In:
Annals of Surgical Oncology, Springer Science and Business Media LLC, Vol. 27, No. 13 ( 2020-12), p. 5337-5346
Abstract:
Elderly patients with pancreatic cancer are underrepresented in clinical trials, resulting in a lack of evidence. Objective The aim of this study was to compare treatment and overall survival (OS) of patients aged ≥ 70 years with stage I–II pancreatic cancer in the EURECCA Pancreas Consortium. Methods This was an observational cohort study of the Belgian (BE), Dutch (NL), and Norwegian (NOR) cancer registries. The primary outcome was OS, while secondary outcomes were resection, 90-day mortality after resection, and (neo)adjuvant and palliative chemotherapy. Results In total, 3624 patients were included. Resection (BE: 50.2%; NL: 36.2%; NOR: 41.3%; p 〈 0.001), use of (neo)adjuvant chemotherapy (BE: 55.9%; NL: 41.9%; NOR: 13.8%; p 〈 0.001), palliative chemotherapy (BE: 39.5%; NL: 6.0%; NOR: 15.7%; p 〈 0.001), and 90-day mortality differed (BE: 11.7%; NL: 8.0%; NOR: 5.2%; p 〈 0.001). Furthermore, median OS in patients with (BE: 17.4; NL: 15.9; NOR: 25.4 months; p 〈 0.001) and without resection (BE: 7.0; NL: 3.9; NOR: 6.5 months; p 〈 0.001) also differed. Conclusions Differences were observed in treatment and OS in patients aged ≥ 70 years with stage I–II pancreatic cancer, between the population-based cancer registries. Future studies should focus on selection criteria for (non)surgical treatment in older patients so that clinicians can tailor treatment.
Type of Medium:
Online Resource
ISSN:
1068-9265
,
1534-4681
DOI:
10.1245/s10434-020-08539-x
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2020
detail.hit.zdb_id:
2074021-9
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