Publication Date:
2012-01-17
Description:
Recognition and clearance of a bacterial infection are a fundamental properties of innate immunity. Here, we describe an effector B cell population that protects against microbial sepsis. Innate response activator (IRA) B cells are phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Specific deletion of IRA B cell activity impairs bacterial clearance, elicits a cytokine storm, and precipitates septic shock. These observations enrich our understanding of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new treatment avenues for infectious diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279743/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279743/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rauch, Philipp J -- Chudnovskiy, Aleksey -- Robbins, Clinton S -- Weber, Georg F -- Etzrodt, Martin -- Hilgendorf, Ingo -- Tiglao, Elizabeth -- Figueiredo, Jose-Luiz -- Iwamoto, Yoshiko -- Theurl, Igor -- Gorbatov, Rostic -- Waring, Michael T -- Chicoine, Adam T -- Mouded, Majd -- Pittet, Mikael J -- Nahrendorf, Matthias -- Weissleder, Ralph -- Swirski, Filip K -- 1R01HL095612/HL/NHLBI NIH HHS/ -- P01-A154904/PHS HHS/ -- P50 CA086355/CA/NCI NIH HHS/ -- P50 CA086355-11/CA/NCI NIH HHS/ -- P50 CA86355/CA/NCI NIH HHS/ -- R01 HL095612/HL/NHLBI NIH HHS/ -- R01 HL095612-03/HL/NHLBI NIH HHS/ -- R24 CA69246/CA/NCI NIH HHS/ -- S10 RR026360/RR/NCRR NIH HHS/ -- U01 HL080731/HL/NHLBI NIH HHS/ -- U01 HL080731-04/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2012 Feb 3;335(6068):597-601. doi: 10.1126/science.1215173. Epub 2012 Jan 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22245738" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
B-Lymphocyte Subsets/*immunology/metabolism
;
Cell Lineage
;
Cell Separation
;
Escherichia coli Infections/*immunology
;
Female
;
Flow Cytometry
;
Granulocyte-Macrophage Colony-Stimulating Factor/immunology/*metabolism
;
*Immunity, Innate
;
Immunoglobulin M/metabolism
;
Immunophenotyping
;
Integrin alpha4beta1/immunology/metabolism
;
Lipopolysaccharides
;
Lymphocyte Activation
;
Lymphocyte Function-Associated Antigen-1/immunology/metabolism
;
Mice
;
Mice, Inbred C57BL
;
Parabiosis
;
Peritonitis/*immunology
;
Sepsis/*immunology
;
Shock, Septic/immunology
;
Spleen/immunology
;
Toll-Like Receptor 4/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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