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  • 1
    Online Resource
    Online Resource
    Elsevier BV ; 2002
    In:  Brain Research Reviews Vol. 40, No. 1-3 ( 2002-10), p. 267-273
    In: Brain Research Reviews, Elsevier BV, Vol. 40, No. 1-3 ( 2002-10), p. 267-273
    Type of Medium: Online Resource
    ISSN: 0165-0173
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2002
    detail.hit.zdb_id: 1462685-8
    SSG: 12
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  • 2
    In: The Journal of Neuroscience, Society for Neuroscience, Vol. 31, No. 50 ( 2011-12-14), p. 18598-18605
    Abstract: After spinal cord transection, the generation of stepping depends on neurotransmitter systems entirely contained within the local lumbar spinal cord. Glutamate and glycine likely play important roles, but surprisingly little is known about how the content of these two key neurotransmitters changes to achieve weight-bearing stepping after spinal cord injury. We studied the levels of glutamate and glycine in the lumbar spinal cord of spinally transected rats. Rats ( n = 48) received spinal cord transection at 5 days of age, and 4 weeks later half were trained to step using a robotic treadmill system and the remaining half were untrained controls. Analyses of glutamate and glycine content via high-performance liquid chromatography showed training significantly raised the levels of both neurotransmitters in the lumbar spinal cord beyond normal. The levels of both neurotransmitters were significantly correlated with the ability to perform independent stepping during training. Glutamate and glycine levels were not significantly different between Untrained and Normal rats or between Trained and Untrained rats. There was a trend for higher expression of VGLUT1 and GLYT2 around motor neurons in Trained versus Untrained rats based on immunohistochemical analyses. Training improved the ability to generate stepping at a range of weight support levels, but normal stepping characteristics were not restored. These findings suggested that the remodeling of the lumbar spinal circuitry in Trained spinally transected rats involved adaptations in the glutamatergic and glycinergic neurotransmitter systems. These adaptations may contribute to the generation of novel gait patterns following complete spinal cord transection.
    Type of Medium: Online Resource
    ISSN: 0270-6474 , 1529-2401
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2011
    detail.hit.zdb_id: 1475274-8
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  • 3
    Online Resource
    Online Resource
    Society for Neuroscience ; 2007
    In:  The Journal of Neuroscience Vol. 27, No. 32 ( 2007-08-08), p. 8558-8562
    In: The Journal of Neuroscience, Society for Neuroscience, Vol. 27, No. 32 ( 2007-08-08), p. 8558-8562
    Abstract: The nervous system can adapt to external forces that perturb locomotion by correcting errors in limb movements. It is believed that supraspinal structures mediate these adaptations, whereas the spinal cord contributes only reflexive responses to perturbations. We examined whether the lumbar spinal cord in postnatal day 5 neonatal spinally transected (ST) rats corrected errors in hindlimb coordination through repetitive exposure to an external perturbation. A robotic device was used to deliver a viscous (velocity-dependent) force that opposed only the forward movement of the ankle in one hindlimb while the ST rats performed hindlimb stepping on a treadmill. We measured the interval between paw contact in the perturbed hindlimb and toe off in the unperturbed hindlimb. Before the force was activated, a normal pattern of coordination occurred: paw contact in the perturbed hindlimb occurred before toe off in the unperturbed hindlimb. This sequence was initially disrupted when the force was activated and the unperturbed hindlimb initiated swing during the swing phase of the perturbed hindlimb. Within five step cycles of exposure to the unilateral viscous force, however, the ST rats regained the preforce pattern of hindlimb coordination. These findings suggest that in the absence of supraspinal input, the lumbar spinal circuitry is capable of processing a complex ensemble of sensory information to maintain locomotor stability. Thus, the lumbar spinal circuitry may play a greater role in generating locomotor adaptations than previously thought.
    Type of Medium: Online Resource
    ISSN: 0270-6474 , 1529-2401
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2007
    detail.hit.zdb_id: 1475274-8
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  • 4
    In: The Journal of Physiology, Wiley, Vol. 533, No. 1 ( 2001-05), p. 15-22
    Abstract: The present review presents a series of concepts that may be useful in developing rehabilitative strategies to enhance recovery of posture and locomotion following spinal cord injury. First, the loss of supraspinal input results in a marked change in the functional efficacy of the remaining synapses and neurons of intraspinal and peripheral afferent (dorsal root ganglion) origin. Second, following a complete transection the lumbrosacral spinal cord can recover greater levels of motor performance if it has been exposed to the afferent and intraspinal activation patterns that are associated with standing and stepping. Third, the spinal cord can more readily reacquire the ability to stand and step following spinal cord transection with repetitive exposure to standing and stepping. Fourth, robotic assistive devices can be used to guide the kinematics of the limbs and thus expose the spinal cord to the new normal activity patterns associated with a particular motor task following spinal cord injury. In addition, such robotic assistive devices can provide immediate quantification of the limb kinematics. Fifth, the behavioural and physiological effects of spinal cord transection are reflected in adaptations in most, if not all, neurotransmitter systems in the lumbosacral spinal cord. Evidence is presented that both the GABAergic and glycinergic inhibitory systems are up‐regulated following complete spinal cord transection and that step training results in some aspects of these transmitter systems being down‐regulated towards control levels. These concepts and observations demonstrate that (a) the spinal cord can interpret complex afferent information and generate the appropriate motor task; and (b) motor ability can be defined to a large degree by training.
    Type of Medium: Online Resource
    ISSN: 0022-3751 , 1469-7793
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2001
    detail.hit.zdb_id: 1475290-6
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  • 5
    In: Neurorehabilitation and Neural Repair, SAGE Publications, Vol. 31, No. 8 ( 2017-08), p. 746-757
    Abstract: Background. The application of resistive forces has been used during body weight–supported treadmill training (BWSTT) to improve walking function after spinal cord injury (SCI). Whether this form of training actually augments the effects of BWSTT is not yet known. Objective. To determine if robotic-applied resistance augments the effects of BWSTT using a controlled experimental design in a rodent model of SCI. Methods. Spinally contused rats were treadmill trained using robotic resistance against horizontal (n = 9) or vertical (n = 8) hind limb movements. Hind limb stepping was tested before and after 6 weeks of training. Two control groups, one receiving standard training (ie, without resistance; n = 9) and one untrained (n = 8), were also tested. At the terminal experiment, the spinal cords were prepared for immunohistochemical analysis of synaptophysin. Results. Six weeks of training with horizontal resistance increased step length, whereas training with vertical resistance enhanced step height and movement velocity. None of these changes occurred in the group that received standard (ie, no resistance) training or in the untrained group. Only standard training increased the number of step cycles and shortened cycle period toward normal values. Synaptophysin expression in the ventral horn was highest in rats trained with horizontal resistance and in untrained rats and was positively correlated with step length. Conclusions. Adding robotic-applied resistance to BWSTT produced gains in locomotor function over BWSTT alone. The impact of resistive forces on spinal connections may depend on the nature of the resistive forces and the synaptic milieu that is present after SCI.
    Type of Medium: Online Resource
    ISSN: 1545-9683 , 1552-6844
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2100545-X
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  • 6
    Online Resource
    Online Resource
    Journal of Rehabilitation Research & Development ; 2013
    In:  Journal of Rehabilitation Research and Development Vol. 50, No. 6 ( 2013), p. 875-892
    In: Journal of Rehabilitation Research and Development, Journal of Rehabilitation Research & Development, Vol. 50, No. 6 ( 2013), p. 875-892
    Type of Medium: Online Resource
    ISSN: 0748-7711 , 1938-1352
    Language: English
    Publisher: Journal of Rehabilitation Research & Development
    Publication Date: 2013
    detail.hit.zdb_id: 2887606-4
    detail.hit.zdb_id: 2059450-1
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  • 7
    In: Journal of Neurotrauma, Mary Ann Liebert Inc, Vol. 23, No. 6 ( 2006-06), p. 882-896
    Type of Medium: Online Resource
    ISSN: 0897-7151 , 1557-9042
    Language: English
    Publisher: Mary Ann Liebert Inc
    Publication Date: 2006
    detail.hit.zdb_id: 2030888-7
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  • 8
    Online Resource
    Online Resource
    Elsevier BV ; 2015
    In:  Journal of Neuroscience Methods Vol. 246 ( 2015-05), p. 134-141
    In: Journal of Neuroscience Methods, Elsevier BV, Vol. 246 ( 2015-05), p. 134-141
    Type of Medium: Online Resource
    ISSN: 0165-0270
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2015
    detail.hit.zdb_id: 1500499-5
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  • 9
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2001
    In:  Physical Therapy Vol. 81, No. 12 ( 2001-12-01), p. 1904-1911
    In: Physical Therapy, Oxford University Press (OUP), Vol. 81, No. 12 ( 2001-12-01), p. 1904-1911
    Abstract: The recovery of stepping ability following a spinal cord injury may be achieved by restoring anatomical connectivity within the spinal cord. However, studies of locomotor recovery in animals with complete spinal cord transection suggest that the adult mammalian spinal cord can acquire the ability to generate stepping after all descending input is eliminated and in the absence of neuronal regeneration. Moreover, rehabilitative gait training has been shown to play a crucial role in teaching existing spinal pathways to generate locomotion and appropriately respond to sensory feedback. This brief review presents evidence that neural networks in the mammalian spinal cord can be modulated pharmacologically and/or with task-specific behavioral training to generate weight-bearing stepping after a spinal injury. Further, the role that spinal learning can play in the management of humans with spinal cord injury is discussed in relation to interventions that are designed primarily to enhance neuronal regeneration.
    Type of Medium: Online Resource
    ISSN: 0031-9023 , 1538-6724
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2001
    detail.hit.zdb_id: 2008745-7
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  • 10
    In: JMIR Rehabilitation and Assistive Technologies, JMIR Publications Inc., Vol. 8, No. 1 ( 2021-1-19), p. e16054-
    Abstract: Implementing exercises in the form of video games, otherwise known as exergaming, has gained recent attention as a way to combat health issues resulting from sedentary lifestyles. However, these exergaming apps have not been developed for exercises that can be performed in wheelchairs, and they tend to rely on whole-body movements. Objective This study aims to develop a mobile phone app that implements electromyography (EMG)-driven exergaming, to test the feasibility of using this app to enable people in wheelchairs to perform exergames independently and flexibly in their own home, and to assess the perceived usefulness and usability of this mobile health system. Methods We developed an Android mobile phone app (Workout on Wheels, WOW-Mobile) that senses upper limb muscle activity (EMG) from wireless body-worn sensors to drive 3 different video games that implement upper limb exercises designed for people in wheelchairs. Cloud server recordings of EMG enabled long-term monitoring and feedback as well as multiplayer gaming. Bench testing of data transmission and power consumption were tested. Pilot testing was conducted on 4 individuals with spinal cord injury. Each had a WOW-Mobile system at home for 8 weeks. We measured the minutes for which the app was used and the exergames were played, and we integrated EMG as a measure of energy expended. We also conducted a perceived usefulness and usability questionnaire. Results Bench test results revealed that the app meets performance specifications to enable real-time gaming, cloud storage of data, and live cloud server transmission for multiplayer gaming. The EMG sampling rate of 64 samples per second, in combination with zero-loss data communication with the cloud server within a 10-m range, provided seamless control over the app exergames and allowed for offline data analysis. Each participant successfully used the WOW-Mobile system at home for 8 weeks, using the app for an average of 146 (range 89-267) minutes per week with the system, actively exergaming for an average of 53% of that time (39%-59%). Energy expenditure, as measured by integrated EMG, was found to be directly proportional to the time spent on the app (Pearson correlation coefficient, r=0.57-0.86, depending on the game). Of the 4 participants, 2 did not exercise regularly before the study; these 2 participants increased from reportedly exercising close to 0 minutes per week to exergaming 58 and 158 minutes on average using the WOW-Mobile fitness system. The perceived usefulness of WOW-Mobile in motivating participants to exercise averaged 4.5 on a 5-point Likert scale and averaged 5 for the 3 participants with thoracic level injuries. The mean overall ease of use score was 4.25 out of 5. Conclusions Mobile app exergames driven by EMG have promising potential for encouraging and facilitating fitness for individuals in wheelchairs who have maintained arm and hand mobility.
    Type of Medium: Online Resource
    ISSN: 2369-2529
    Language: English
    Publisher: JMIR Publications Inc.
    Publication Date: 2021
    detail.hit.zdb_id: 2798120-4
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