to the injured brain and spinal cord: a potential neuroprotective treatment (2005)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 22 (2005), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Systemic infection often accompanies or precedes acute brain injury, but it remains unclear how the systemic response contributes to outcome. To examine this problem we have microinjected recombinant interleukin-1beta (IL-1β), a cytokine associated with acute brain injury, into the rat brain parenchyma and either preceded or followed this challenge with the intravenous injection of lipopolysaccharide (LPS), which mimics systemic inflammatory response syndrome. The microinjection of IL-1β alone into the brain parenchyma gives rise to leukocyte mobilization in the blood, and to the delayed recruitment of neutrophils and monocytes to the brain with no evidence of blood–brain barrier breakdown or overt neuronal cell death. Systemic LPS pre-conditioning resulted in a dose-dependent reduction both in the number of circulating leukocytes and in the number of leukocytes recruited to the brain parenchyma after 12 h. Surprisingly, LPS given two hours after injury was equally effective in reducing the recruitment of leukocytes to the brain, which is more relevant to the management of clinical disease. In a more clinically relevant model of spinal cord injury, intravenous LPS post-conditioning also reduced the numbers of leukocytes mobilized in the blood and recruited to the spinal cord and thus limited the breakdown of the blood–spinal cord barrier. The effects appear to be specific to LPS, as they were not observed after intravenous IL-1β pre-conditioning. Our studies suggest that individual pro-inflammatory conditioning strategies may protect the injured central nervous system from the damaging consequences of leukocyte recruitment and may provide scope for novel therapeutic intervention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.2005.04447.x
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  • 4
    Electronic Resource
    Electronic Resource
    SEISMIC SOURCES FOR SHALLOW REFLECTION SURVEYING (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 33 (1985), S. 0 
    Details
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: A standard seismic reflection profile was shot along a disused railway track at Onley, near Rugby, U. K. Four different seismic sources including explosives, the propane/oxygen gas-gun, the Bolt airgun, and the borehole sparker were used and compared with each other in terms of output energy, penetration and resolution. The results indicated that the resolution of the borehole airgun and the gas-gun was slightly higher than that possible with gelignite. Both these sources had an output energy which was equivalent to 30 g of gelignite.The borehole sparker was only useful for obtaining seismic information on the nearsurface weathered layer, since its output power (1 kJ) was very limited. However, McCann and McCann (1982) used a high-power sparker source (14 kJ) on the nearby Grand Union Canal for a wide angle seismic reflection survey and achieved a maximum penetration of 250 m, which is comparable with the results obtained on land with the seismic sources mentioned above.The seismic reflection profile, which was interpreted in the light of borehole information in the area and the results of McCann and McCann (1982), successfully identified the surface of the Palaeozoic rocks. The problem of detecting the presence of thin, high-velocity layers in a seismic refraction survey without the availability of other information to calibrate the seismic section is also highlighted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2478.1985.tb00790.x
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  • 5
    Electronic Resource
    Electronic Resource
    A deep seismic reflection profile over a Caledonian granite in central England (1982)
    [s.l.] : Nature Publishing Group
    Nature 297 (1982), S. 671-673 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The various granitic rocks of Leicestershire observed at Mountsorrel, Countesthorpe, Croft, Enderby, Stoney Stanton and in the recent NCB borehole at Kirby Lane, south-west of Melton Mowbray (Fig. 1) are considered to be the surface expression of a large calc-alkaline granitic pluton1'2. These ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/297671a0
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