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  • 1
    Electronic Resource
    Electronic Resource
    Limited T Helper Cell Activity in C57BL/10 (B10) Mice with Inherited Low IgG Responsiveness (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 44 (1996), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Due to limitations in antigen processing, mice of the C57BL/10ScSn (B10) strain exhibit a low IgG production against a variety of T-dependent antigens. To characterize the T-cell functions, the authors studied antigen-specific T-cell proliferation and cytokine production in vitro. The response of B10 mice was compared with that of the high IgG producing strain A/J. A highly restricted proliferative response and almost no interleukin-2 (IL-2) and interleukin-3 (IL-3) production was detected in lymph node (LN) cells of B10 mice primed in vivo by protein antigens and subjected to a specific restimulation in vitro, whilst A/J cells responded by significant proliferation and cytokine production. The antigen-specific T-cell response of B10 mice could not be increased by lipopolysaccharide treatment in vivo or by in vitro cultivation with IL-2. However, the T cells of B10 mice produced high levels of IL-2 and IL-4 when stimulated by phorbol myristate acetate (PMA) and Ca2+ ionophore, proving the existence of a functionally intact signal transduction pathway downstream of protein kinase C (PKC). The results suggest that the in vivo antigen priming does not effectively activate the T cells in B10 mice. The limited activation consequently leads to the low IgG response described in B10 mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1996.d01-337.x
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  • 2
    Electronic Resource
    Electronic Resource
    Characteristics of γ-Globulin, lacking Antibody Properties, in New-born Pigs (1961)
    [s.l.] : Nature Publishing Group
    Nature 189 (1961), S. 1020-1022 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the present communication the results of physico-chemical and immunochemical investigations of y-globulin of piglets which were bled shortly after birth without the intake of colostrum are presented. The y-globulin was isolated from the serum by twice-repeated preparative electrophoresis on a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1891020a0
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  • 3
    Electronic Resource
    Electronic Resource
    A Localized Haemolysis in Gel Method for the Detection of Cells Producing 7 S Antibody: Detection of Cells producing 7 S Antibodies by the Plaque Technique   (1965)
    [s.l.] : Nature Publishing Group
    Nature 208 (1965), S. 858-859 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE kinetics of the appearance of antibody-forming 1 cells after the injection of sheep red blood cell (sheep-RBC) antigen have been studied by the plaque technique1'2. The number of plaque-forming cells before immunization is about 60 per 108 lymphoid cells; but after immunization the number rises ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/208858a0
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  • 4
    Electronic Resource
    Electronic Resource
    Antibody Formation by Isolated Spleen Cells transferred to Recipients in Absence of Homotransplantation Reaction (1959)
    [s.l.] : Nature Publishing Group
    Nature 183 (1959), S. 546-547 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Normal White Leghorns weighing 1 -5-2 kgm. were used as donors of spleen cells, which were isolated as described in a previous report4. Spleen cells mixed with antigen in vitro were transferred either by intra-peritoneal route to chickens 2 days after hatching or into the chorioallantoic vein of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/183546a0
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  • 5
    Electronic Resource
    Electronic Resource
    Experimental immune complex glomerulopathy: Immunomorphological aspects and correlations with human disease (1975)
    Springer
    International urology and nephrology 7 (1975), S. 219-233 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirteen rabbits received parenteral injections of human serum albumin (HSA) in regular doses and intervals during 6–32 weeks. The antigen load elicited immune responses of variable degree, giving a good correlation with the extent and quality of immune complex (IMC) deposition, as shown by immunological methods, electron and fluorescence microscopy and by histoautoradiography. Morphology of immune deposits (IMD) depended on the composition of the IMC and produced a continuous scale of glomerular involvement, ranging from minimal and focal to massive and diffuse deposition. Probable rudimentary traces of IMD were apparent in the ultrastructure even in animals with negative results of both immunological and immunfluorescence examinations. The relationships are discussed between experimental IMC-induced glomerulopathy on the one hand, and some problems of development and bioptic evaluation of human glomerulonephritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02082678
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