In:
Letters in Drug Design & Discovery, Bentham Science Publishers Ltd., Vol. 16, No. 3 ( 2019-01-15), p. 364-369
Abstract:
Background: Antimicrobial resistance is a major threat to human health. So this manuscript
describes the synthesis of five different 3,5-disubstituted 4,5-dihydroisoxazoles with antimicrobial activity. 〈 /P 〉 〈 P 〉 Methods: They were obtained from nitrile oxide cycloaddition derived from 2-furaldehyde and 5-
nitro-2-furaldehyde to different dipolarophiles (acrylamide, ethyl acrylate and styrene). All heterocycles were isolated (30-50 %) and characterized by FTIR, MS, 1H and 13C NMR, as they were also
evaluated against Gram-positive and Gram-negative bacteria. 〈 /P 〉 〈 P 〉 Results and Conclusion: All products showed bioactivity against all bacteria, however, the heterocycle
3-(5-nitro-2-furanyl)-5-carboxylamide-4,5-dihydroisoxazole (6b) presented the lowest value for the minimum inhibition concentration (MIC - 14 & #181;g/mL).
Type of Medium:
Online Resource
ISSN:
1570-1808
DOI:
10.2174/1570180815666180627115606
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2019
SSG:
15,3
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