In:
Diabetes, Obesity and Metabolism, Wiley, Vol. 17, No. 4 ( 2015-04), p. 395-402
Abstract:
To report baseline characteristics and cardiovascular ( CV ) risk management by region, age, sex and CV event type for 14 724 participants in the T rial E valuating C ardiovascular O utcomes with S itagliptin ( TECOS ), a randomized, double‐blind, placebo‐controlled trial exploring whether sitagliptin added to usual type 2 diabetes ( T2DM ) care affects time to first event in the composite endpoint of CV death, non‐fatal myocardial infarction ( MI ), non‐fatal stroke or unstable angina hospitalization. Methods TECOS enrolled patients aged ≥50 years, with T2DM and CV disease from 38 countries in five regions: N orth A merica, E astern E urope, W estern E urope, A sia P acific and L atin A merica. Participants had a glycated haemoglobin concentration of 6.5–8.0% (48–64 mmol/mol) and were receiving oral and/or insulin‐based antihyperglycaemic therapy. Analysis of variance or logistic regression was used to compare regional CV risk factors and treatments, referenced to N orth A merica. Results Patients had a mean [1 standard deviation (SD)] age of 66 (8) years, a median (interquartile range) diabetes duration of 9.4 (4.9, 15.3) years, and a mean (SD) body mass index 30.2 (5.7) kg/m 2 . Compared with N orth A merica, blood pressure and lipids were higher in all regions. Statin use was lowest in L atin A merica (68%) and E astern E urope (70%) and aspirin use was lower compared with N orth A merica in all regions except A sia P acific. Achievement of treatment targets did not differ by age group or insulin usage, but men and participants with previous MI were more likely than women or those with previous stroke or peripheral arterial disease to reach most treatment goals. Conclusion The CV risk factors of participants in TECOS are reasonably controlled, but differences in CV risk management according to region, sex and history of disease exist. This diversity will enhance the generalizability of the trial results.
Type of Medium:
Online Resource
ISSN:
1462-8902
,
1463-1326
DOI:
10.1111/dom.2015.17.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2004918-3
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