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  • 1
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    Online Resource
    Whole-Body Magnetic Resonance Imaging in the Large Population-Based German National Cohort Study : Predictive Capability of Automated Image Quality Assessment for Protocol Repetitions
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Investigative Radiology Vol. 57, No. 7 ( 2022-7), p. 478-487
    Details
    In: Investigative Radiology, Ovid Technologies (Wolters Kluwer Health), Vol. 57, No. 7 ( 2022-7), p. 478-487
    Abstract: Reproducible image quality is of high relevance for large cohort studies and can be challenging for magnetic resonance imaging (MRI). Automated image quality assessment may contribute to conducting radiologic studies effectively. Purpose The aims of this study were to assess protocol repetition frequency in population-based whole-body MRI along with its effect on examination time and to examine the applicability of automated image quality assessment for predicting decision-making regarding repeated acquisitions. Materials and Methods All participants enrolled in the prospective, multicenter German National Cohort (NAKO) study who underwent whole-body MRI at 1 of 5 sites from 2014 to 2016 were included in this analysis (n = 11,347). A standardized examination program of 12 protocols was used. Acquisitions were carried out by certified radiologic technologists, who were authorized to repeat protocols based on their visual perception of image quality. Eleven image quality parameters were derived fully automatically from the acquired images, and their discrimination ability regarding baseline acquisitions and repetitions was tested. Results At least 1 protocol was repeated in 12% (n = 1359) of participants, and more than 1 protocol in 1.6% (n = 181). The repetition frequency differed across protocols ( P 〈 0.001), imaging sites ( P 〈 0.001), and over the study period ( P 〈 0.001). The mean total scan time was 62.6 minutes in participants without and 67.4 minutes in participants with protocol repetitions (mean difference, 4.8 minutes; 95% confidence interval, 4.5–5.2 minutes). Ten of the automatically derived image quality parameters were individually retrospectively predictive for the repetition of particular protocols; for instance, “signal-to-noise ratio” alone provided an area under the curve of 0.65 ( P 〈 0.001) for repetition of the Cardio Cine SSFP SAX protocol. Combinations generally improved prediction ability, as exemplified by “image sharpness” plus “foreground ratio” yielding an area under the curve of 0.89 ( P 〈 0.001) for repetition of the Neuro T1w 3D MPRAGE protocol, versus 0.85 ( P 〈 0.001) and 0.68 ( P 〈 0.001) as individual parameters. Conclusions Magnetic resonance imaging protocol repetitions were necessary in approximately 12% of scans even in the highly standardized setting of a large cohort study. Automated image quality assessment shows predictive value for the technologists' decision to perform protocol repetitions and has the potential to improve imaging efficiency.
    Type of Medium: Online Resource
    ISSN: 1536-0210 , 0020-9996
    URL: Article
    DOI: 10.1097/RLI.0000000000000861
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2041543-6
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  • 2
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    Distribution and Associated Factors of Hepatic Iron—A Population-Based Imaging Study
    MDPI AG ; 2021
    In:  Metabolites Vol. 11, No. 12 ( 2021-12-15), p. 871-
    Details
    In: Metabolites, MDPI AG, Vol. 11, No. 12 ( 2021-12-15), p. 871-
    Abstract: Hepatic iron overload can cause severe organ damage; therefore, an early diagnosis and the identification of potential risk factors is crucial. We aimed to investigate the sex-specific distribution of hepatic iron content (HIC) in a population-based cohort and identify relevant associated factors from a panel of markers. We analyzed N = 353 participants from a cross-sectional sample (KORA FF4) who underwent whole-body magnetic resonance imaging. HIC was assessed by single-voxel spectroscopy with a high-speed T2-corrected multi-echo technique. A large panel of markers, including anthropometric, genetic, and laboratory values, as well as behavioral risk factors were assessed. Relevant factors associated with HIC were identified by variable selection based on LASSO regression with bootstrap resampling. HIC in the study sample (mean age at examination: 56.0 years, 58.4% men) was significantly lower in women (mean ± SD: 39.2 ± 4.1 s−1) than in men (41.8 ± 4.7 s−1, p 〈 0.001). Relevant factors associated with HIC were HbA1c as well as prediabetes for men and visceral adipose tissue as well as age for women. Hepatic fat, alcohol consumption, and genetic risk score for iron levels were associated with HIC in both sexes. In conclusion, there are sex-specific associations of HIC with markers of body composition, glucose metabolism, and alcohol consumption.
    Type of Medium: Online Resource
    ISSN: 2218-1989
    URL: Article
    DOI: 10.3390/metabo11120871
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2662251-8
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  • 3
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    Dietary habits and the presence and degree of asymptomatic diverticular disease by magnetic resonance imaging in a Western population: a population-based cohort study
    Springer Science and Business Media LLC ; 2021
    In:  Nutrition & Metabolism Vol. 18, No. 1 ( 2021-12)
    Details
    In: Nutrition & Metabolism, Springer Science and Business Media LLC, Vol. 18, No. 1 ( 2021-12)
    Abstract: Despite the worldwide burden of diverticular disease, the connections between diverticular disease and dietary habits remain poorly understood, particularly in an asymptomatic representative sample. We investigated the association between asymptomatic diverticular disease as assessed by magnetic resonance imaging (MRI) and dietary habits in a Western study cohort. Methods Participants from a cross-sectional sample of a population-based cohort study underwent whole-body 3T-MRI including an isotropic VIBE-Dixon sequence. The presence and extent of diverticular disease was assessed in blinded fashion. Habitual dietary intake was recorded using a blended approach, applying 24-h food lists and a food-frequency questionnaire. Traditional cardiometabolic risk factors were obtained by interviews and medical examination. Univariate and multivariate associations were calculated. Results A total of 308 subjects were included in this analysis (56% male, 56.4 ± 9.1 years). 39.9% had any form of diverticular disease and 15.3% had advanced asymptomatic diverticular disease. After adjustment for age, sex and total energy intake a higher intake of fiber and vegetables was associated with a lower odds for asymptomatic diverticular disease (fiber: OR 0.68 95% CI [0.48, 0.95]; vegetables: OR 0.72 95% CI [0.53, 0.97] ) and an increased intake of meat was associated with an approximately two-fold higher odds for advanced asymptomatic diverticular disease (OR 1.84 95% CI [1.13, 2.99]). However, after additional adjustment for body-mass-index (BMI), alcohol consumption, smoking behavior and physical activity only a high fiber and vegetables intake remained significantly associated with lower odds of asymptomatic diverticular disease. Conclusion Our results indicate that a high-fiber diet and increased intake of vegetables is associated with lower odds of having asymptomatic diverticular disease, independent of age, sex, total energy intake, BMI and other life-style factors.
    Type of Medium: Online Resource
    ISSN: 1743-7075
    URL: Article
    DOI: 10.1186/s12986-021-00599-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2160376-5
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  • 4
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    Automated MR-based lung volume segmentation in population-based whole-body MR imaging: correlation with clinical characteristics, pulmonary function testing and obstructive lung disease
    Springer Science and Business Media LLC ; 2019
    In:  European Radiology Vol. 29, No. 3 ( 2019-3), p. 1595-1606
    Details
    In: European Radiology, Springer Science and Business Media LLC, Vol. 29, No. 3 ( 2019-3), p. 1595-1606
    Type of Medium: Online Resource
    ISSN: 0938-7994 , 1432-1084
    URL: Article
    DOI: 10.1007/s00330-018-5659-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 1472718-3
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  • 5
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    Association between Adipose Tissue Depots and Dyslipidemia: The KORA-MRI Population-Based Study
    MDPI AG ; 2022
    In:  Nutrients Vol. 14, No. 4 ( 2022-02-14), p. 797-
    Details
    In: Nutrients, MDPI AG, Vol. 14, No. 4 ( 2022-02-14), p. 797-
    Abstract: Obesity increases the risk of cardiovascular diseases (CVD), however, whether adipose tissue relates to dyslipidemia, and consequently to cardiovascular events remains unknown. Thus, we investigated the association of adipose tissue with circulating lipoproteins and triglycerides (TG) in subjects without CVD. 384 participants from the KORA-MRI study (mean age 56.2 ± 9.2 years; 41.9% female) underwent whole-body 3T-MRI. Visceral (VAT) and subcutaneous adipose tissue (SAT) derived from T1-DIXON-sequence using a semi-automatic algorithm. Total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and TG were measured. Linear regression was applied to examine the relationships between adipose tissue, circulating lipoproteins, and TG, adjusting for risk factors. VAT was associated with total cholesterol (per SD increase) (ß = 0.39, p 〈 0.001). Total adipose tissue (TAT) and VAT were inversely associated with HDL (ß = −0.09, p = 0.009; ß = −0.14, p 〈 0.001), and positively associated with LDL (ß = 0.32, p 〈 0.001; ß = 0.37, p 〈 0.001). All adipose tissues were associated with TG (ß = 0.20, p 〈 0.001; ß = 0.27, p 〈 0.001; ß = 0.11, p = 0.004). Stratified analysis by sex and body mass index (BMI) was confirmatory in women and in individuals with BMI 〈 30. Our results suggest that adipose tissue plays an important role in increasing CVD risk independent of BMI, whereas gender imbalance may be explained by accurate characterization and quantification of adipose tissue.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu14040797
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518386-2
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  • 6
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    Adipose tissue is associated with kidney function parameters
    Springer Science and Business Media LLC ; 2023
    In:  Scientific Reports Vol. 13, No. 1 ( 2023-06-06)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-06-06)
    Abstract: Obesity is characterized by the accumulation of adipose tissue in different body compartments. Whether adipose tissue directly affects kidney function is still unknown. We aimed to investigate the role of the adipose tissue and circulating creatinine, cystatin C and kidney function in subjects free of cardio-renal diseases. In the KORA-MRI population-based study, 377 subjects (mean age 56.2 ± 9.2 years; 41.6% female) underwent whole-body 3T-MRI examination. Adipose tissue defined as visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were quantified from T1-DIXON sequence using a semi-automatic algorithm. Serum creatinine and cystatin C were measured using standard laboratory and estimated glomerular filtration rate (e-GFR) was performed based on creatinine (e-GFR crea ), cystatin C (e-GFR cys ) and creatinine-cystatin C (e-GFR cc ). Linear regression analysis, adjusted for risk factors, was used to investigate the relationship between adipose tissue and circulating creatinine, cystatin C, and kidney function. In multivariate analyses VAT was inversely associated with eGFR cys (ß = − 4.88, p  =   〈  0.001), and positively associated with serum cystatin C (ß = 0.05, p  =   〈  0.001), respectively. No association was found between other adipose parameters such as total adipose tissue (TAT) and subcutaneous adipose tissue (SAT) and serum creatinine, urine microalbumin and eGFR crea . Stratified analyses according to BMI revealed confirmatory results for category of BMI  〉  30. VAT is positively associated with serum cystatin C and inversely with eGFR based on cystatin C, suggesting a direct involvement of visceral adipose tissue in increased metabolism of cystatin C and consequently decreased kidney function.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-023-36390-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2615211-3
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  • 7
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    Interventional Management of Vascular Complications after Renal Transplantation
    Georg Thieme Verlag KG ; 2023
    In:  RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren Vol. 195, No. 06 ( 2023-06), p. 495-504
    Details
    In: RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, Georg Thieme Verlag KG, Vol. 195, No. 06 ( 2023-06), p. 495-504
    Abstract: Hintergrund Nierentransplantationen nehmen aufgrund des demografischen Wandels zu und sind die Behandlung der Wahl bei Nierenerkrankungen im Endstadium. Dabei kann es in der Frühphase nach Transplantation, aber auch im späteren Verlauf zu Komplikationen im Bereich der Transplantatgefäße sowie des Ureters kommen. Postoperative Komplikationen treten bei etwa 12 % bis 25 % der Patienten mit Nierentransplantation auf. In diesen Fällen sind minimalinvasive therapeutische Maßnahmen entscheidend, um die Transplantatfunktion dauerhaft sicherzustellen. Ungeachtet der nicht vaskulären Komplikationen thematisiert dieser Übersichtsartikel die wichtigsten Komplikationen des Gefäßsystems nach erfolgter Nierentransplantation und erörtert aktuelle Empfehlungen zur interventionellen Behandlung. Methode Es wurde eine selektive Literaturrecherche in PubMed mit den Suchbegriffen „kidney transplantation“, „complications“ und „interventional treatment“ durchgeführt. Darüber hinaus wurden der Jahresbericht 2022 der Deutschen Stiftung Organspende sowie die aktuellen Leitlinien der Nierentransplantation der EAU (European Association of Urology) berücksichtigt. Ergebnisse und Schlussfolgerung Interventionelle Therapietechniken sind im Vergleich zur operativen Revision minimalinvasiv und sollten für vaskuläre Komplikationen primär angewendet werden. Die häufigsten vaskulären Komplikationen nach Nierentransplantation sind arterielle Stenosen (3 %–12,5 %), gefolgt von arteriellen und venösen Thrombosen (0,1 %–8,2 %) und Dissektionen (0,1 %). Seltener treten arteriovenöse Fisteln oder Pseudoaneurysmen auf. In diesen Fällen weist die minimalinvasive Therapie neben guten technischen und klinischen Ergebnissen auch eine niedrige Komplikationsrate auf. Die Diagnostik, Behandlung und Nachsorge sollten interdisziplinär an hochspezialisierten Zentren erfolgen, um einen Erhalt der Transplantatfunktion zu gewährleisten. Nur bei ausbleibendem Erfolg der minimalinvasiven Therapieverfahren sollte eine chirurgische Revision erwogen werden. Kernaussagen:  Zitierweise
    Type of Medium: Online Resource
    ISSN: 1438-9029 , 1438-9010
    URL: Article
    DOI: 10.1055/a-2007-9649
    RVK:
    XA 10000
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2023
    detail.hit.zdb_id: 2031079-1
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  • 8
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    Trajectories of glycaemic traits exhibit sex‐specific associations with hepatic iron and fat content: Results from the KORA‐MRI study
    Wiley ; 2023
    In:  Liver International Vol. 43, No. 10 ( 2023-10), p. 2153-2166
    Details
    In: Liver International, Wiley, Vol. 43, No. 10 ( 2023-10), p. 2153-2166
    Abstract: Non‐alcoholic fatty liver disease (NAFLD) represents a major disease burden in the population. While the bidirectional association between NAFLD and diabetes is established, little is known about the association of hepatic iron content and glycaemia. Moreover, analyses of sex‐specific effects and of dynamic changes in glycaemia are scarce. Methods We investigated 7‐year sex‐specific trajectories of glycaemia and related traits (HbA1c, fasting glucose, fasting insulin, HOMA‐IR, 2‐h glucose and cross‐sectional 2‐h insulin) in a sample from a population‐based cohort ( N  = 365; 41.1% female). Hepatic iron and fat content were assessed by 3T‐Magnetic Resonance Imaging (MRI). Two‐step multi‐level models adjusted for glucose‐lowering medication and confounders were applied. Results In women and men, markers of glucose metabolism correlated with hepatic iron and fat content. Deterioration of glycaemia was associated with increased hepatic iron content in men (normoglycaemia to prediabetes: beta = 2.21 s −1 , 95% CI [0.47, 3.95]). Additionally, deterioration of glycaemia (e.g. prediabetes to diabetes: 1.27 log(%), [0.84, 1.70] ) and trajectories of glucose, insulin and HOMA‐IR were significantly associated with hepatic fat content in men. Similarly, deterioration of glycaemia as well as trajectories of glucose, insulin and HOMA‐IR was significantly associated with increased hepatic fat content in women (e.g. trajectory of fasting insulin: 0.63 log(%), [0.36, 0.90]). Conclusions Unfavourable 7‐year trajectories of markers of glucose metabolism are associated with increased hepatic fat content, particularly in women, whereas the association with hepatic iron content was less clear. Monitoring changes of glycaemia in the sub‐diabetic range might enable early identification of hepatic iron overload and steatosis.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.v43.10
    DOI: 10.1111/liv.15635
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2124684-1
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  • 9
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    Serum insulin is associated with right ventricle function parameters and lung volumes in subjects free of cardiovascular disease
    Oxford University Press (OUP) ; 2021
    In:  European Journal of Endocrinology Vol. 184, No. 2 ( 2021-02), p. 289-298
    Details
    In: European Journal of Endocrinology, Oxford University Press (OUP), Vol. 184, No. 2 ( 2021-02), p. 289-298
    Abstract: Diabetes mellitus is an established risk factor for cardiovascular diseases. Even impaired levels of glucose and insulin might harm organ function prior to diabetes onset. Whether serum glucose or insulin plays a direct role in cardiac dysfunction or lung volume reduction remains unclear. The aim was to investigate the relationship between glucose and insulin with the right ventricle and lung volumes within KORA-MRI FF4 study. Methods From the KORA-MRI FF4 cohort study 337 subjects (mean age 55.7 ± 9.1 years; 43% women) underwent a whole-body 3T MRI scan. Cardiac parameters derived from a cine-steady-state free precession sequence using cvi42. MRI-based lung volumes derived semi-automatically using an in-house algorithm. Fasting serum glucose, fasting insulin levels, and HOMA index were calculated in all study subjects. Linear regression analyses were performed to assess the relationships between glucose and insulin levels with right ventricle volumes and lung volumes adjusted for age, sex, BMI, and cardiovascular risk factors. Results In univariate and multivariate-adjusted models, high serum insulin was inversely associated with end-diastolic volume (β = −12.43, P 〈 0.001), end-systolic volume (β = −7.12, P 〈 0.001), stroke volume (β = −5.32, P 〈 0.001), but not with ejection fraction. The association remained significant after additional adjustment for lung volumes. Similarly, serum insulin was inversely associated with lung volume (β = −0.15, P = 0.04). Sensitivity analysis confirmed results after excluding subjects with known diabetes. Conclusions Serum insulin was inversely associated with right ventricle function and lung volumes in subjects from the general population free of cardiovascular disease, suggesting that increased insulin levels may contribute to subclinical cardiopulmonary circulation impairment.
    Type of Medium: Online Resource
    ISSN: 0804-4643 , 1479-683X
    URL: Article
    DOI: 10.1530/EJE-20-1010
    RVK:
    WA 15000
    Language: Unknown
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1485160-X
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  • 10
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    Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a population-based cohort study
    Springer Science and Business Media LLC ; 2021
    In:  Scientific Reports Vol. 11, No. 1 ( 2021-08-09)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-08-09)
    Abstract: To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 subjects underwent whole-body MRI and spirometry as part of the KORA-FF4 cohort study. Lung volumes derived semi-automatically using an in-house algorithm. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and residual volume were measured. Cardiac parameters derived from Cine-SSFP-sequence using cvi42, while left ventricle (LV) time-volume-curves were evaluated using pyHeart. Linear regression analyses assessed the relationships of cardiac parameters with PFT and MRI-based lung volumes. Mean age was 56.3 ± 9.2 years (57% males). LV and right ventricular (RV) end-diastolic-, end-systolic-, stroke volume, LV peak ejection- and early/late diastolic filling rate were associated with FEV1, FVC, and residual volume (excluding late diastolic filling rate with FEV1, LV end-systolic/stroke volume and RV end-diastolic/end-systolic volumes with residual volume). In contrast, LV end-diastolic volume (ß = − 0.14, p = 0.01), early diastolic filling rate (ß = − 0.11, p = 0.04), and LV/RV stroke volume (ß = − 0.14, p = 0.01; ß = − 0.11, p = 0.01) were inversely associated with MRI-based lung volume. Subclinical cardiac impairment was associated with reduced FEV1, FVC, and residual volume. Cardiac parameters decreased with increasing MRI-based lung volume contrasting the results of PFT.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-021-95655-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
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