Schlagwort(e):
Microfluidics.
;
Nanofluids.
;
Electronic books.
Beschreibung / Inhaltsverzeichnis:
This book explains the principle and the important application potential of micro-segmented flow. It introduces brand-new microfluidic approaches for generating high-quality nanomaterials and presents droplet-based techniques for biological screenings.
Materialart:
Online-Ressource
Seiten:
1 online resource (284 pages)
Ausgabe:
1st ed.
ISBN:
9783642387807
Serie:
Biological and Medical Physics, Biomedical Engineering Series
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=1592071
DDC:
620.5
Sprache:
Englisch
Anmerkung:
Intro -- Preface -- Contents -- Contributors -- Variables -- 1 Introduction -- 1.1 Micro Segmented Flow: A Challenging and Very Promising Strategy of Microfluidics -- Part IGeneration, Manipulation and Characterization of Micro Fluid Segments -- 2 Droplet Microfluidics in Two-Dimensional Channels -- 2.1 Droplets in Linear Channels and on Two-Dimensional Surfaces -- 2.2 Generating Droplet Arrays in Microchannels -- 2.3 Using Surface Energy Gradients for Droplet Manipulation -- 2.4 Rails and Anchors -- 2.4.1 Principle of Droplet Anchors -- 2.4.2 The Anchor Strength -- 2.4.3 Parking Versus Buffering Modes -- 2.4.4 Forces Due to External Fields -- 2.5 Making and Manipulating Two-Dimensional Arrays -- 2.6 Active Manipulation in Two-Dimensional Geometries -- 2.6.1 Actuation by Laser Beams -- 2.6.2 Removing a Drop From an Anchor -- 2.6.3 Selectively Filling an Array -- 2.6.4 Initiating a Chemical Reaction on Demand by Laser-Controlled Droplet Fusion -- 2.7 Using Surface Energy Gradients Without a Mean Flow -- 2.8 Summary and Conclusions on Droplet Manipulation by Surface Forces -- References -- 3 Electrical Switching of Droplets and Fluid Segments -- 3.1 Introduction on Electrical Switching of Droplets -- 3.2 Droplets and Segments -- 3.2.1 Droplets -- 3.2.2 Micro Fluid Segments and Their Manipulation Without Electrical Actuation -- 3.3 Electrostatic Manipulation of Droplets in a Liquid Carrier -- 3.3.1 Droplet Charging -- 3.3.2 Actuation of Droplets by Static Electrical Fields -- 3.3.3 Droplet Sorting by Electrostatic Electrical Manipulation -- 3.4 Dielectric Manipulation of Droplets by Alternating Fields in a Liquid Carrier -- 3.4.1 Trapping of Droplets in Field Cages -- 3.4.2 Dielectric Actuation of Droplets by Dielectrophoresis -- 3.5 Manipulation of Fluid Segments by Potential Switching.
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3.6 Applications and Challenges for Electrical Switching of Droplets and Segments -- References -- 4 Chip-Integrated Solutions for Manipulation and Sorting of Micro Droplets and Fluid Segments by Electrical Actuation -- 4.1 Basics for Chip Integration of Droplet Actuators -- 4.1.1 Continuous Flow Analysis (CFA) -- 4.1.2 Digital Microfluidics (DMF) -- 4.1.3 Labs on a Chip (LoC) and Micro Total Analysis Systems (μTAS) -- 4.1.4 Combining CFA Systems with DMF Concepts -- 4.2 Modeling and Simulation for Electrostatic Actuation in Integrated Devices -- 4.2.1 General Aspects of Modeling of Electrostatic Actuation -- 4.2.2 Modeling of Electrostatic Actuators -- 4.2.3 Electrostatic Forces in Relation to Flow Forces -- 4.3 Technology Considerations and Fabrication of Chip Devices for Electrostatic Actuation -- 4.3.1 Materials and Basic Concept -- 4.3.2 Technology Concept and Manufacturing -- 4.4 Experimental Realization of Chip-Integrated Electrostatic Actuators -- 4.5 Summarizing Conclusions on Modeling, Realization and Application Potential of Chip-Integrated Electrostatic Actuation of Micro Fluid Segments -- References -- 5 Electrical Sensing in Segmented Flow Microfluidics -- 5.1 Introduction in to Electrical Sensing of Droplets and Micro Fluid Segments -- 5.2 Capacitive Sensing of Droplets -- 5.2.1 Principle of Capacitive Sensing -- 5.2.2 Experimental Example of Capacitive Measurements in Microfluid Segments Embedded in a Perfluorinated Carrier Liquid -- 5.3 Impedimetric Measurement of Conductivity in Segmented Flow -- 5.3.1 Impedimetric Measurement Principle -- 5.3.2 Finite Element Model of Non-Contact Impedance Measurement -- 5.3.3 Analytical Model of Non-Contact Impedance Measurement -- 5.4 Experimental Investigation of an Inline Noncontact Impedance Measurement Sensor -- 5.4.1 Impedance Measurement of Ionic Strength.
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5.4.2 Measurement of Droplets -- 5.5 Microwave Sensing in Micro Fluidic Segmented Flow -- 5.5.1 Principle of Microwave Sensing in Microfluidics -- 5.5.2 Example of Experimental Realization if Microwave Sensing in Microsegmented Flow -- 5.6 Summarizing Conclusions for Electrical Characterization in Microsegmented Flow -- References -- Part IIChemical Application in Micro Continuous-Flow Synthesis of Nanoparticles -- 6 Solid Particle Handling in Microreaction Technology: Practical Challenges and Application of Microfluid Segments for Particle-Based Processes -- 6.1 Application of Solids in Microfluidics -- 6.2 Particle Transport Behavior in Micro Segmented Flow -- 6.3 Feeding of Particles and Suspensions in Microsegmented Flow -- 6.4 Clogging Risk and Clogging Prevention -- 6.5 Downstream Phase Separation -- 6.5.1 General Aspects of Separation in Micro Segmented Flow -- 6.5.2 Micro Settlers -- 6.5.3 Micro-Hydrocyclones and Curved Branches -- 6.5.4 Wettability and Capillarity Separators: Membranes, Pore Combs, Branches -- 6.6 Heterogeneously Catalyzed Reactions in Microfluidic Processes -- 6.6.1 Application of Suspension Slug Flow for Heterogeneously Catalyzed Reactions -- 6.6.2 Micro-Packed Bed -- 6.6.3 Suspension Slug Flow Microreactor -- 6.6.4 Wall-Coated Microreactor -- 6.6.5 Membrane/Mesh Microreactor -- 6.7 Conclusion on Particle Handling and Synthesis in Micro Segmented Flow -- References -- 7 Micro Continuous-Flow Synthesis of Metal Nanoparticles Using Micro Fluid Segment Technology -- 7.1 Introduction in Metal Nanoparticle Synthesis by Micro Fluid Segment Technique -- 7.2 Requirements of the Synthesis of Metal Nanoparticles and the Specific Advantages of Micro Fluid Segment Technique Therefore -- 7.3 General Aspects of Particle Formation and Partial Processes of Noble Metal Nanoparticle Synthesis.
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7.4 Addressing of Size and Shape in a Micro Segmented Flow-Through Metal Nanoparticle Synthesis -- 7.5 Micro Segmented Flow Synthesis of Composed Metal Nanoparticles -- 7.6 Automated Synthesis Experiments in Large Parameter Spaces for a Variation of the Plasmonic Properties of Nanoparticles by Varied Reactant Composition in Fluid Segment Sequences -- 7.7 Conclusion and Outlook on Metal Nanoparticle Formation in Micro Segmented Flow -- References -- Part IIIBiological Application: Cell-Free Biotechnology, Cell Cultivation and Screening Systems -- 8 Characterization of Combinatorial Effects of Toxic Substances by Cell Cultivation in Micro Segmented Flow -- 8.1 Introduction: Miniaturized Techniques for Biomedical, Pharmaceutical, Food and Environmental Toxicology -- 8.2 Advantages of Micro Segmented Flow for Miniaturized Cellular Screenings -- 8.3 Miniaturized Determination of Highly Resolved Dose/Response Functions -- 8.4 Strategy and Set-Up for Generation of 2D- and 3D-Concentration Programs -- 8.5 Determination of Combinatorial Effects by Characterization of Dose/Response Functions in Two-Dimensional Concentration Spaces -- 8.6 Multi-Endpoint Detection under Microfluidic Conditions -- 8.7 Interferences Between Food Components, Nanoparticles and Antibiotics -- 8.8 Application of Micro Fluid Segments for Studying Toxic Effects on Multicellular Organisms -- 8.9 Potential of the Segmented Flow Technique for Toxicology and Further Challenges -- References -- 9 Screening for Antibiotic Activity by Miniaturized Cultivation in Micro-Segmented Flow -- 9.1 Introduction: Antibiotics and Antimicrobial Resistance -- 9.2 Current State of Screening for New Antimicrobial Products -- 9.3 Microbial Assays in Droplet-Based Microfluidic Systems and in Micro-Segmented Flow -- 9.3.1 General Considerations for Microbial Assays in Droplet-Based Systems.
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9.3.2 Culture Media for Droplet-Based Screening -- 9.3.3 Detection Mechanisms for Droplet-Based Screening -- 9.3.4 Reporter Organisms for Droplet-Based Screening -- 9.3.5 Aspects of Co-cultivation of Different Microbial Species -- 9.4 Detection of Antibiotic Activity in Droplets and Screening for Novel Antibiotics -- 9.4.1 Possibilities and Constraints of Antibiotic Screening in Droplets -- 9.4.2 Screening for Novel Antibiotics in Micro-Segmented Flow -- 9.4.3 Improving Robustness of Screening in Micro-Segmented Flow -- 9.5 Emulsion-Based Microfluidic Screenings: An Overview -- 9.5.1 Droplet Generation and Handling for Highly Parallelized Operations -- 9.5.2 Screening for Novel Antibiotics with an Emulsion-Based Microfludic Approach -- 9.6 Summary and Outlook on Antimicrobial Screenings in Micro-Segmented Flow and Emulsion-Based Systems -- References -- Index.
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