In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 2 ( 2023-2-6), p. e0281341-
Abstract:
Prognostic markers for fetal transmission of Cytomegalovirus (CMV) infection during pregnancy are poorly understood. Maternal CMV-specific T-cell responses may help prevent fetal transmission and thus, we set out to assess whether this may be the case in pregnant women who develop a primary CMV infection. Methods A multicenter prospective study was carried out at 8 hospitals in Spain, from January 2017 to April 2020. Blood samples were collected from pregnant women at the time the primary CMV infection was diagnosed to assess the T-cell response. Quantitative analysis of interferon producing specific CMV-CD8 + /CD4 + cells was performed by intracellular cytokine flow cytometry. Results In this study, 135 pregnant women with a suspected CMV infection were evaluated, 60 of whom had a primary CMV infection and samples available. Of these, 24 mothers transmitted the infection to the fetus and 36 did not. No association was found between the presence of specific CD4 or CD8 responses against CMV at the time maternal infection was diagnosed and the risk of fetal transmission. There was no transmission among women with an undetectable CMV viral load in blood at diagnosis. Conclusions In this cohort of pregnant women with a primary CMV infection, no association was found between the presence of a CMV T-cell response at the time of maternal infection and the risk of intrauterine transmission. A detectable CMV viral load in the maternal blood at diagnosis of the primary maternal infection may represent a relevant biomarker associated with fetal transmission.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0281341
DOI:
10.1371/journal.pone.0281341.g001
DOI:
10.1371/journal.pone.0281341.g002
DOI:
10.1371/journal.pone.0281341.g003
DOI:
10.1371/journal.pone.0281341.g004
DOI:
10.1371/journal.pone.0281341.g005
DOI:
10.1371/journal.pone.0281341.t001
DOI:
10.1371/journal.pone.0281341.t002
DOI:
10.1371/journal.pone.0281341.t003
DOI:
10.1371/journal.pone.0281341.s001
DOI:
10.1371/journal.pone.0281341.s002
DOI:
10.1371/journal.pone.0281341.s003
DOI:
10.1371/journal.pone.0281341.s004
DOI:
10.1371/journal.pone.0281341.s005
DOI:
10.1371/journal.pone.0281341.r001
DOI:
10.1371/journal.pone.0281341.r002
DOI:
10.1371/journal.pone.0281341.r003
DOI:
10.1371/journal.pone.0281341.r004
DOI:
10.1371/journal.pone.0281341.r005
DOI:
10.1371/journal.pone.0281341.r006
DOI:
10.1371/journal.pone.0281341.r007
DOI:
10.1371/journal.pone.0281341.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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