In:
Genetical Research, Hindawi Limited, Vol. 70, No. 3 ( 1997-12), p. 237-250
Abstract:
Linkage analysis and map construction using molecular
markers is far more complicated in full-sib families of outbreeding plant species than in progenies
derived from homozygous parents. Markers may vary in the number of segregating alleles. One or both
parents may be heterozygous, markers may be dominant or codominant and usually the linkage
phases of marker pairs are unknown. Because of these differences, marker pairs provide
different amounts of information for the estimation of recombination frequencies and the linkage
phases of the markers in the two parents, and usually these have to be estimated simultaneously.
In this paper we present a complete overview of all possible configurations of marker pairs
segregating in full-sib families. Maximum likelihood estimators for the recombination frequency and
LOD score formulas are presented for all cases. Statistical properties of the estimators are
studied analytically and by simulation. Specific problems of dominant markers, in particular with respect
to the probability of detecting linkage, the probability of obtaining zero estimates, and the
ability to distinguish linkage phase combinations, and consequences for mapping studies in
outbred progenies are discussed.
Type of Medium:
Online Resource
ISSN:
0016-6723
,
1469-5073
DOI:
10.1017/S0016672397003005
Language:
English
Publisher:
Hindawi Limited
Publication Date:
1997
detail.hit.zdb_id:
2412684-6
detail.hit.zdb_id:
1472156-9
SSG:
12
Permalink