In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 7 ( 2021-7-9), p. e0254225-
Abstract:
Ayapana triplinervis is a plant species used in traditional medicine and in mystical-religious rituals by traditional communities in the Amazon. The aim of this study are to develop a nano-emulsion containing essential oil from A . triplinervis morphotypes, to evaluate larvicidal activity against Aedes aegypti and acute oral toxicity in Swiss albino mice ( Mus musculus ). The essential oils were extracted by steam dragging, identified by gas chromatography coupled to mass spectrometry, and nano-emulsions were prepared using the low energy method. Phytochemical analyses indicated the major compounds, expressed as area percentage, β-Caryophyllene (45.93%) and Thymohydroquinone Dimethyl Ether (32.93%) in morphotype A; and Thymohydroquinone Dimethyl Ether (84.53%) was found in morphotype B. Morphotype A essential oil nano-emulsion showed a particle size of 101.400 ± 0.971 nm (polydispersity index = 0.124 ± 0.009 and zeta potential = -19.300 ± 0.787 mV). Morphotype B essential oil nano-emulsion had a particle size of 104.567 ± 0.416 nm (polydispersity index = 0.168 ± 0.016 and zeta potential = -27.700 ± 1.307 mV). Histomorphological analyses showed the presence of inflammatory cells in the liver of animals treated with morphotype A essential oil nano-emulsion (MAEON) and morphotype B essential oil nano-emulsion (MBEON). Congestion and the presence of transudate with leukocyte infiltration in the lung of animals treated with MAEON were observed. The nano-emulsions containing essential oils of A . triplinervis morphotypes showed an effective nanobiotechnological product in the chemical control of A . aegypti larvae with minimal toxicological action for non-target mammals.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0254225
DOI:
10.1371/journal.pone.0254225.g001
DOI:
10.1371/journal.pone.0254225.g002
DOI:
10.1371/journal.pone.0254225.g003
DOI:
10.1371/journal.pone.0254225.g004
DOI:
10.1371/journal.pone.0254225.g005
DOI:
10.1371/journal.pone.0254225.t001
DOI:
10.1371/journal.pone.0254225.t002
DOI:
10.1371/journal.pone.0254225.t003
DOI:
10.1371/journal.pone.0254225.t004
DOI:
10.1371/journal.pone.0254225.t005
DOI:
10.1371/journal.pone.0254225.t006
DOI:
10.1371/journal.pone.0254225.t007
DOI:
10.1371/journal.pone.0254225.t008
DOI:
10.1371/journal.pone.0254225.s001
DOI:
10.1371/journal.pone.0254225.s002
DOI:
10.1371/journal.pone.0254225.s003
DOI:
10.1371/journal.pone.0254225.s004
DOI:
10.1371/journal.pone.0254225.s005
DOI:
10.1371/journal.pone.0254225.s006
DOI:
10.1371/journal.pone.0254225.s007
DOI:
10.1371/journal.pone.0254225.s008
DOI:
10.1371/journal.pone.0254225.s009
DOI:
10.1371/journal.pone.0254225.r001
DOI:
10.1371/journal.pone.0254225.r002
DOI:
10.1371/journal.pone.0254225.r003
DOI:
10.1371/journal.pone.0254225.r004
DOI:
10.1371/journal.pone.0254225.r005
DOI:
10.1371/journal.pone.0254225.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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